The BRB Preclinical Repository is a central repository that supplies reagents to the broad research community. This NCI-sponsored repository is managed by NCI's Biological Resources Branch (BRB).  The BRB Preclinical Repository stores cytokines, monoclonal antibodies, and other biologic reagents under carefully controlled conditions to ensure a uniform supply of high-quality reagents.  These reagents many be used for non-clinical research by qualified investigators at public, academic and non-profit institutions. There is no charge for the reagents, but investigators will be required to pay … [learn more]

The Central Repository provides the research community at the NCI with various cryogenic services, including low-temperature storage from +4° C to -196° C, controlled-rate freezing, computerized inventory and distribution of samples. The Central Repository is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Services may be provided to other NIH Institutes for specific projects upon request. Contacting This Facility: To contact this facility, please refer to the contact details below. Please do not send your request via CREx. … [learn more]

The Developmental Therapeutics Program (DTP) within NCI's Division of Cancer Treatment and Diagnostics (DCTD), has maintained a low temperature repository of transplantable in vivo-derived tumors and in vitro-established tumor cell lines from various species. This Tumor Repository, located at the National Cancer Institute in Frederick serves as a resource for viable, pathogen-screened experimental tumor lines, many of which are not available elsewhere. The Repository makes these materials available to qualified investigators as a service to the cancer research community. Please find the ma… [learn more]

DTP’s Natural Products Repository is the world’s largest storehouse of natural products. It houses close to >200,000 extracts from samples of more than 70,000 plants and >20,000 marine organisms collected from more than 29 countries, plus extracts of diverse bacteria and fungi. In addition the NCI Natural Products Repository also includes pre-fractionated natural products extracts created through the NCI Program for Natural Products Discovery. The pre-fractionated extract library has 500,000 partially-purified plated fractions, crated from NPB crude extracts, available for screening. The N… [learn more]

DTP maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. The Repository collection is a uniquely diverse set of more than 200,000 compounds that have been either submitted to DTP for biological evaluation or, in some cases, synthesized under DTP auspices. Samples obtained from the NCI/DTP Open Chemicals Repository are available at no cost except for shipping charges. Importantly, investigators should note that chemical structures of these substances are those assigned by the originator of the material an… [learn more]

The National Clinical Trials Network Biospecimen Banks (NCTN) receive, store, and distribute human cancer biospecimens collected on NCTN clinical trials. NCTN Biobanks provide cancer researchers with quality, well-annotated biospecimens and associated clinical information. The NCTN Biobanks house solid tumor biospecimens from all organ sites, as well as hematological malignancy specimens.Available Biospecimens Biospecimen types available include, but are not limited to:Formalin-fixed, paraffin-embedded (FFPE) tissueFresh frozen tissueWhole blood, serum, plasma, white blood cells, bone marro… [learn more]

The National Cancer Institute (NCI) has launched a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs) and in vitro patient-derived cell cultures (PDCs), including mixed cell populations, clonal cell lines, and fibroblast cell lines, to serve as a resource for public-private partnerships and for academic drug discovery efforts. These PDMs are early-passage and clinically-annotated with molecular information available in a public database for the extramural community. Additional models will continue to be added to the PDMR as they pass interna… [learn more]

The Specimen Resource Locator (SRL) is a biospecimen resource database designed to help researchers locate resources that may have the samples needed for their investigational use. This publicly searchable database includes information about biospecimen banks and sample procurement services. The specimens and samples come from non-commercial, either NCI or non-NCI-funded resources. Investigators can search the database and gain access to thousands of specimens of various tumor, organ, and preservation methods. Please submit all SRL inquiries using the “Contact the Expediter” button on t… [learn more]