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Search Results for: natural product libraries

Total Results Found: 127

DTP Natural Products Repository
Frederick, MD

Repositories

Trans NIH Facility

DTP’s Natural Products Repository is the world’s largest storehouse of natural products. It houses close to >200,000 extracts from samples of more than 70,000 plants and >20,000 marine organisms collected from more than 29 countries, plus extracts Read More...

R Introductory Series: Loading the libraries

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Bioinformatics

To begin plotting, let's load our tidyverse library. #load libraries library(tidyverse) # Tidyverse automatically loads ggplot2 ## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ── ## ✔ dplyr 1.1.3 ✔ readr 2.1.4 ## ✔ forcats 1.0.0 ✔ stringr 1.5.0 ## ✔ ggplot2 3.4.4 ✔ tibble 3.2.1 ## ✔ lubridate 1.9.3 ✔ tidyr 1.3.0 ## ✔ purrr 1.0.2 ## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ── ## ✖ dplyr:: Read More...

Data Visualization with R: Load the libraries

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Bioinformatics

There are multiple ways to combine figures using R. In this lesson, we will learn how to combine figures primarily with patchwork . Though, we will also learn some components of cowplot . To get started, load Read More...

Data Visualization with R: Load the libraries

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Bioinformatics

There are multiple ways to combine figures using R. In this lesson, we will learn how to combine figures using two different R packages cowplot and patchwork , beginning with cowplot . To get started, load the Read More...

R Introductory Series 2023: Loading the libraries

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Bioinformatics

To begin plotting, let's load our tidyverse library. #load libraries library(tidyverse) # Tidyverse automatically loads ggplot2 ## ── Attaching packages ─────────────────────────────────────── tidyverse 1.3.1 ── ## ✔ ggplot2 3.3.6 ✔ purrr 0.3.4 ## ✔ tibble 3.1.7 ✔ dplyr 1.0.9 ## ✔ tidyr 1.2.0 ✔ stringr 1.4.0 ## ✔ readr 2.1.2 ✔ forcats 0.5.1 ## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ── ## ✖ dplyr::filter() masks stats:: Read More...

Bioinformatics for Beginners 2022: What is a GO term?

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Bioinformatics

GO terms provide information about a gene product GO terms as a vocabulary are species agnostic, but there are species constraints ontology and annotations are updated regularly computer readable - suitable for bioinformatics GO integrates Read More...

Data Visualization with R: Libraries

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Bioinformatics

In this lesson, we will continue to use the ggplot2 package for plotting. To use ggplot2, we first need to load it into our R work environment using the library command. library ( ggplot2 )

Data Visualization with R: Libraries

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Bioinformatics

In this lesson, we will be using several external R packages. To utilize these, we need to first load them into our R working environment using the library command. library(ggplot2) #for plotting library(tidyr) # Read More...

Data Visualization with R: Load the libraries

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Bioinformatics

library(pheatmap) ## for heatmap generation library(tidyverse) ## for data wrangling library(ggplotify) ## to convert pheatmap to ggplot2 library(heatmaply) ## for constructing interactive heatmap

Data Visualization with R: Load the libraries

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Bioinformatics

library(pheatmap) ## for heatmap generation library(tidyverse) ## for data wrangling library(ggplotify) ## to convert pheatmap to ggplot2 library(heatmaply) ## for constructing interactive heatmap

Molecular Targets Program (MTP)
Frederick, MD

Collaborative

The Molecular Targets Program (MTP) is an organizational entity within the Center for Cancer Research (CCR) at NCI. The MTP provides the focus and infrastructure to enable CCR tenured and tenure-track Principal Investigators to initiate Read More...

Using MATLAB and Python Together

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Bioinformatics

10/16/2024 - In this webinar, attendees will learn to call MATLAB from Python and to call Python libraries from MATLAB.  In addition, they will learn how to use MATLAB’s Python integration to improve the compatibility Read More...

Getting Started with R on Biowulf

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Bioinformatics

07/13/2023 - In Lesson 2 of Toward Reproducibility with R on Biowulf , partipants will learn about ways to use R on Biowulf. The focus will be on interactively working with R on Biowulf. Two different ways of Read More...

NCI Center for Structural Biology: Protein Technology Core
Frederick, MD

Collaborative

The primary objective of the Protein Technology Core (PTC) is to establish an experimental screening pipeline for single-domain antibodies termed nanobodies. Nanobodies are antibody fragments consisting of a single monomeric variable antibody domain. The PTC, Read More...

NCI LASP Genome Modification Core (GMC)
Frederick, MD

Core Facility

NCI LASP Genome Modification Core (GMC) is a CCR-dedicated facility that provides advice, training, and reagents to NCI scientists seeking to utilize CRISPR and other nucleases to generate genome modifications in primary cells, cell lines, Read More...

NCATS Functional Genomics Laboratory
Rockville, MD

Core Facility

Trans NIH Facility

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA Read More...

DTP Repository of Chemical Agents
Rockville, MD

Repositories

Trans NIH Facility

DTP maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. The Repository collection is a uniquely diverse set of more than 200,000 compounds that have been Read More...

