NATIONAL CANCER INSTITUTE - CANCER.GOV

Contact Information


Primary Contact

Brenda Klaunberg, VMD
Animal Imaging Program Director

Location

Building 10, Room B1D200
Bethesda, MD 20850

Overview

The Mouse Imaging Facility (MIF) is a shared, trans-NIH intramural resource for animal imaging studies. MIF provides access to state-of-the-art radiological imaging methods optimized for mice, rats, other animals and tissue samples. MIF provides intellectual, technical and material support for investigators using the MIF imaging facilities. The MIF is supported by all institutes at the NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, the MIF resides within NINDS and is physically located in the NIH MRI Research Center (NMRC) in Building 10.

Established Technologies

High resolution preclinical anatomical and neuroimaging with MRI, Micro-CT and ultrasound including tumor locations, developmental defects, bone density. Some functional information is available with ultrasound, optical imaging and MRI such as cardiac function, blood flow dynamics, oxygenation.

Major Instrumentation

  • MRI: Bruker Biospec 9.4T/30 cm, includes cryoprobe option
  • MRI: Bruker 14T/4cm Vertical MRI Microimaging System
  • Micro CT in-vivo: Quantum GX (Revvity)
  • Micro CT ex-vivo: SkyScan 1272 (Bruker)
  • Optical Bioluminescence/Fluorescence: IVIS Spectrum (Revvity)
  • High-Frequency Ultrasound: Vevo3100 (FujiFilm VisualSonics)
  • Photoacoustic Imaging: Vevo LAZR-X (FujiFilm VisualSonics)
  • DEXA Body Composition scanner: Medikors Inalyzer (Microphotonics)
  • Functional Ultrasound: Iconeus One 

User Guidelines

MIF Resources are available to all intramural NIH investigators meeting the following requirements:

  • All personnel must pass MRI Safety training before working within the NMR Center. 
  • Live animal imaging must be approved in the PI’s ASP. 
  • Animal health status must be acceptable to MIF.
  • A completed “MIF Cover page” with SD signature approval for imaging time is required.
  • Details can be found here:  MIF Guidelines

Keywords

Animal MRI SystemBioluminescenceFluorescenceHigh Frequency UltrasoundMRIMagnetic Resonance ImagingMicro CTPhotoacoustic Imaginganimal imagingnih-corePreclinical ImagingMicro Computed Tomographyoptical imagingfunctional UltrasoundOptical BioluminescenceDEXA Body Composition scanner