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Bioinformatics
07/07/2020 - In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative biomarkers that can Read More...
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Bioinformatics
07/07/2020 - In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative biomarkers that can Read More...
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What is Visium FFPE v2 with CytAssist? Visium FFPE v2 is sequencing-based spatial profiling technology developed by 10x Genomics. This assay can take mouse or human tissue sections on normal glass slides as input and Read More...
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Bioinformatics
01/24/2024 - Dear colleagues, Please join us on Wed., Jan. 24 when Dr. Avi Ma’ayan from the Icahn School of Medicine at Mount Sinai will demonstrate how to use these tools to access hundreds of thousands Read More...
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Bioinformatics
Separate the gene abbreviation from the Ensembl ID in column 1 using separate() . Save the output to a new object named dmat2 . {{Sdet}} Solution }. #separate gene abbreviation from ensembl id dmat2% select(1:2) dmat2% select(!gene_abb) {{ Read More...
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Bioinformatics
Lesson 12: RNA sequencing review 1 Learning objectives Here, we will do a quick review of what we have learned about RNA sequencing in Lessons 8 through 11. Accessing the Biostar handbook The URL for the Biostar handbook is Read More...
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Bioinformatics
DAVID can also generate gene clusters where those gene that cluster together share common annotations. We can view the cluster information as a heatmap where green represents an association between the gene and an annotation. Read More...
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Bioinformatics
To use various tools for functional analysis, you will need a list of annotated genes. Gene annotations come in a variety of flavors and not all flavors are compatible with every tool. For example, Gene Read More...
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Bioinformatics
What is one way we could use to visualize gene expression? {{Sdet}} Answer{{Esum}} We can use a heatmap which plots gene expression values on a color scale and allows us to discern gene expression Read More...
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Bioinformatics
To use various tools for functional analysis, you will need a list of annotated genes. Gene annotations come in a variety of flavors and not all flavors are compatible with every tool. For example, Gene Read More...
Bethesda, MD
Core Facility
The core provides access to several different state-of-the-art 3D microscopes as well as computers to visualize and process image data. The facility houses equipment for 2D or 3D imaging of fixed and living specimens. High Read More...
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Bioinformatics
06/18/2025 - Gene et enrichment analy i (G EA) i a popular tool for evaluating functional enrichment, e pecially following differential expre ion analy i . Thi e ion of the BTEP Coding Club will how attendee Read More...
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Bioinformatics
04/14/2025 - Gene set analysis (GSA) is essential in genomic research, yet traditional methods often lack transparency and produce contextually irrelevant results, making interpretation challenging. While large language models (LLMs) offer a promising solution for result Read More...
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Bioinformatics
06/12/2024 - For inquires send email to staff@hpc.nih.gov Next edition of the NIH HPC monthly Zoom-In Consults! All Biowulf users, and all those interested in using the systems, are invited to stop by Read More...
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Bioinformatics
{{Sdet}} Solution{{Esum}} ggplot ( iris ) + geom_point ( aes ( Petal.Length , Petal.Width , fill = Species ), size = 2 , shape = 21 ) + coord_fixed ( ratio = 1 , ylim = c ( 0 , 2.75 ), xlim = c ( 0 , 7 )) + scale_y_continuous ( breaks = c ( 0 , 0.5 , 1 , 1.5 , 2 , 2.5 )) + scale_x_continuous ( breaks = c ( 0 , 1 , 2 , 3 , 4 , 5 , 6 , 7 )) + scale_fill_ Read More...
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Bioinformatics
In order to create a ggplot2 bar plot we will need to reshape the data. The sample names should be in a single column named Sample and the gene counts in a single column named Read More...
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Bioinformatics
Note that we now have differential expression by transcripts and our first column contains the transcript IDs. But what genes do these transcripts map to? We will need to do some data wrangling to find Read More...
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Bioinformatics
The gene view lists disease(s) that the gene may play a role in.
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Bioinformatics
DAVID compares the overlap of user provided gene list to an annotation to the overlap of a background gene list to the same annotation. Thus, DAVID is really using the Fisher exact test to determine Read More...
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Bioinformatics
DAVID compares the overlap of user provided gene list to an annotation to the overlap of a background gene list to the same annotation. Thus, DAVID is using the Fisher exact test to determine if Read More...
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Bioinformatics
“Gene set enrichment analysis” refers to the process of discovering the common characteristics potentially present in a list of genes. When these characteristics are GO terms, the process is called “functional enrichment.” Warning Overall GO Read More...
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Bioinformatics
“Gene set enrichment analysis” refers to the process of discovering the common characteristics potentially present in a list of genes. When these characteristics are GO terms, the process is called “functional enrichment.” Warning Overall GO Read More...
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Bioinformatics
Many of the tools used to understand functional enrichment will use sets of GO terms, examining GO enrichment. What do we mean by GO? The Gene Ontology (GO) provides a framework and set of concepts Read More...