Antibody Engineering Program
Bethesda, MD

Collaborative

The Antibody Engineering Program (AEP) is located at the Laboratory of Molecular Biology, which is part of the Center for Cancer Research (CCR), an intramural program at the National Cancer Institute (NCI). AEP focuses on Read More...

Past Seminars

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Confocal

2024 Date: Tuesday, October 15, 2024 Time and Location: 11 am EST, ZOOM (INVITATION BY LMIG LIST SERVER) Speaker: Dr. Diego Presman (U Buenos Aires) Title: “Insights on Glucocorticoid Receptor Activity Through Live Cell Imaging” Summary: Eucaryotic transcription factors ( Read More...

2024 BRAIN NeuroAI Workshop

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Bioinformatics

11/12/2024 - Join us at the upcoming hybrid NIH BRAIN NeuroAI Workshop on November 12 and 13, with virtual access to in-person panels and discussions at the NIH Campus in Bethesda, MD. Artificial intelligence (AI) is reshaping technology Read More...

Data Types in R and RStudio

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Bioinformatics

10/11/2023 - This session focuses on R data types and data structures. In R, more advanced libraries (code) may require data to be a particular data type or data structure to perform a function or analysis. Read More...

Bioinformatics for Beginners 2022: Terms to know

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Bioinformatics

Normalization - the process of scaling data to account for uncontrolled factors affecting variation. Effect size - "the quantitative measure of the magnitude of a phenomenon" (Biostar Handbook). P-value - "the probability Read More...

Bioinformatics for Beginners 2022: Raw Sequence Cleanup

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Bioinformatics

Trim and/or filter sequence to remove sequencing primers/adaptor and poor quality reads. Example programs: FASTX-Toolkit is a collection of command line tools for Short-Reads FASTA/ FASTQ files preprocessing.
 SeqKit is an ultrafast comprehensive Read More...

MATLAB with Python

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Bioinformatics

07/13/2023 - MATLAB provides two-way integration with many programming languages such as Python, which allows for greater collaboration between investigators. This webinar will cover how to call MATLAB from Python and how to call Python libraries Read More...

R Introductory Series 2023: Introducing ggplot2

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Bioinformatics

ggplot2 is a R graphics package from the tidyverse collection. It allows the user to create informative plots quickly by using a 'grammar of graphics' implementation, which is described as "a coherent system for Read More...

May 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural Core Resources NHGRI Flow Cytometry Core The Core performs high quality single cell analysis through the Read More...

February 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Trans-NIH Metabolomics Core (TNMC) The TNMC is a shared research resource that provides targeted Read More...

March 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural CryoEM (NICE) Consortium NICE provides NCI, NIAID, NIEHS, NICHD, NIDCR, NEI, and NIA investigators with Read More...

April 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Extramural Common Fund Resources Metabolomics Workbench Developed by the NIH Metabolomics Common Fund's National Metabolomics Data Repository ( Read More...

Antibody​​ Engineering Program

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The Antibody Engineering Program (AEP) is part of the Center for Cancer Research (CCR) at the National Cancer Institute (NCI). The program focuses on generating therapeutic antibodies by phage display technology, including human antibodies and Read More...

NIH Intramural Sequencing Center (NISC)
Rockville, MD

Trans NIH Facility

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to Read More...

Biopharmaceutical Development Program (BDP)
Frederick, MD

Collaborative

The Biopharmaceutical Development Program (BDP) provides resources for the development of investigational biological agents. The BDP supports feasibility through development and Phase I/II cGMP manufacturing plus regulatory documentation.The BDP was established in 1993. We Read More...

Pediatric Oncology Branch: Behavioral Health Core
Bethesda, MD

Collaborative

The Behavioral Health Core (BHC) is comprised of the two separate but interrelated components: Psychosocial Support and Research Program, and, Health Psychology and Neurobehavioral Research Program., These teams provide specialized expertise, such as patient-reported and Read More...

AI for Clinical Care Workshop

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Bioinformatics

04/21/2024 - Looking for an introduction to artificial intelligence (AI) or an opportunity to expand on what you already know? Attend this workshop hosted by the NIH-funded Bridge2AI CHoRUS network and the University of Florida Read More...

R Introductory Series: Object data types

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Bioinformatics

The data type of an R object affects how that object can be used or will behave. Examples of base R data types include numeric, integer, complex, character, and logical. R objects can also have Read More...

R Introductory Series: Introducing ggplot2

Web Page

Bioinformatics

ggplot2 is an R graphics package from the tidyverse collection. It allows the user to create informative plots quickly by using a 'grammar of graphics' implementation, which is described as "a coherent system for Read More...

Bioinformatics for Beginners 2022: Data Analysis

Web Page

Bioinformatics

Data Analysis Here are a pair of examples of RNASEQ complete workflows RNASEQ Pipeline from NCI CCBR https://github.com/CCBR/Pipeliner/blob/master/RNASeqDocumentation.pdf RNASEQ Nextflow Pipeline from nf-core https://nf-co.re/rnaseq Read More...

R or Python: Which should I learn?

