NATIONAL CANCER INSTITUTE - CANCER.GOV

Contact Information


Primary Contact

Kent Lloyd, DVM, PhD
Principal Investigator

Location

1 sheilds avenue
University of California Davis
Davis, CA 95616

Overview

The Mouse Metabolic Phenotyping Center (MMPC)Live Program provides standardized, high quality, unique, and hard to find phenotyping services for mouse models of diabetes, obesity, and related metabolic disorders. Emerging as the next iteration of the MMPC Program (2001–2021), MMPCLive is an outwardly-facing consortium of service cores that offer investigators reduced-cost consultation and metabolic, physiologic, and behavioral phenotyping tests on live mice. Four MMPCLive Centers located at universities around the country perform complex and often unique procedures in vivo on a fee-for-service basis, typically on mice shipped from the client or directly from a repository or vendor. The Centers provide consultation, training, and services in the area of energy balance and body composition, insulin action and secretion, whole body carbohydrate and lipid metabolism, cardiovascular and renal function, food intake and behavior, microbiome and xenometabolism, and metabolic pathway kinetics in live mice. Data derived from experiments conducted at an MMPCLive Center belongs to the researchers submitting mice for testing and is made publicly available and accessible from the MMPCLive database following publication. The MMPCLive Centers apply broad-based strategies to optimize rigor, reproducibility, and translatability of biomedical research using mouse models. In addition to services, Centers staffs provide expertise and advice to researchers, develop and refine test protocols, engage in outreach activities, publish scientific and technical papers, and conduct educational workshops and training sessions to aid researchers in unraveling the heterogeneity of diabetes and obesity.

Major Instrumentation

Promethion System (Sable) with continuous body temperature monitoring system, Intelligent Optogenetics System and Multichannel Fiber Photometry System, Kope Stereotaxic Alignment System, Automated In Vivo Sampling System

Publications

  • Laughlin M, McIndoe R, Adams SH, et al. The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mamm Genome 2024;35:485u2013496. https://doi.org/10.1007/s00335-024-10067-y.
  • Walker EM, Pearson GL, Lawlor N, et al. Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues. Science 2025;388(6743):eadf2034. https://www.science.org/doi/10.1126/science.adf2034.

Keywords

MMPCMouse Metabolic Phenotyping CenterMouse Metabolic Phenotyping CentersNIHNIH Mouse Metabolic Phenotyping Centers (MMPC)LiveUniversity of California DavisUniversity of MichiganVanderbilt UniversityYale Universitydiabetesin vivoinbredmetabolic.metabolismmicemodelmouseobesityphenotypephenotypingtesting