NATIONAL CANCER INSTITUTE - CANCER.GOV

Collaborative Resources

Imaging and Microscopy

CCR Spatial Imaging Technology Resource (SpITR)
Bethesda, MD

Collaborative

Services Offered
Training Opportunities

The Spatial Imaging Technology Resource (formerly the Nanoscale Protein Analysis Section of the Collaborative Protein Technology Resource or CPTR) provides expertise and service in state-of-the-art protein analysis technologies to advance CCR research in basic discovery and translation/clinical studies. Applications include: Quantitative profiling of cell signaling and post-translational modification, Measurement of cytokine, metabolite and serum/plasma markers , Identification and validation of biomarkers & therapeutic targets, Assessment of on‐ and off‐target drug activity and pharm… [learn more]

Facility Head: Noemi Kedei, MD
Email: kedein@nih.gov
Phone: (240) 760-6804
CCR Volume Electron Microscopy (CVEM)
Frederick, MD

Collaborative

Services Offered

CCR VOLUME Electron Microscopy (CVEM) aims to develop new techniques in volume electron microscopy (vEM) and, in collaboration with CCR Investigators, apply these techniques to research cell biological questions well-suited for study by high-resolution 3D electron microscopy. CVEM, headed by Kedar Narayan, uses focused ion beam scanning electron microscopy (FIB-SEM), array tomography (AT), electron tomography (ET) and other complementary methods to visualize ultrastructural features of cells and tissues, including cell membranes, cellular organelles, and virus particles. CVEM is a CCR-dedicate… [learn more]

Group Leader: Kedar Narayan, Ph.D.
Email: kedar.narayan@nih.gov
Phone: (301) 846-5384
EIB Confocal Microscopy Facility
Bethesda, MD

Collaborative

Training Opportunities

EIB Microscopy Facility has following instruments: 1) Abberior STEDYCON super-resolution (STED) microscope; 2) Zeiss LSM 880-NLO confocal / two-photon system; 3) Yokogawa CSU-W1 spinning disck confocal microscope and 4) Zeiss AxioObserver Z1 wide field microscope. As a multi-user facility, the different instruments provide a wide range of imaging modes for EIB scientists, from standard immunohistochemistry, through brightfield and wide-field epifluorescence imaging, to highly complex live cell confocal microscopy and super-resolution STED imaging. LSM 880 microscope is capable of advanced … [learn more]

Facility Head: Jan Wisniewski
Email: jan.wisniewski@nih.gov
Phone: (240) 858-3605
NCI High-Throughput Imaging Facility (HiTIF)
Bethesda, MD

Collaborative

Services Offered
Training Opportunities

The NCI High-Throughput Imaging Facility (HiTIF) works in a collaborative fashion with NCI/NIH Investigators by providing them with the necessary expertise, instrumentation, and software to develop and execute advanced High-Throughput Imaging (HTI) assays. These can be paired to screen libraries of RNAi or CRISPR/Cas9 reagents to discover and characterize novel cellular pathways by functional genomics. In addition to functional genomics screens, HiTIF also develops HTI assays to extract and quantify single-cell information about the molecular mechanisms underlying rare or heterogeneous b… [learn more]

Facility Head: Gianluca Pegoraro
Email: gianluca.pegoraro@nih.gov
Phone: (240) 760-6696