Mutation Detection:For PCR and Sanger sequencing both testing and bioinformatics interpretation are conducted. This method is currently being used in patients with chronic granulomatous disease (CGD), WHIM syndrome, and other autoimmune disorders. Because Sanger is a “general method,” it can also be and has been used for other mutation detection, including assays for inherited diseases and cancer-related genes, as well as verification of next-generation sequencing discoveries. Assays can be optimized for any new gene(s) of interest.  We perform traditional polymerase chain reaction a… [learn more]

The Clinical Support Laboratory offers processing, tracking, and testing of a broad range of clinical samples. Support can begin at the early stages of clinical trial development to aid in developing a comprehensive strategy for sample collection, processing, and testing with a special emphasis on immunologic testing. The lab collaborates with partners to develop customized assays or transfer existing assay technology with assay validation, data analysis and interpretation of results. Processing specializes in PBMC isolation and controlled rate freezing, ELISA based biomarker testing, and mult… [learn more]

Laboratory of Cell Mediated Immunity offers a spectrum of bioassays to assess cellular responses to antigens and mitogens including ELISPOT, cytotoxicity assays and proliferation assays.Established TechnologiesElispot AssaysDual or Triple Color Fluorospot Assays
Murine ImmunoassaysCytotoxic T cell assays (Chromium Release Assays)
Antigen and mitogen-induced cell proliferation
Mixed Lymphocyte Reactions
Antibody-Dependent Cell-Mediated Cytotoxicity
Cell Metabolic Analysis via Seahorse
In vitro Stimulation/Cytokine Induction     [learn more]

The Clinical Flow Cytometry Laboratory provides extensive support for NCI clinical protocols by providing diagnostic testing for leukemia and lymphoma in patients either on NCI clinical protocols or undergoing testing to determine eligibility for NCI protocols. The Unit provides clinical flow cytometric evaluation of blood, bone marrow, fine needle aspirates, tissue biopsies and body fluids for hematolymphoid neoplasia in NCI and NIH patients. The majority of flow cytometric testing performed by the Unit involves detection of minimal residual disease (patients are status post-therapy at ou… [learn more]

The goal of Artificial Intelligence Resource (AIR) is to make AI tools available to Clinical Cancer Research (CCR) investigators. The strength of AI is that algorithms can be trained to seek specific information that may scientifically or clinically important. AIR will mainly focus on “Computer Vision” which analyzes medical images, such as radiologic, digital pathology, video/endoscopy and optical imaging among others. Examples of potential projects include developing better screening, detection methods or predictive markers, or improving procedures among many others. Both clinical … [learn more]

The Blood Processing Core monitors viral load in patients with HIV and performs sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease, or other diseases associated with immunologic dysfunction. The core collects clinical specimens from inpatient units and clinics within the National Institutes of Health Clinical Center. We then oversee the processing and cryopreservation of human serum, plasma, peripheral blood mononuclear cells, and other specimens. Our technicians are also trained and qualified to execute preclinical animal protocols and ro… [learn more]

The National Institutes of Health (NIH) has a Gammacell 1000 Elite Sealed Source Irradiator located on the main campus in Bethesda, MD. [learn more]

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies CIPS can process most modern imaging modalities such as MR, CT, PET and Ultrasound in anatomical regions from the hand to the heart. The CIPS lab currently offers services in seven exam categories: IP Dynamic Enhancement Dynamic Enhancement MRI (DEMRI) is a type of MRI study in which intravenous contrast is administered to… [learn more]

The Department of Laboratory Medicine provides state-of-the-art laboratory testing in support of Clinical Center patient care and will serve as a center of excellence in research and training in laboratory medicine, particularly in areas which utilize the unique strengths of the National Institutes of Health.GoalsWe are committed to the following goals:Respectful, compassionate, and high quality patient careHigh standards of clinical laboratory practice and efficiencyOptimal support of clinical research protocolsExcellence in applied and medical researchProfessional and career growth of staff … [learn more]

