Contact Information

Primary Contact

Sergey Tarasov
Facility Head


538 Chandler Street
Frederick, MD 21702

Additional Contacts

Marzena A. Dyba, MS
Research Assistant


The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The BR operates as an open, shared-use facility; in general, BR users learn to operate the instruments and conduct their own experiments. Biophysics Resource staff members train all first-time users and are also available to consult with investigators on experimental design/analysis or collaborate with them on more complex studies. Some of the equipment is too delicate to permit casual use and some studies may require special expertise in experimental design, data analysis, and interpretation. In these cases, users typically collaborate with BR staff on their research projects.

Established Technologies

  • Circular dichroism (CD) spectroscopy
  • Steady-state and time-resolved fluorescence spectroscopy
  • Isothermal titration calorimetry (ITC)
  • Differential Scanning Fluorimetry
  • Liquid chromatography with high-resolution mass spectrometry detection (Q-TOF LC-MS-MS)
  • HPLC electrospray mass spectrometry (single quad LC-MS)
  • Dynamic light scattering (DLS)
  • Microscale thermophoresis (MST)
  • SwitchSense 
  • Mass photometry

User Guidelines

Some technologies are available as walk-up, some are available through collaboration. Details - at the web site.

To request services from this CCR core facility, please contact the Core Director/Facility Head.