NCI-CCR Resource Categories

CCR Cores and collaborative resources make services and expertise available to CCR investigators. Technologies and expertise offered through collaborative resources (CCR Research Labs and Lab/Branch Facilities) are at the discretion of the Principal Investigator or Lab/Branch Chief.
Cores

Cores

Centralized research resource facilities that provide access to advanced instrumentation, cutting-edge technologies, and expert consultation. Cores provide opportunities to be hubs of innovation and connect scientists with tools and expertise that can advance their research to the next level.

Collaborative

Collaborative

A multi-disciplinary and multi-institutional network of resources whose collective efforts can enable transformational advances in the most promising research areas. The program is designed to foster scientific breakthroughs by providing resources not usually available to individual investigators, or small groups.

CREx

CREx

The Collaborative Research Exchange (CREx) is an online NIH marketplace for investigators to search, browse, and request information for research services, technologies, or products offered by NCI/NIH Cores, Collaborative Resources, and commercial vendors.


Our Mission

The Office of Science and Technology Resources (OSTR) catalyzes the advancement of cancer research through making innovative technologies and scientific resources accessible to scientists at the Center for Cancer Research (CCR). OSTR develops partnerships, collaborations, and agreements with outside organizations with the primary goal of furthering the scientific mission of the CCR.

Supplemental Technology Award Review System (STARS)

Technology and Bioinformatics Events

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CCR Publications Supported by OSTR

The OSTR provides technology advice and funding to support ongoing CCR research
Single cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

Single cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

Zheng H, et al.

We provide evidence that hepatic CSCs at the single-cell level are phenotypically, functionally, and transcriptomically heterogeneous. We found that different CSC subpopulations contain distinct molecular signatures.

Chemical Control of a CRISPR-Cas9 Acetyltransferase

Chemical Control of a CRISPR-Cas9 Acetyltransferase

Shrimp JH, et al.

Overall, our studies highlight dCas9-p300 as a powerful tool for studying gene expression mechanisms in which acetylation plays a causal role and provide a foundation for future applications requiring spatiotemporal control over acetylation at specific genomic loci.

Biophysical and biological evaluation of optimized stapled peptide inhibitors of the linear ubiquitin chain assembly complex (LUBAC).

Biophysical and biological evaluation of optimized stapled peptide inhibitors of the linear ubiquitin chain assembly complex (LUBAC).

Christophe Cataisson, et al.

Active peptides were shown to have inhibitory effects on cell viability, reduced NF-κB activity and decreased production of NF-κB related gene products. This work further demonstrates the potential of LUBAC as a therapeutic target and of the use of stapled peptides as inhibitors of protein-protein interactions.