The goal of these studies is to develop novel methods to assess the quality of cellular therapies. Traditional analytic assays including ELISA, flow cytometry, and ELISPOT have many limitations. Better assays are needed to assess the complex and multiple functions of cellular therapy products, some of which are not well understood. Gene expression profiling using microarray technology has been widely and effectively used to assess changes of cells in response to stimuli and to classify cancers. Preliminary studies have shown that the expression of noncoding micro RNA which play an important ro… [learn more]

Radiology and Imaging Sciences provides imaging services for National Institutes of Health (NIH) Clinical Center patients participating in research protocols conducted by the various NIH institutes. Services include X-rays, fluoroscopy, ultrasound, magnetic resonance imaging (MRI) scans, computed tomography (CT) scans, and interventional radiology (special procedures).Radiology also conducts research studies of clinical imaging procedures and offers training in biomedical imaging research.Established TechnologiesRadiologyBody Imaging (conventional x-ray, ultrasound, MRI and CT)Interventional … [learn more]

The Metabolic Clinical Research Unit (MCRU) opened in 2007 as a key component of the Strategic Plan for NIH Obesity Research . The NIDDK worked closely with the Clinical Center to design the Unit, which houses state-of-the-art facilities and equipment for a wide range of metabolic clinical research studies. The MCRU brings together experts in a wide range of fields including metabolism, endocrinology, nutrition, cardiovascular biology, gastroenterology, hepatology, genetics, and behavioral sciences. It supports protocols designed by researchers from across all NIH institutes investigating … [learn more]

The Neurorehabilitation and Biomechanics Research Section (also referred to as the NAB LAB) is a multidisciplinary group of highly qualified scientists, clinical and technical staff, and trainees with diverse backgrounds including medical, physical therapy, neuroscience and biomedical engineering expertise.Clinical ServicesClinical services include comprehensive physical and functional assessments by Certified Adult and Pediatric Physical Medicine and Rehabilitation Medicine physicians and our team of physical therapists. Based on this initial assessment additional evaluations may be recom… [learn more]

The NIH Clinical Center Pharmacy Department provides pharmaceutical care to inpatients and outpatients on NIH intramural research protocols at the NIH Clinical Center. The Clinical Center facility encompasses 200 inpatient beds, 93 day-hospital stations, and 15 clinics. Clinical Center pharmacy staff provide sophisticated research support to health care providers as well as clinical investigators. Pharmacists conduct and participate in research programs that enhance knowledge regarding investigational drugs and new uses of commercially available agents.The Pharmacy Department's Investigational… [learn more]

The PET Department at the NIH Clinical Center has three PET scanners dedicated to clinical research. In addition, the facility has three medical cyclotrons and 10 hot cells to produce a wide variety of positron-emitting radiopharmaceuticals. A new cGMP Facility for production of radiopharmaceuticals will soon be put into operation. The department is staffed by a dedicated team of cyclotron engineers, radiochemists, healthcare providers, and scientists. Positron emission tomography (PET) is an imaging technique that uses radioactive substances injected into patients to provide images of t… [learn more]

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, NMRF resides within NINDS. The NMR Center Steering Committee provides the direct oversight for NMRF activities.Service OfferingsProvide intellectual, technical and material support for investigators using its imaging and computer resources.MRI using a state-of-the-art 7.0 T human MRI system and other resources required for anatomical, functional an… [learn more]

The Behavioral Health Core provides specialized research support to NCI clinical trials using neuropsychological and patient-reported outcome measures and develops protocols to investigate specific neurobehavioral and psychosocial effects of chronic illness.The Behavioral Health Core provides specialized research support to NCI clinical trials using neuropsychological and patient-reported outcome measures and develops protocols to investigate specific neurobehavioral and psychosocial effects of chronic illness. Contacting This Facility:Please refer to the contact details below. Please do … [learn more]