Spatial Biology

GeoMx® Digital Spatial Profiler

• Discover biomarkers predictive of therapeutic response.
• Profile the tumor microenvironment.
• Uncover drug mechanism of action.
• Reveal molecular subtypes for diseases.

PhenoCycler

• Image 1 million cells in 10 minutes with accelerated parallel imaging and fluidics.
• Effortlessly phenotype 40 samples at 20-plex or 300 samples at 6-plex.
• Unlock scalable plexing with our barcoded antibody technology.

Nanostring CosMx Spatial Molecular Imager

• High-plex in situ spatial multiomic analysis of FFPE and fresh frozen samples at cellular and sub-cellular resolution.
• Analyze of up to 1,000 genes and 64 proteins on one slide.
• Spatially analyze up to 6,000 genes per FFPE slide.
• Identify up to 68 proteins per FFPE slide.

10x Genomics Xenium Analyzer

• Simultaneous expression analysis of RNA targets within the same FFPE or fresh frozen tissue section (currently 500 genes).
• Generate a single cell resolution map of expression patterns of all genes in panel.
• Ability to add up to 100-genes or design a full custom panel.
• Future panels are promised at 1000 or 5000-plex and include simultaneous profiling of proteins.

Visium Spatial Gene Expression

• Whole transcriptome survey of the gene expression profiles across mouse or human FFPE or fresh frozen tissue section.
• Tissue samples on normal glass slides used as input (CytAssist used to transfer tissue to Visium spatially barcoded slides).
• Arrayed spatial spots provide unbiased profile of tissue (no ROI selection necessary).
• Analyze the whole transcriptome from an entire tissue section.

Center for Advanced Tissue Imaging (CAT-I)

• To enable investigators to collaborate with experts in the Laboratory of Immune System Biology.
• To enable quantitative image analysis of tissue samples, primarily but not exclusively of human origin.
• To use these data to advance our understanding of immune processes in various diseases.