Established and emerging technologies are needed by CCR investigators in order to systematically dissect the heterogeneity of cancer in order to gain a better understanding of the causes of invasion, metastasis, and therapy resistance. These coveted technologies have been identified as having the strongest footing among the leading institutions around the world that are focused on Single Cell (SC) genomic analysis. The OSTR is dedicated to providing these groundbreaking technologies to CCR investigators through educational and informational resources designed to introduce users to various scientific methodologies, as well as seminars on current advancements in scientific methods and instrumentation.

OSTR Technology Seminars

Adaptive ImmunoSeq TCR Sequencing

Adaptive ImmunoSeq TCR Sequencing specifically as it relates to accelerating discovery and innovation.

Emerging Assays on 10X Platforms

Biology at True Resolution: Resolving biology with single cell genomics, multi-omics, and spatial transcriptomes.

Single RNA Molecule Detection with RNAscope

Detecting single RNA molecule at single cell resolution in intact tissue, with unique applications in gene therapy, cell therapy, point mutation, and sc RNAseq validation.

Core Services: Mass Spectrometry

NIH ORS and NIH Collaborative Research Exchange (CREx) Panel Discussion Series. Panel 1. October 27, 2021

Livecyte: Kinetic Cytometry

A new chapter in the evolution of live single cell analysis for cancer research

Center for Advanced Tissue Imaging (CAT-I)

This seminar will detail IBEX, RAPID, Ce3D, and other technologies, show examples of their application to various tissues and cancers, and explain how CAT-I is structured to enable access to these methods by CCR investigators

An Overview of CREx

Learn how to easily search research services, identify appropriate service providers and NIH Core Facilities, and submit and manage research service requests for all your research needs.

Animal Research Services

NIH ORS and NIH CREx Panel Discussion Series. Panel 2: Animal Model Research Services. February 24, 2022.

Core Spotlight Seminar

Christopher Bleck, Ph.D., Director, NHLBI Electron Microscopy Core

“Biology Goes 3D: Volume Electron Microscopy of Biological Specimens”

Core Spotlight Seminar

Dillon Chung, Ph.D., NHLBI Laboratory of Cardiac Energetics at NHLBI

“Mitochondrial Network Formation as a Tissue-Specific Phenomenon in a Mammalian Model of Extreme Metabolism

Core Spotlight Seminar

Raymond Fields, Director, NINDS Viral Production Core

“An Introduction to Viral Vectors and the NINDS Viral Production Core Facility”

Core Spotlight Seminar

Emily Petrus, Ph.D., NINDS Laboratory of Functional and Molecular Imaging

“Viral Enabled Study of the Neurons and Circuits Underlying the Brain’s Response to Peripheral Injury”

OSTR Technology Educational Video Series

Protein Mass Spectrometry

Structural Mass Spectrometry related to crosslinking and limited proteolysis mass spectrometry approaches.

Quantitative mass spectrometry, specifically the global discovery experiments in mass spectrometry.

PTM mass spectrometry, specifically the analysis of post-translational modifications by mass spectrometry.

Interactome mass spectrometry approaches specifically, proximity-dependent biotinylation for mapping protein complexes mass spectrometry.

Structural mass spectrometry approaches specifically, Hydrogen/Deuterium Exchange mass spectrometry.

Molecular Microscopy

An introduction to focused ion beam scanning electron microscopy (FIB-SEM) as it relates to visualizing cells in 3-D and at the nanoscale level.