Metabolomics

The Center for Clinical Cancer Metabolism provides infrastructure and expertise in the following focused areas of cancer metabolism research: 1) Three-phase sample preparation strategies designed to maximize the information that can be obtained from clinical and pre-clinical tissues and cells. 2) NMR-based multiple isotope-resolved metabolomics of polar and non-polar cell and tissue extracts. 3) Mass spectrometry-based targeted analysis of polar Single- and Multiple Isotope-labeled cell and tissue extracts. 4) Preclinical multinuclear NMR-based metabolic imaging of tumors and other tissues, in… [learn more]

Protein and Metabolite Characterization Core (PMCC), formerly known as the Protein Characterization Lab (PCL),  offers various technologies to CCR investigators to characterize proteins and metabolites. The core develops and applies state-of-the-art analytical technologies, primarily mass spectrometry, and liquid chromatography, to advance the understanding of cellular function at the protein, proteomics, metabolite, and metabolomic levels. It engages in both short and long-term collaborations based on the need of each project. It is operated by Leidos Biomedical Research Inc. on behalf of NC… [learn more]

The NIH Metabolomics Consortium (NIH-MC) is a shared research resource that performs metabolomics analysis (and related small molecule research) for investigators at all Institutes and Centers across the NIH Intramural Research Program. The NIH-MC is administered at NIEHS with participating laboratories at NIEHS, NIA, and NIAID. The NIH-MC was established in 2023 and continues to grow in the offerings provided, expertise, and participatory labs. Established Technologies Metabolomics measures the small molecules – endogenous and exogenous – that underpin biological changes in response to … [learn more]