Centralized research resource facilities that provide access to advanced instrumentation, cutting-edge technologies, and expert consultation. Cores provide opportunities to be hubs of innovation and connect scientists with tools and expertise that can advance their research to the next level.
A multi-disciplinary and multi-institutional network of resources whose collective efforts can enable transformational advances in the most promising research areas. The program is designed to foster scientific breakthroughs by providing resources not usually available to individual investigators, or small groups.
The Collaborative Research Exchange (CREx) is an online NIH marketplace for investigators to search, browse, and request information for research services, technologies, or products offered by NCI/NIH Cores, Collaborative Resources, and commercial vendors.
Weds. Nov. 14, 2018, 9 AM – 11 AM, as part of BTEP’s “Variant Analysis in WGS and WES” mini-series, BTEP presents Dr. Justin Lack, Bioinformatics Manager/ Lead, NIAID Collaborative Bioinformatics Resource (NCBR) Ft. Detrick, Read more…
Variant Analysis using Genomatix GeneGrid Susan M. Dombrowski, PhD and Peter Grant, Genomatix, Inc. *Please bring a laptop with Flash installed for the hands-on portion of this demo. **This class will be held in NIH Read more…
10x Genomics: Whole Exome and Whole Genome Analysis How 10x Genomics linked reads works SNVs, copy number variations, structural variants and phasing of the variants from linked read data Walk through of 10x Genomics WGS Read more…
We provide evidence that hepatic CSCs at the single-cell level are phenotypically, functionally, and transcriptomically heterogeneous. We found that different CSC subpopulations contain distinct molecular signatures.
Overall, our studies highlight dCas9-p300 as a powerful tool for studying gene expression mechanisms in which acetylation plays a causal role and provide a foundation for future applications requiring spatiotemporal control over acetylation at specific genomic loci.
Active peptides were shown to have inhibitory effects on cell viability, reduced NF-κB activity and decreased production of NF-κB related gene products. This work further demonstrates the potential of LUBAC as a therapeutic target and of the use of stapled peptides as inhibitors of protein-protein interactions.
