NCI Clinical Pharmacology Program (CPP)

The CPP is directly responsible for the pharmacokinetic (PK) analysis of numerous Phase I and II clinical trials conducted within the NCI. In addition, the CPP provides direct PK support for many studies performed elsewhere in the extramural community. The program provides bioanalytical support (LC-MS) and pharmacokinetic-pharmacodynamic (PK/PD) modeling and simulation of investigational agents or combination therapies to predict exposure-response in future trials (Pharmacometrics Core). The CPP can also assist with determining protein binding, drug-drug interactions, concentration-effect analysis, drug metabolism and routes of elimination for new anticancer agents.

Established Technologies

• Bioanalytical support (LC-MS)
• Pharmacokinetic analysis
• Modeling of investigational agents or combination therapies
• The CPP can also assist with determining protein binding, drug-drug interactions, concentration-effect analysis, drug metabolism and routes of elimination for new anticancer agents.