The rapid advancement of single-cell technology has provided new powerful tools to answer many biological questions, such as identifying new or rare cell populations and characterizing the complexities of tumor heterogeneity.  Realizing the great potential of single-cell technology in cancer research, the CCR has established the Single Cell Analysis Facility (SCAF) located on the Bethesda main campus.The SCAF works closely with CCR Sequencing Facility to also extend support to CCR Investigators located in Frederick, and works with other associated support groups at CCR, including CCR Genomic… [learn more]

The Nanoscale Protein Analysis Section of the CCR Collaborative Protein Technology Resource (CPTR) provides expertise and service in state-of-the-art protein analysis technologies to advance CCR research in basic discovery and translation/clinical studies. Applications include: Quantitative profiling of cell signaling and post-translational modification Measurement of cytokine, metabolite and serum/plasma markers Identification and validation of biomarkers & therapeutic targets Assessment of on‐ and off‐target drug activity and pharmacodynamic evaluation Study of tumor microenviron… [learn more]

The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at previously unthinkable speeds and a fraction of their former cost. At the Sequencing Facility, researchers are provided access to the latest technologies, with consultation and Q&A services available throughout the design and execution of sequencing projects. SF is a CCR-dedicated facility open to all CCR Investigators. Dedicated capacity has also been established for … [learn more]