Established and emerging technologies are needed by CCR investigators in order to systematically dissect the heterogeneity of cancer in order to gain a better understanding of the causes of invasion, metastasis, and therapy resistance. These coveted technologies have been identified as having the strongest footing among the leading institutions around the world that are focused on Single Cell (SC) genomic analysis. The OSTR is dedicated to providing these groundbreaking technologies to CCR investigators through educational and informational resources designed to introduce users to various scientific methodologies, as well as seminars on current advancements in scientific methods and instrumentation.

OSTR Technology Seminars

Adaptive ImmunoSeq TCR Sequencing

Adaptive ImmunoSeq TCR Sequencing specifically as it relates to accelerating discovery and innovation.

Emerging Assays on 10X Platforms

Biology at True Resolution: Resolving biology with single cell genomics, multi-omics, and spatial transcriptomes.

Single RNA Molecule Detection with RNAscope

Detecting single RNA molecule at single cell resolution in intact tissue, with unique applications in gene therapy, cell therapy, point mutation, and sc RNAseq validation.

Core Services: Mass Spectrometry

NIH ORS and NIH Collaborative Research Exchange (CREx) Panel Discussion Series. Panel 1. October 27, 2021

Livecyte: Kinetic Cytometry

A new chapter in the evolution of live single cell analysis for cancer research

OSTR Technology Educational Video Series

Protein Mass Spectrometry

Structural Mass Spectrometry related to crosslinking and limited proteolysis mass spectrometry approaches.

Quantitative mass spectrometry, specifically the global discovery experiments in mass spectrometry.

PTM mass spectrometry, specifically the analysis of post-translational modifications by mass spectrometry.

Interactome mass spectrometry approaches specifically, proximity-dependent biotinylation for mapping protein complexes mass spectrometry.

Structural mass spectrometry approaches specifically, Hydrogen/Deuterium Exchange mass spectrometry.

Molecular Microscopy

An introduction to focused ion beam scanning electron microscopy (FIB-SEM) as it relates to visualizing cells in 3-D and at the nanoscale level.