Established TechnologiesSNP GenotypingUsing Illumina Infinium chemistries and Affymetrix Axiom chemistry, investigators have a wealth of genotyping study design options available to them. We currently offer production scale linkage, GWAS and custom SNP genotyping services which utilize LIMS tracking, robotic automation and strict QC standards.SequencingWe currently offer production scale whole genome, whole exome and custom targeted sequencing services which utilize LIMS tracking, robotic automation, strict QC standards and automated primary, secondary and tertiary analyses. [learn more]

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA screens, informatics/pathway analysis and rigorous follow-up. Genome-wide siRNA screens for human and mice are available. Also routinely included in screens are miRNA mimic and inhibitor libraries. Resources Screening Libraries Ambion Silencer Select Human Genome-Wide siRNA library targeting ~22,000 genes with three… [learn more]

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to bring genomic sequence to biology and medicine. We accomplish this by meeting with each NIH investigator to discuss the details of their project to determine which method(s) would work best. The most common types of sequencing projects include whole exome sequencing, RNA sequencing, custom capture sequencing, CHiP-seq and whole genome sequencing. However, we are always interested in … [learn more]