The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization, and utilization of research models of human disease. The initiative approach includes both applied research and collaborations aimed at developing new reagents, methods, and technologies in preclinical diagnostic medicine; thus enhancing capabilities to integrate molecular and systemic aspects of disease mechanisms. Designing and employing state-of-the-art medical and pathology investigative tools to the study of models will help promote translational phenotype comprehension, and therefore improve model predictability for human cancer diseases.
List of Services
- Training in comparative and molecular pathology
- Research investigation and model validation
- Developing molecular diagnostics and digital pathology for research
Established Technologies
- Imaging
- Training
- Comparative Biomedical Scientist Training Program
- Summer Internship Program in Biomedical Research for Veterinary Medical Students
Developing Technologies
- Molecular Diagnostics
- Development of novel immunohistochemical assays to probe for different markers on an array of tissues for various species applications (e.g., human, primate, rodent)
- Development of proteomic and other approaches useful for defining disease or treatment response mechanisms
- Physiologic, microphysiologic, and integrative molecular tissue model validation and extrapolation for research translation
- Development/refinement of models in collaboration with other CCR investigators