Animal Resources

The CCR Animal Resource Program (ARP) plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. Coordinates the use of animal holding spaces within the NCI animal facilities, NIH central animal facilities, and shared animal facilities., Oversees the use of all centrally funded animal resources., Assists with cost-effective options for animal technical support, off-site animal contracts., Coordinates/negotiates animal-related interagency ag… [learn more]

The Animal Diagnostic Laboratory (ADL) provides a full range of diagnostic capabilities, including microbiological cultures on various culture medium, microscopic screening for parasites such as mites and pinworms, molecular detection of pathogens, serological evaluation of antibodies, and necropsy. The High-Throughput Animal Genotyping Lab (HTAGL) within ADL utilizes robotic liquid handling systems to assist in the genotyping of mice using quantitative PCR or end-point PCR analysis. Technologies: Molecular Testing of Biological Materials (MTBM), Molecular diagnostic for murine pat… [learn more]

NCI LASP Animal Research Technology Support (ARTS) provides customized technical support for basic and translational animal-based research to the scientific community. We offer a wide array of services ranging from expert colony management to the performance and development of technical procedures aimed at the disease induction, characterization, and treatment of animal models. Technologies: Development and implementation of specialized technical procedures for induction and characterization of tumorigenesis in preclinical animal models, Assessment of PK/PD and efficacy of investig… [learn more]

The Laboratory Animal Sciences Program (LASP) of the Frederick National Laboratory operates a Gnotobiotics Facility (GF) to support research focused on the role of microbiota in cancer inflammation, pathogenesis, and treatment response. The GF can rederive mice into germ-free status, expand colonies of axenic and gnotobiotic mice, and maintain microbiome-defined lines of animals. The team also has extensive experience working with animal models in basic and translational research, particularly in the fields of immunology and cancer. The GF works closely with Investigators throughout all sta… [learn more]

The Mouse Modeling Core assists NIH investigators by generating and preserving genetically-engineered mouse strains. Services include scientific consultation, gene-targeting in mouse embryonic stem cells, micro-injection of nucleic acids, proteins, or ES cells into mouse embryos, in vitro fertilization, cryopreservation of germplasm, and regeneration of mice from frozen stocks. The MMC also interfaces with the Genome Modification Core to generate genetically or epigenetically-altered lines of mice using CRISPR and other nuclease-based methods (TALENS, Zn Fingers). The NCI Mouse Repo… [learn more]

The function of the SAIP is to collaborate with NCI investigators in the development of mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies utilizing in vivo imaging techniques. In addition, the SAIP collaborates with the NCI Division of Cancer Treatment and Diagnosis (DCTD) Nanotechnology Characterization Laboratory (NCL) to analyze nanoplatforms as part of the cascade assay and assist DCTD initiatives in developing standards in small animal imaging, integrate imaging into drug development, and develop par… [learn more]

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes. Established Technologies: Cardiovascular Phenotyping, Metabolic Phenotyping, Pulmonary Phenotyping, Behavioral Phenotyping, Exercise Physiology, Echocardiography, In vivo functional vascular phenotyping, Advanced Imaging Modalities (whole body high frequency ultrasound imaging, vascular imaging), [learn more]

The FNLCR Molecular Histopathology Laboratory (MHL) provides comprehensive veterinary pathology support for animal health monitoring, biomarker discovery and validation, drug development, genomics, and proteomics on a cost recovered basis. The MHL is organized into multiple process groups with cross-trained experts in animal study design, phenotyping of genetically engineered mice (GEM), immunopathology, anatomic pathology, toxicological pathology, and specimen classification/selection for tissue microarray (TMA) construction or laser capture microdissection (LCM). Established… [learn more]