The NMR Facility for Biological Research operates six NMR spectrometers with proton resonance frequencies from 850 to 500 MHz. Four of the highest field spectrometers (850, 800, 700, 600) are equipped with helium cooled cryoprobes optimized for high-resolution experiments on biological samples in solutions. These high field instruments are dedicated to research projects conducted by laboratories within Center for Structural Biology. The second 600 MHz spectrometer is set up as reconfigurable development system with multiple probes allowing for high-resolution liquid state as well as biosolids Magic Angle Spinning (MAS) experiments and is sometimes used to perform experiments with special purpose probes.
The Facility operates a fully automated 500 MHz spectrometer designated as an “open access” instrument to all the FNLCR community. This spectrometer is equipped with broadband X-H/F type nitrogen cooled cryoprobe which is optimized for work on small molecule samples and serves as an analytical tool for many users – particularly from the Chemical Biology Laboratory.
Bruker 850
Bruker 800
Bruker 700
Bruker 600
Bruker 600 Phoenix
Bruker 500
The high field spectrometers (850, 800, 700, 600) are dedicated to research projects conducted by laboratories within Center for Structural Biology. The fully automated 500 MHz spectrometer designated as an “open access” instrument available to all of the Frederick National Laboratory for Cancer Research (FNLCR) community.