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Bioinformatics
{{Sdet}} Solution{{Esum}} ggplot ( iris ) + geom_point ( aes ( Petal.Length , Petal.Width , fill = Species ), size = 2 , shape = 21 ) + coord_fixed ( ratio = 1 , ylim = c ( 0 , 2.75 ), xlim = c ( 0 , 7 )) + scale_y_continuous ( breaks = c ( 0 , 0.5 , 1 , 1.5 , 2 , 2.5 )) + scale_x_continuous ( breaks = c ( 0 , 1 , 2 , 3 , 4 , 5 , 6 , 7 )) + scale_fill_ Read More...
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Bioinformatics
04/06/2022 - Gene set enrichment analysis (GSEA) is a statistical method that can be used to determine if gene sets are differentially expressed in different phenotypes. Qlucore Omics Explorer has implemented the GSEA method in a Read More...
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Bioinformatics
10/30/2012 - Due to the weather related shutdown of the FEDERAL GOVERNMENT (NIH) this seminar has been POSTPONED ... we will attempt to reschedule at a later date. (10-30-2012) Topics to be covered I. Genomic and Read More...
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Bioinformatics
Go back to /data/user/hcc1395_b4b. cd /data/user/hcc1395_b4b Create a directory called hcc1395_featurecounts. mkdir hcc1395_featurecounts Go back into /data/user/hcc1395_b4b/hcc1395_hisat2 for this Read More...
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Bioinformatics
The module featureCounts from the subread package will be used to quantify gene expression. In the featureCounts command below: -p: specifies the presence of paired end data. --countReadPairs: specifies to count both reads in a Read More...
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Bioinformatics
Participants can work on these practice questions on their own time as a Biowulf account or local installation of IGV is needed. Open the bigWig files for HBR_Rep1 (HBR_Rep1_hisat2.bw) and UHR_ Read More...
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Bioinformatics
The gene view lists the disease terms for each gene in the annotation category of interest. This is the Functional Annotation Table.
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Bioinformatics
Many of the tools used to understand functional enrichment will use sets of GO terms, examining GO enrichment. What do we mean by GO? The Gene Ontology (GO) provides a framework and set of concepts Read More...
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Bioinformatics
Definition "The goal of GSEA is to determine whether members of a gene set S tend to occur toward the top (or bottom) of the list L, in which case the gene set is Read More...
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Bioinformatics
The Functional Classification Tool provides a rapid means to organize large lists of genes into functionally related groups to help unravel the biological content captured by high throughput technologies. - DAVID documentation - Functional Classification Read More...
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Bioinformatics
04/09/2025 - Dr. Aristotelis Tsirigos will present a seminar titled "Investigating the role of 3D chromatin in gene regulation using data integration and machine learning" for the LRBGE Seminar Series.
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Bioinformatics
04/01/2025 - Whether you are measuring mRNA expression, protein expression, DNA methylation, expressed miRNAs, protein binding to DNA or RNA, etc., you will likely end up with a list of genes or gene products from which Read More...
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Bioinformatics
03/04/2025 - Alignment of RNA sequencing data enables researchers to identify where in the genome each sequence came from. However, it does not inform of how many sequences aligned to each genomic feature such as a Read More...
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Bioinformatics
02/24/2025 - AI Club is a weekly meeting that explores various topics relating to AI and deep learning in biomedical sciences, typically in a seminar, workshop, or journal club format. AI Club is intended to be Read More...
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Bioinformatics
07/19/2024 - The molecular mechanisms underlying many types of cancer involve aberrances in trans-acting factors and their binding to cis-regulatory elements to regulate gene expression. Techniques such as ChIP-seq, DNase-seq, and ATAC-seq are commonly used to Read More...
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Bioinformatics
01/03/2024 - on Wednesday, January 3rd at noon in Building 41, Conference Room C507/C509 and online. In-person attendance is encouraged. Dr. Larson's research is focused on understanding gene expression in eukaryotic Read More...
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Bioinformatics
Many of the packages that handle RNASeq count data do not work correctly with decimal numbers. We need to convert these numbers to integers using mutate() . Save your transformed data frame to an object named Read More...
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Bioinformatics
10/25/2023 - Every week, thousands of biomedical research papers are published with a portion of them containing supporting tables with data about genes, transcripts, variants, and proteins. For example, supporting tables may contain differentially expressed genes Read More...
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Bioinformatics
This page contains content taken directly from the Biostar Handbook by Istvan Albert. Always remember to start the bioinformatics environment. conda activate bioinfo We will be analyzing differential expression of genes on Chr22 from the Read More...
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Bioinformatics
This page contains content taken directly from the Biostar Handbook by Istvan Albert. Always remember to start the bioinformatics environment. conda activate bioinfo We will be analyzing differential expression of genes on Chr22 from the Read More...
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Bioinformatics
Lesson 12 Practice Objectives In this practice session, we will work with something new, which is a dataset from the Griffith lab RNA sequencing tutorial. Here, we will have a chance to practice what we have Read More...
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Bioinformatics
Why Learn Bioinformatics? Analyze your own data Expand scientific training and skills Provide a path to a new career Have a better understanding of how other people analyze data What is Unix? an operating system, Read More...
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Bioinformatics
Why Learn Bioinformatics? Analyze your own data Expand scientific training and skills Provide a path to a new career Have a better understanding of how other people analyze data What is Unix? an operating system, Read More...
