NCI LASP Animal Research Technology Support (ARTS) provides customized technical support for basic and translational animal-based research to the scientific community. We offer a wide array of services ranging from expert colony management to the performance and development of technical procedures aimed at the disease induction, characterization, and treatment of animal models.
Technologies
- Development and implementation of specialized technical procedures for induction and characterization of tumorigenesis in preclinical animal models
- Assessment of PK/PD and efficacy of investigational compounds and anticancer therapeutics
- Assessment of genetic, immunologic and metabolic function during disease progression
- Colony management for rodent line maintenance, expansion and cohort production
- Characterization of animal models throughout all stages of development
- Genetic, viral, or chemical induction of tumorigenesis in mouse models allograft, xenograft, patient-derived xenografts, genetically engineered mouse models
- Procedures aimed at assessment of immune functions such as bone marrow transplantations, adoptive cell transfers, immunizations
- Collection of body fluids and tissues including perfusion and sample preservation
- Calculation, formulation, and administration of medicated water, diets or chemicals
- Administration routes: IP, ID, SC, IV, IG, IM, intra-renal, intra-nasal, intra-tracheal, intra-rectal, intra-cardiac, intra-cranial, intra-splenic, intra-hepatic, mammary fat pad, topical skin-painting
- Surgical procedures such as tumor implants, tumor excision, splenectomy, partial hepatectomy, implantations of osmotic pumps and slow-release devices
- Development and implementation of new Standard Operating Procedures and assistance with experimental study design to address customer needs