Centralized research resource facilities that provide access to advanced instrumentation, cutting-edge technologies, and expert consultation. Cores provide opportunities to be hubs of innovation and connect scientists with tools and expertise that can advance their research to the next level.
A multi-disciplinary and multi-institutional network of resources whose collective efforts can enable transformational advances in the most promising research areas. The program is designed to foster scientific breakthroughs by providing resources not usually available to individual investigators, or small groups.
The Collaborative Research Exchange (CREx) is an online NIH marketplace for investigators to search, browse, and request information for research services, technologies, or products offered by NCI/NIH Cores, Collaborative Resources, and commercial vendors.
Special exhibits on resources will be available for intramural research. The NIAID OCICB Bioinformatics and Computational Biosciences Branch (BCBB) will have an exhibit. The NIAID OCICB serves the NIAID research community and inter-institute collaborators providing Read more…
Joint Annual Investigators Meeting for the NCI Cancer Systems Biology Consortium and Physical Sciences-Oncology Network Date: September 25-28, 2018 Location: Ruth Kirschstein Auditorium, Natcher Conference Center Register to attend by August 30: csbcpson2018.org
Highly Multiplexed, Spatially-Resolve Tissue Analysis using the CODEX System Dr. Garry Nolan of Stanford University will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a Read more…
“Gene editing of primary human cells using Scalable Transfection Systems ” Please join us in welcoming MaxCyte, Inc. to NHLBI to present their technology for high quality and efficient gene editing of primary human cells. MaxCyte, Inc. Read more…
We provide evidence that hepatic CSCs at the single-cell level are phenotypically, functionally, and transcriptomically heterogeneous. We found that different CSC subpopulations contain distinct molecular signatures.
Overall, our studies highlight dCas9-p300 as a powerful tool for studying gene expression mechanisms in which acetylation plays a causal role and provide a foundation for future applications requiring spatiotemporal control over acetylation at specific genomic loci.
Active peptides were shown to have inhibitory effects on cell viability, reduced NF-κB activity and decreased production of NF-κB related gene products. This work further demonstrates the potential of LUBAC as a therapeutic target and of the use of stapled peptides as inhibitors of protein-protein interactions.
