NIA Nonhuman Primate Core

Overview

The NIA Nonhuman Primate (NHP) Core Facility maintains a large colony of aging rhesus macaques at the National Institutes of Health Animal Center. The Core program was established in 2012 to support the experimental goals of intramural investigators and extramural collaborators. For over 30 years the NIA IRP has been conducting a longitudinal study of calorie restriction in rhesus monkeys. As a result, we have extensive experience collecting a wide range of nonhuman primate physiological and behavioral data. Rhesus monkeys have an average lifespan of 27 years in captivity and can live to be 40 years of age. We have 100+ male and female rhesus monkeys from 3-30 years old available for short-term intervention studies and experiments to evaluate putative biomarkers of aging. We also have an extensive tissue bank readily available for requests.

Established Technologies

• Imaging Services
  • Ultrasound, echocardiogram (2D & 3D imaging), Doppler, EKG, Digital Radiography, Dual-Energy X-Ray Absorptiometry (DEXA)
• Piccolo Xpress Chemistry
• Nutritional Data Collection
• Glucose Tolerance Testing
• Pharmacodynamics/Pharmacokinetics
  • Intervention Studies (e.g., Dietary, Drug, Exercise)
  • Identifying Novel Models of Human Disease
  • Proof of Concept

Note: We are not limited to these types of studies and welcome opportunities to grow our program.

Publications

• Walker EM, et al. Dysregulation of IL-17/IL-22 effector functions in blood and gut mucosal Gamma Delta T cells correlates with increase in circulating leaky gut and inflammatory markers during cART-treated chronic SIV infection in macaques. Front Immunol. 2021 Feb 25; doi.org/10.3389/fimmu.2021.647398.
• Stonebarger GA, et al. Amyloidosis increase is not attenuated by long-term calorie restriction or related to neuron density in the prefrontal cortex of extremely aged rhesus macaques. Geroscience. 2020 Dec; 42:1733-1749. doi: 10.1007/s11357-020-00259-0..
• Yen K, et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging. 2020 Jun 23;12:11185-11199. doi: 10.18632/aging.103534.
• Hu Q, et al. Increased drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction. Circ Res. 2020 Feb 14;126:456-470. doi: 10.1161/circresaha.119.315252.
• Aon MA, et al. Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice. Cell Metab. 2020 Jul 7;32:100-116.e104. doi: 10.1016/j.cmet.2020.04.018.
• Tosh DK, et al. Design and in vivo characterization of a(1) adenosine receptor agonists in the native ribose and conformationally constrained (n)-methanocarba series. J Med Chem. 2019 Feb 14;62:1502-1522. doi: 10.1021/acs.jmedchem.8b01662.
• Li Y, et al. Pharmacokinetics of exenatide in nonhuman primates following its administration in the form of sustained-release pt320 and bydureon. Sci Rep. 2019 Nov 20;9:17208. doi: 10.1038/s41598-019-53356-2.
• Khayrullin A, et al. Very long-chain c24:1 ceramide is increased in serum extracellular vesicles with aging and can induce senescence in bone-derived mesenchymal stem cells. Cells. 2019 Jan 10;8. doi: 10.3390/cells8010037.
• Demarest TG, et al. Assessment of nad(+)metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle. Anal Biochem. 2019 May 1;572:1-8. doi: 10.1016/j.ab.2019.02.019.
• Bodogai M, et al. Commensal bacteria contribute to insulin resistance in aging by activating innate b1a cells. Sci Transl Med. 2018 Nov 14;10. doi: 10.1126/scitranslmed.aat4271.
• Abdelmohsen K, et al. Circular rnas in monkey muscle: Age-dependent changes. Aging. 2015 Nov;7:903-910. doi: 10.18632/aging.100834.