The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell based assays, in vivo imaging studies, and translational research leading to better disease diagnosis and therapy. It comprises a core synthesis facility dedicated to the preparation of imaging probes, including radiolabeling for PET and SPECT applications, and a research component dedicated to the discovery of new imaging approaches and compositions.Established TechnologiesPROTACS - Proteolysis-targ… [learn more]

The facilities at AIM are available for use by the entire NIH intramural research community.While we welcome users with any size imaging project, AIM specializes in large, yearlong (or longer), collaborative research efforts with NIH labs – providing sample preparation, microscope operation and development, and data processing/analysis as needed. We take care of the imaging and processing so that you can focus on the biology.Established TechnologiesMicroscopeDescriptionSpatial ResolutionSpeed (frames/s)PhotodoseSampleInstant structured illumination microscope (ISIM)Fast super-resolution140nm… [learn more]

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement and analysis.BEPS is centrally located on the main NIH campus, and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms.Established TechnologiesElectron MicroscopyThe Electron Microscopy Unit provides instrumentation, training, and services for: immuno electron microscopy, electron tomography, and specimen preparation, including cryo-techniques.Micro A… [learn more]

The MIF was established as a pilot project to provide the NIH intramural community access to modern radiological imaging methods optimized for studying mice (and other animals) and to advance state-of-the-art small animal imaging. The MIF is supported by all Institutes at the NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, the MIF resides within NINDS and is physically located in the NIH MRI Research Center (NMRC) in Building 10.Established TechnologiesMIF provides intellectual, technical and material support for investigators using t… [learn more]

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, NMRF resides within NINDS. The NMR Center Steering Committee provides the direct oversight for NMRF activities.Service OfferingsProvide intellectual, technical and material support for investigators using its imaging and computer resources.MRI using a state-of-the-art 7.0 T human MRI system and other resources required for anatomical, functional an… [learn more]

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, mortality or unexpected findings. In addition, mouse phenotyping and transmission electron microscopy services are available. Established Technologies The Pathology Service offers a Mouse Phenotyping Service with comprehensive pathologic analysis for genetically engineered mice. The Service provides standardized gross and histopathologic … [learn more]