Resource Repository

The Biological Products Core provides the AIDS research community with high-quality purified preparations of various strains of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV), economically prepared by leveraging the economy of scale. Materials provided include chemically inactivated virus prepared by treatment with Aldrithiol-2. This chemical inactivation method was developed by AIDS and Cancer Virus Program personnel and eliminates infectivity while preserving functional surface proteins, including envelope glycoproteins. This property makes them attractive prepara… [learn more]

Mouse models of human cancer have had a profound impact on our current understanding of the mechanisms of tumorigenesis and the pathways regulated by cancer-related genes. These models hold the promise of serving as critical tools in the discovery and testing of novel therapeutics to be used in the treatment and prevention of cancer. The Transgenic Mouse Model Laboratory (TMML) provides assistance to the scientific community with the generation of genetically engineered mice (GEM), offering a complete array of services aimed at the successful generation of tran… [learn more]

The NIA Nonhuman Primate (NHP) Core Facility maintains a colony of rhesus macaques at the National Institutes of Health Animal Center. Established in 2012, the Core's mission is to offer research services supporting multi-disciplinary translational aging projects.  Working with investigators, we develop experimental protocols to evaluate various aspects of NHP aging.  We provide all supportive care for the research animals, complete all regulatory requirements,  conduct in vivo experiments, and collect and organize study data.  The NIA IRP's 30 years of NHP research experience has made us… [learn more]

The mission of Human Brain Collection Core (HBCC) within the National Institute of Mental Health, Division of Intramural Programs (NIMH IRP) is to conduct and support research on brain and behavior, with the goal of reducing the burden of mental illness. HBCC is a national resource, providing unique opportunities in mental health research. Established Technologies The HBCC obtains human brain tissue and blood samples from deceased individuals diagnosed with major mental illnesses such as schizophrenia, depression, bipolar disorder, substance abuse, and their consequences (e.g., suicide), a… [learn more]