The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization and utilization of models of human disease. The initiative approach includes both applied research and collaborations aimed at developing new reagents, methods, and technologies in preclinical diagnostic medicine; thus enhancing capabilities to integrate molecular and systemic aspects of disease mechanisms. Designing and employing state of the art medical and pathology investigative tools to the study of animal m… [learn more]

The NIA Nonhuman Primate (NHP) Core Facility maintains a large colony of aging rhesus macaques at the National Institutes of Health Animal Center. The Core program was established in 2012 to support the experimental goals of intramural investigators and extramural collaborators. For over 30 years the NIA IRP has been conducting a longitudinal study of calorie restriction in rhesus monkeys. As a result, we have extensive experience collecting a wide range of nonhuman primate physiological and behavioral data. Rhesus monkeys have an average lifespan of 27 years in captivity and can live to be … [learn more]

The core's goal is to help researchers of any expertise perform zebrafish experiments aimed at illuminating basic biology and human disease mechanisms, thereby advancing the NIH and NICHD 's research missions.  A typical research question might investigate the function or regulation of a zebrafish gene and/or its ortholog from humans or another species. We are also happy to offer consultation for any other zebrafish-related projects you may be considering. The core is equipped to assist with the following methodologies:Gene expression and regulation studiesIn situ hybridization to charact… [learn more]

The Division of Veterinary Resources’ (DVR) mission is to contribute to the advancement of NIH biomedical research programs by providing excellence in animal care, customer service, and specialized research services to support intramural research efforts. DVR’s diverse and dedicated staff emphasizes accountability to the NIH researcher’s needs in areas including humane animal and veterinary care, animal behavior and enrichment, diagnostics and health surveillance, surgery, pharmacy, procurement, nutrition, and animal transportation.Established TechnologiesDVR professional staff is … [learn more]

The Division of Veterinary Resources Animal Surgery has supported large animal research and clinical care for more than 40 years. DVR surgeons provide outstanding and highly specialized large animal (rabbits, ungulates, etc.) research support in a state of the art surgical suite. Specialty support includes surgical expertise, surgical and technical support, animal model development, and investigator training. We seek to support the unique needs and requirements of each investigator using animals in either basic or translational research.Established TechnologiesFacilities and EquipmentState… [learn more]

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, mortality or unexpected findings. In addition, mouse phenotyping and transmission electron microscopy services are available. Established Technologies The Pathology Service offers a Mouse Phenotyping Service with comprehensive pathologic analysis for genetically engineered mice. The Service provides standardized gross and histopathologic … [learn more]