Resource Repository

The Biological Products Core provides the AIDS research community with high-quality purified preparations of various strains of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV), economically prepared by leveraging the economy of scale. Materials provided include chemically inactivated virus prepared by treatment with Aldrithiol-2. This chemical inactivation method was developed by AIDS and Cancer Virus Program personnel and eliminates infectivity while preserving functional surface proteins, including envelope glycoproteins. This property makes them attractive prepara… [learn more]

The BRB Preclinical Biologics Repository is a central repository that supplies reagents to the broad research community. This NCI-sponsored repository is managed by NCI's Biological Resources Branch (BRB) in the Development Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD). The BRB Preclinical Biologics Repository stores cytokines, monoclonal antibodies, and other biologic reagents under carefully controlled conditions to ensure a uniform supply of high-quality reagents. These reagents may be used for non-clinical research by qualified investigators at public,… [learn more]

The Mid-Atlantic CHTN is one of six participating divisions of the Cooperative Human Tissue Network (CHTN) and is based in the Pathology Department at the University of Virginia. While primarily a resource for cancer researchers, samples provided by the CHTN support projects in many biomedical and basic science fields. In addition to tissue and biofluid specimens, the Mid-Atlantic Division specializes in the construction and distribution of tissue microarrays (TMAs). TMAs allow immunohistochemical and colorimetric staining for biomarkers on many samples in paralle… [learn more]

The CHTN is a unique NCI-supported resource that provides human tissues and fluids from routine procedures to investigators who utilize human biospecimens in their research. Unlike tissue banks, the CHTN works prospectively with each investigator to tailor specimen acquisition and processing to meet their specific project requirements. High-quality biospecimens are available from surgeries, autopsies, and other routine procedures. Types of preservation methods available include fresh, frozen, floating fixative, RNAlater, and paraffin-embedded. The CHTN is NCI-subsidized, allowing for bel… [learn more]

The Developmental Therapeutics Program (DTP) within NCI's Division of Cancer Treatment and Diagnostics (DCTD), has maintained a low temperature repository of transplantable in vivo-derived tumors and in vitro-established tumor cell lines from various species. This Tumor Repository, located at the National Cancer Institute in Frederick serves as a resource for viable, pathogen-screened experimental tumor lines, many of which are not available elsewhere. The Repository makes these materials available to qualified investigators as a service to the cancer research community. Please find the ma… [learn more]

DTP’s Natural Products Repository is the world’s largest storehouse of natural products. It houses close to >200,000 extracts from samples of more than 70,000 plants and >20,000 marine organisms collected from more than 29 countries, plus extracts of diverse bacteria and fungi. In addition, the NCI Natural Products Repository also includes pre-fractionated natural products extracts created through the NCI Program for Natural Products Discovery. The pre-fractionated extract library has 500,000 partially-purified plated fractions, created from NPB crude extracts, available for screening. The… [learn more]

DTP maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. The Repository collection is a uniquely diverse set of more than 200,000 compounds that have been either submitted to DTP for biological evaluation or, in some cases, synthesized under DTP auspices. Samples obtained from the NCI/DTP Open Chemicals Repository are available at no cost except for shipping charges. Importantly, investigators should note that chemical structures of these substances are those assigned by the… [learn more]

The Central Repository provides the research community at the NCI with various cryogenic services, including low-temperature storage from +4° C to -196° C, controlled-rate freezing, computerized inventory and distribution of samples. The Central Repository is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Services may be provided to other NIH Institutes for specific projects upon request. Contacting This Facility: To contact this facility, please refer to the contact details below. Please do not send your request via CREx. List … [learn more]

The Mouse Modeling Core assists NIH investigators by generating and preserving genetically-engineered mouse strains. Services include scientific consultation, gene-targeting in mouse embryonic stem cells, micro-injection of nucleic acids, proteins, or ES cells into mouse embryos, in vitro fertilization, cryopreservation of germplasm, and regeneration of mice from frozen stocks. The MMC also interfaces with the Genome Modification Core to generate genetically or epigenetically-altered lines of mice using CRISPR and other nuclease-based methods (TALENS, Zn Fingers). The NCI Mouse Repository… [learn more]

The National Clinical Trials Network Biospecimen Banks (NCTN) receive, store, and distribute human cancer biospecimens collected on NCTN clinical trials. NCTN Biobanks provide cancer researchers with quality, well-annotated biospecimens and associated clinical information. The NCTN Biobanks house solid tumor biospecimens from all organ sites, as well as hematological malignancy specimens. Available Biospecimens Formalin-fixed, paraffin-embedded (FFPE) tissue, Fresh frozen tissue, Whole blood, serum, plasma, w… [learn more]

The National Cancer Institute (NCI) is developing a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), patient-derived organoids (PDOrg), and in vitro patient-derived tumor cell cultures (PDCs) and cancer-associated fibroblasts (CAFs). These models serve as a resource for public-private partnerships and for academic drug discovery efforts. These PDMs are clinically annotated with molecular information available in an easily accessible database available to the extramural community. List of Services: … [learn more]

The AgingResearchBiobank was officially launched in January 2019 with a mission to provide a state-of-the-art inventory system for the storage, maintenance, and distribution of de-identified biospecimens and associated phenotypic, clinical, and imaging data from numerous NIA-funded longitudinal studies and clinical trials on aging with the broader scientific community worldwide. It aims to foster compliance with NIH/NIA resource-sharing policies using FAIR principles and accelerate scientific advances to ultimately help extend the healthy, active years o… [learn more]

With specimens that span neurological, neuropsychiatric, and neurodevelopmental diseases and disorders, the NBB serves as a central point of access to the world-class collections of our six biorepositories. In addition, the NBB provides researchers with a wealth of resources to facilitate their research, including medical records and clinical data sets (when available) as well as access to quality metrics and best practices used by each site. Established Technologies The NIH NeuroBioBank contains an inventory of specimens that are available through its b… [learn more]

The mission of Human Brain Collection Core (HBCC) within the National Institute of Mental Health, Division of Intramural Programs (NIMH IRP) is to conduct and support research on brain and behavior, with the goal of reducing the burden of mental illness. HBCC is a national resource, providing unique opportunities in mental health research. Established Technologies The HBCC obtains human brain tissue and blood samples from deceased individuals diagnosed with major mental illnesses such as schizophrenia, depression, bipolar disorder, substance abuse, and their consequ… [learn more]