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Bioinformatics

A common question posed to the Bioinformatics Training and Education Program (BTEP) is “How can I learn R and Python to analyze my data?”. First, it’s important to state that learning any programming language Read More...

Data Visualization with R: The Data

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Bioinformatics

In this lesson we will use two different sets of data. First, we will use data available with your base R installation, the iris data set, which is stored in object iris . These data include Read More...

R Introductory Series 2023: Object data types

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Bioinformatics

R objects have certain attributes, and these attributes will be important for how they can interact with certain methods / functions. Understanding the mode (storage type) or the class of an object will be important for Read More...

November 2021

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CREx News & Updates November 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the NINDS Quantitative Magnetic Resonance Imaging Core. NINDS Read More...

Visium Spatial Gene Expression Technology

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What is Visium FFPE v2 with CytAssist? Visium FFPE v2 is sequencing-based spatial profiling technology developed by 10x Genomics. This assay can take mouse or human tissue sections on normal glass slides as input and Read More...

NCI Synthetic Biologics Core
Frederick, MD

Core Facility

The research conducted within the Synthetic Biologics Core (SBC) Facility has a dual role: Generate chemical biology tools and drug candidates for molecular targets identified by NCI research groups, Develop novel effective methods and tools Read More...

NCI High-Throughput Imaging Facility (HiTIF)
Bethesda, MD

Collaborative

The NCI High-Throughput Imaging Facility (HiTIF) works in a collaborative fashion with NCI/NIH Investigators by providing them with the necessary expertise, instrumentation, and software to develop and execute advanced High-Throughput Imaging (HTI) assays. These Read More...

August 2021

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CREx News & Updates August 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...

CCR Protein Characterization Laboratory (PCL)
Frederick, MD

Core Facility

Protein Characterization Laboratory (PCL) offers various technologies to CCR investigators to characterize proteins and metabolites. The laboratory develops and applies state-of-the-art analytical technologies, primarily mass spectrometry, liquid chromatography, and Surface Plasmon Resonance (SPR), to advance Read More...

STRIDES Initiative
Bethesda, MD

Trans NIH Facility

The Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) Initiative The STRIDES Initiative aims to help NIH and its institutes, centers, and offices (ICOs) accelerate biomedical research by reducing barriers in utilizing Read More...

CCR Genomics Core
Bethesda, MD

Core Facility

The CCR Genomics Core is located in Building 41 on the NIH Bethesda campus. The primary goal of the Core is to provide investigators from CCR/NCI and other NIH Institutes access to genomic technologies and Read More...

CCR Sequencing Facility
Frederick, MD

Core Facility

The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at Read More...

Multi-Angle Light Scattering (MALS)

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Back Services: We offer a limited sample processing service using standard SEC-MALS and FFF protocols.  This service is intended for the occasional users of this system.  Researchers who expect to use this instrument Read More...

R Introductory Series: Basics of R Programming

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Bioinformatics

Objectives To understand some of the most basic features of the R language including: Creating R objects and understanding object types Using mathematical operations Using comparison operators Creating, subsetting, and modifying vectors By the end Read More...

Bioinformatics for Beginners 2022: RNA-SEQ Overview

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Bioinformatics

RNA-SEQ Overview What is RNASEQ ? RNA-Seq (RNA sequencing), uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment. (Wikipedia) Strictly speaking this could be any Read More...

Bioinformatics for Beginners 2022: B4b 2022 rnaseq jw

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Bioinformatics

This page uses content directly from the Biostar Handbook by Istvan Albert. Obtain RNA-seq test data. The test data consists of two commercially available RNA samples: Universal Human Reference (UHR) and Human Brain Reference (HBR) . Read More...

Bioinformatics for Beginners 2022: 18. BLAST copy

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Bioinformatics

This page uses content directly from the Biostar Handbook by Istvan Albert. Remember to activate the bioinformatics environment and create a directory for today's work. conda activate bioinfo mkdir blast cd blast What is Read More...

Data Visualization with R: Lesson 4

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Bioinformatics

/* Whole document: */ body{ font-family: Times; font-size: 16pt; } Stat Transformations: Bar plots, box plots, and histograms Objectives Review the grammar of graphics template Learn about the statistical transformations inherent to geoms Review data types Create bar Read More...

Data Visualization with R: Lesson5

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Bioinformatics

Visualizing clusters with heatmaps Objectives Introduce the heatmap and dendrogram as tools for visualizing clusters in data. Learn how to work with the package pheatmap . Learn how to save a non-ggplot2 plot. Introduce ggplotify to Read More...

R Introductory Series 2023: ggplot2 Continued

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Bioinformatics

Objectives Review the grammar of graphics template. Learn about the statistical transformations inherent to geoms. Learn more about fine tuning figures with labels, legends, scales, and themes. Learn how to save plots with ggsave() . Review Read More...

R Introductory Series 2023: R Basics

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Bioinformatics

R basics Objectives : To understand some of the most basic features of the R language including: Creating R objects and understanding object types Using mathematical operations Using comparison operators Creating, subsetting, and modifying vectors By Read More...