Electron Microscopy Laboratory (EML)

The EML offers investigators access to unique expertise and EM technologies that allow our partners to explore new avenues of research in order to enhance the knowledge of biological systems. To assist our customers, we provide complete specimen preparation service which includes shipment of fixative, processing, embedding, sectioning, and imaging of samples. If desired, investigators can also discuss the design of custom protocols tailored to their specific needs.

Core Capabilities

The EML provides Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) services as well as expertise in the following specialized areas: Immunoelectron microscopy, cryo-electron microscopy, negative stain analysis, ultrastructure analysis and virus particle characterization.

Instrumentation

The EM Lab suite includes four transmission electron microscopes and one scanning electron microscope. Supporting equipment includes an FEI Vitrobot, four ultramicrotomes, a high-resolution sputter coater and light microscopes with digital capture capability.

Established Technologies

  • transmission electron microscopy (TEM)
  • scanning electron microscopy (SEM)
  • cryo-electron microscopy
  • electron tomography
  • nanoparticle analysis (soft matter and hard matter)
  • elemental analysis by energy dispersive x-ray spectroscopy
  • selected area electron diffraction
  • consultation/training
  • image data storage and access

OSTR provides subsidies for high-risk projects from the Electron Microscopy Lab.

Contact Details:
Natalia De Val Alda, Ph.D.
301.846.5384
 devalaldan2@mail.nih.gov

Kunio Nagashima
301.846.1594
 nagashimak@mail.nih.gov