Overview

The CPP is directly responsible for the pharmacokinetic (PK) analysis of numerous Phase I and II clinical trials conducted within the NCI. In addition, the CPP provides direct PK support for many studies performed elsewhere in the extramural community. The program provides bioanalytical support (LC-MS) and pharmacokinetic-pharmacodynamic (PK/PD) modeling and simulation of investigational agents or combination therapies to predict exposure-response in future trials (Pharmacometrics Core). The CPP can also assist with determining protein binding, drug-drug interactions, concentration-effect analysis, drug metabolism and routes of elimination for new anticancer agents.

Contact Details

Facility Head: William Douglas Figg, Sr., Pharm.D.
Phone: 301.402.3622
Email: wdfigg@helix.nih.gov
Address: Building 10, Room 5A01, Bethesda

Established Technologies

  • Bioanalytical support (LC-MS)
  • Pharmacokinetic analysis
  • Modeling of investigational agents or combination therapies
  • The CPP can also assist with determining protein binding, drug-drug interactions, concentration-effect analysis, drug metabolism and routes of elimination for new anticancer agents.

User Guidelines

The CPP is open to all NCI intramural clinical investigators.

Major Instrumentation

UV/Vis spectrophotometry

HPLC-UV

HPLC-FL

LC-MS

LC-MS/MS

Contact Information
Name:
Keith Schmidt
Title:
Pharmacologist
Address:
9000 Rockville Pike
Bethesda, MD 20892