The NIH Metabolomics Consortium (NIH-MC) is a shared research resource that performs metabolomics analysis (and related small molecule research) for investigators at all Institutes and Centers across the NIH Intramural Research Program. The NIH-MC is administered at NIEHS with participating laboratories at NIEHS, NIA, and NIAID. The NIH-MC was established in 2023, by the SRS Subcommittee of the Scientific Directors, and continues to grow in the offerings provided, expertise, and participatory labs.
Established Technologies
Metabolomics measures the small molecules – endogenous and exogenous – that underpin biological changes in response to diet, behavior, exposure, disease, and more.
Currently, the NIH-MC offers two general types of metabolomics approaches – targeted and untargeted – covering different aspects of metabolism and to varying degrees of analytical measurement. Each offering has unique requirements, deliverables, and costs – please review the information for each offering carefully. The specific metabolomics assays offered, by site, are:
National Institute on Aging (NIA)
National Institute of Allergy and Infectious Disease (NIAID)
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Bile Acids
– Quantification of primary and secondary bile acids, including conjugated and free forms.
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Short Chain Fatty Acids
– Quantification of short-chain fatty acids (consult prior to sample collection).
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Targeted Lipidomics
– Relative quantitation of a broad panel of >1700 individual glycerolipid, sphingolipid, and sterol lipids.
- Oxidized immune lipid mediators
National Institute of Environmental Health Sciences (NIEHS)
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Untargeted Metabolomics
– Measurement of the relative changes of all detectable chemicals/metabolites in a specimen as part of a
global metabolic profile.
- Glutathione and metabolites panel (Gamma-glutamylcysteine, glutathione, and glutathione disulfide)
- Chlorpyrifos and metabolites panel (Chlorpyifos, Chlorpyrifos-oxon, and 3,5,6-trichloro-2-pyridinol)
- *coming soon* Mass Spectrometry Imaging for Spatial Lipidomics or Metabolomics
Pricing
Cost varies across assays but is highly competitive with academic laboratories and commercial services. Cost will be discussed and agreed
upon prior to starting the project. Different NIH Institutes/Centers handle Investigator costs for core facilities using different mechanisms, so we recommend that you inquire with your Lab/Branch Chief or
Scientific Director.