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Search Results for: clone construction

Total Results Found: 50

Total Results Found: 50

Bioinformatics Resources for CCR Scientists: Input Data

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Bioinformatics

SnapGene can read alignment files from Clustal, GDE, MSF, NEXUS, PHYLIP, PIR, Selex, Stockholm. In addition, SnapGene can read files from the following programs: ApE (.ape), CLC (.clc), Clone Manager, DNA Strider, DNADynamo (.cow), DNASIS (. Read More...

CCR Protein Expression Laboratory (PEL)
Frederick, Maryland

Core Facility

The Protein Expression Laboratory produces proteins to help CCR investigators achieve their research goals with the lowest possible cost in the shortest time. PEL is operated by Leidos Biomedical Research Inc. on behalf of NCI Read More...

BTEP Lessons: Learning Objectives

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Bioinformatics

Understand the ggplot2 syntax. Learn the grammar of graphics for plot construction. Create simple, pretty, and effective figures.

BTEP Lessons: Learning Objectives

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Bioinformatics

Understand the ggplot2 syntax. Learn the grammar of graphics for plot construction. Create simple, pretty, and effective figures.

BTEP Coding Club: Background on volcano plot

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Bioinformatics

A volcano plot is a special case of a scatter plot. It is used in RNA sequencing analysis to visualize gene expression change versus statistical significance of gene expression change. The differential expression analysis results Read More...

BTEP Coding Club: Learning objectives

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Bioinformatics

This class provides an overview of the GitHub web interface and Git command line, which are tools used for code versioning. After this class, participants will Understand the importance of versioning Be able to perform Read More...

Turning discovery into health with the spatial biology community

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Bioinformatics

10/03/2023 - Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Significant advances in the field now allow high-parameter data collection (60+ targets); however, considerable expertise and capital are needed to validate Read More...

Bioinformatics for Beginners 2022: Common Aligners

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Bioinformatics

Most alignment algorithms rely on the construction of auxiliary data structures, called indices, which are made for the sequence reads, the reference genome sequence, or both. Mapping algorithms can largely be grouped into two categories Read More...

Data Visualization with R: Variable Types

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Bioinformatics

Before diving into the construction of bar plot, box & whisker plot, and histogram, we should do a quick review of the types of variables that we commonly work with in data analysis. Categorical variables Read More...

Data Visualization with R: Variable Types

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Bioinformatics

Before diving into the construction of bar plot, box & whisker plot, and histogram, we should do a quick review of the types of variables that we commonly work with in data analysis. Categorical variables Read More...

BTEP Coding Club: OPTIONAL: Visualizing rMATS output

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Bioinformatics

Getting rmats2sashimiplot git clone https://github.com/Xinglab/rmats2sashimiplot/ No installation required; however, conversion from Python2 to Python3 might be needed: ./rmats2sashimiplot/2to3.sh To run the program, use "python" Read More...

Partek Genomics Suite

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Partek Genomics Suite is a comprehensive suite for advanced statistics and interactive data visualization, specifically designed to reliably extract biological signals from noisy data.Partek Genomics Suite is a comprehensive suite of advanced statistics and Read More...

QIAGEN CLC Genomics Workbench

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QIAGEN CLC Workbench is a user-friendly solution for DNA, RNA and protein data sequence analysis. It houses tools for molecular biology and next generation sequencing (NGS) data analysis. QIAGEN CLC Genomics Workbench The CLC Genomics Read More...

CHTN Mid-Atlantic Division (University of Virginia)
Charlottesville, VA

Repositories

Trans NIH Facility

The Mid-Atlantic CHTN is one of six participating divisions of the Cooperative Human Tissue Network (CHTN) and is based in the Pathology Department at the University of Virginia. While primarily a resource for cancer researchers, Read More...

NIH Intramural Sequencing Center (NISC)
Rockville, MD

Trans NIH Facility

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to Read More...

July 2023 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Cores on CREx NIBIB BEPS Micro Analytical Immunochemistry Unit The Micro Analytical Immunochemistry Unit employs a variety Read More...

Mass Spectrometry for Proteins

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Mass Spectrometry Section of the Collaborative Protein Technology Resource (Bldg. 37) Core Capabilities: Identification of proteins in complexes, organelles, subcellular fractions, or fluids. Global relative protein quantitation. Quantitation by isotopic labeling of cells in culture (SILAC) Read More...

NCI Molecular Cytogenetics Core Facility
Frederick, MD

Core Facility

Molecular Cytogenetics Core Facility facilitates the assessment of structural and numerical genomic changes in pre-cancer and cancer research models. This core provides comprehensive support for the cytogenetic analysis of cells from human and research animal Read More...

Protein Expression Laboratory

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Protein Expression Laboratory The Protein Expression Laboratory develops, improves, and delivers protein-centric services. Our goal is to help client investigators achieve their research goals with the lowest possible cost in the shortest time. All PEL Read More...

Bulk RNA Sequencing Analysis using Partek Flow

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Bioinformatics

11/19/2024 - Partek Flow enables scientists to construct analysis workflows for multi-omics sequencing data including DNA, bulk and single cell RNA, spatial transcriptomics, ATAC and ChIP. It is a point-and-click software hosted on Biowulf, the NIH Read More...

Data Visualization with R: row-wise scaling

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Bioinformatics

Scaling is important during cluster analysis because it reduces the influence that variables with high magnitude values will have on distance. (https://medium.com/analytics-vidhya/why-is-scaling-required-in-knn-and-k-means-8129e4d88ed7). A common method for scaling is Read More...

NCI Center for Advanced Preclinical Research (CAPR)
Frederick, MD

Collaborative

The Center for Advanced Preclinical Research (CAPR) specializes in evaluating the efficacy of preclinical compounds, existing drugs, or biologics (therapeutics) in genetically engineered mouse models, GEM-derived allograft (GDA) models, or patient-derived mouse xenografts (PDX). We Read More...

October 2021

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CREx News & Updates October 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGLIGHTS Learn more about services from the CPTR Read More...

CCR Sequencing Facility
Frederick, MD

Core Facility

The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at Read More...

Bioinformatics for Beginners 2022: Alignment

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Bioinformatics

Alignment RNASeq Mapping Challenges The majority of mRNA derived from eukaryotes is the result of splicing together discontinuous exons, and this creates specific challenges for the alignment of RNASEQ data. Mapping Challenges Reads not perfect Read More...

Data Visualization with R: Lesson 4

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Bioinformatics

/* Whole document: */ body{ font-family: Times; font-size: 16pt; } Stat Transformations: Bar plots, box plots, and histograms Objectives Review the grammar of graphics template Learn about the statistical transformations inherent to geoms Review data types Create bar Read More...

Data Visualization with R: Lesson5

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Bioinformatics

Visualizing clusters with heatmaps Objectives Introduce the heatmap and dendrogram as tools for visualizing clusters in data. Learn how to work with the package pheatmap . Learn how to save a non-ggplot2 plot. Introduce ggplotify to Read More...

Visualizing Complex Networks using Cytoscape

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Bioinformatics

09/01/2016 - This 2-day workshop, including a BYOD (Bring Your Own Data) exercise, will provide an introduction and hands-on training for Cytoscape, which is an open source software platform for visualizing  networks and integrating these networks Read More...