Contact Information

Primary Contact

R. Mark Simpson
Program Director


9000 Rockville Pike
NIH Building 37
Bethesda, Maryland 20892


The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization and utilization of models of human disease. The initiative approach includes both applied research and collaborations aimed at developing new reagents, methods, and technologies in preclinical diagnostic medicine; thus enhancing capabilities to integrate molecular and systemic aspects of disease mechanisms. Designing and employing state of the art medical and pathology investigative tools to the study of animal models will help promote translational phenotype comprehension, and therefore improve model predictability for human cancer diseases.

List of Services

  • Training in comparative and molecular pathology
  • Research investigation and animal model validation
  • Developing molecular diagnostics and digital pathology for research

Established Technologies

  • Imaging
  • Optical bioluminescent imaging (Xenogen, Inc. IVIS camera system)
  • Training
  • Comparative Biomedical Scientist Training Program
  • Summer Internship Program in Biomedical Research for Veterinary Medical Students

Developing Technologies

  • Molecular Diagnostics
  • Development of novel immunohistochemical assays to probe for different markers on an array of tissues (e.g., human, primate, rodent)
  • Development of proteomic and other approaches useful in animals for defining disease or treatment response mechanisms
  • Animal Model Validation
  • Development/refinement of animal models in collaboration with other CCR investigators