Genetics and Genomics

The Center for Inherited Disease Research (CIDR)'s  mission is to support the genetics community by providing high-quality, cutting-edge genomics services and technologies in order to expand our understanding of disease and catalyze discoveries that translate to patient care.  All NIH CIDR Program studies are supported by data sharing assistance. GWAS and sequencing studies are additionally provided both data cleaning services. GWAS studies include imputation services.Established TechnologiesSNP Genotyping, Using Illumina Infinium chemistries and Affymetrix Axiom chemistry, investigators hav… [learn more]

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA screens, informatics/pathway analysis and rigorous follow-up. Genome-wide siRNA screens for human and mice are available. Also routinely included in screens are miRNA mimic and inhibitor libraries. Resources: Screening Libraries Ambion Silencer Select Human Genome-Wide siRNA library targeting ~22,000 genes with th… [learn more]

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to bring genomic sequence to biology and medicine. We accomplish this by meeting with each NIH investigator to discuss the details of their project to determine which method(s) would work best. The most common types of sequencing projects include whole exome sequencing, RNA sequencing, custom capture sequencing, CHiP-seq, and whole genome sequencing. However, we are always inte… [learn more]