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Bioinformatics
Why Learn Bioinformatics? Analyze your own data Expand scientific training and skills Provide a path to a new career Have a better understanding of how other people analyze data What is Unix? an operating system, Read More...
Web Page
Bioinformatics
Why Learn Bioinformatics? Analyze your own data Expand scientific training and skills Provide a path to a new career Have a better understanding of how other people analyze data What is Unix? an operating system, Read More...
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Bioinformatics
If we click on the blue bar next to the chart button, we will be taken to a gene view of the disease terms.
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Bioinformatics
Using the Gene Functional Classifier to group genes with similar annotations, how many clusters do we get? {{Sdet}} Solution{{Esum}} {{Edet}}
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Bioinformatics
Gene ontology and pathway analysis: PowerPoint slides
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Bioinformatics
Lessons focus on gene ontology and pathway analysis. Lesson 17: Introduction to gene ontology and pathway analysis ( Recording ) Lesson 18: Functional enrichment with DAVID ( Recording ) Lesson 19: Pathway analysis with Qiagen IPA ( Recording ) Lesson 20: Review and Course Wrap-up ( Read More...
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Bioinformatics
Differential expression and interpretation of results Brief introduction to gene ontology and pathway analysis
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Bioinformatics
Go under the Gene Ontology section in the Annotation Summary Results and expand on it. Click the chart view for GOTERM_BP_DIRECT to look at some biological processes that the upregulated genes in the Read More...
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Bioinformatics
Gene ontology and pathway analysis Objectives Determine potential next steps following differential expression analysis. Tour geneontology.org and understand the three main ontologies. Learn about different methods and tools related to functional enrichment and pathway Read More...
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Bioinformatics
Whether you are measuring mRNA expression, protein expression, DNA methylation, expressed miRNAs, protein binding to DNA or RNA, etc., you will likely end up with a list of genes or gene products from which you Read More...
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Bioinformatics
06/15/2023 - Since its release in September 2005, the Gene Set Enrichment Analysis (GSEA) software and its companion gene set collections, the Molecular Signatures Database (MSigDB), have been invaluable resources for interpreting the biological significance of expression Read More...
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Bioinformatics
05/18/2022 - Powerful and Intuitive Gene Expression Visualization Tools to Interpret Biological Signals – Bulk and Single Cell Data The increasing use of genomic technologies, such as RNA-Seq and single cell RNA-Seq, to assess gene expression patterns Read More...
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Bioinformatics
09/22/2021 - Registration is required. During this upcoming webinar, Dr. Yanjun Qi will demonstrate AttentiveChrome, an attention-based deep learning approach that uses a unified architecture to model and interpret interactions and dependencies among the chromatin factors Read More...
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Bioinformatics
07/15/2021 - Meeting Link: https://cbiit.webex.com/cbiit/j.php?MTID=m933690e1ccdbfd15ae3f75d1cbec3b95 TOPIC: AI in Molecular Data, presented by NVIDIA This talk will describe machine learning and deep Read More...
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Bioinformatics
07/15/2021 - Registration: https://btep.ccr.cancer.gov/classes/ai_three/ Meeting Link: https://cbiit.webex.com/cbiit/j.php?MTID=m933690e1ccdbfd15ae3f75d1cbec3b95 Description: This talk will describe machine learning Read More...
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Bioinformatics
06/02/2021 - Register Description: Over the last 15 years the Gene Set Enrichment Analysis (GSEA) software and its companion gene set collections, the Molecular Signatures Database (MSigDB) have served as key resources for interpreting the biological significance Read More...
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Bioinformatics
05/05/2021 - Register Session Description The Human Gene Mutation Database (HGMD) database provides quick access to known published gene lesions responsible for human inherited disease. This session will explore how to query genes and mutations in Read More...
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Bioinformatics
03/18/2021 - Recording Link CD8 T cell dysfunction is observed in diverse settings of chronic antigen exposure, including in cancer and chronic viral infection. We carried out a unified analysis of over 300 ATAC-seq and RNA-seq experiments Read More...
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Bioinformatics
10/07/2020 - QIAGEN’s Ingenuity Variant Analysis (IVA) combines analytical tools and integrated content to help you rapidly identify and prioritize variants by drilling down to a small, targeted subset of compelling variants based on published Read More...
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Bioinformatics
09/24/2020 - Over the last 15 years, since its release in September 2005, the Gene Set Enrichment Analysis (GSEA) software and its companion gene set collections, the Molecular Signatures Database (MSigDB) have served as key resources for interpreting Read More...
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Bioinformatics
06/15/2020 - This session will focus on NGS data, multi-omics analysis of array, and sequence data. Participants will work with text files in GeneSpring for NGS gene expression workflow and .vcf files for variant analysis.
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Bioinformatics
06/20/2014 - NCI CCR http://bioinformatics.nci.nih.gov/training/ and the NIH Library Bioinformatics Support Program http://nihlibrary.nih.gov/Bioinformatics are partnering to sponsor training on the use of NCBI GEO Datasets to analyze Read More...
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Bioinformatics
04/16/2013 - Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). Using gene sets, Read More...
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Bioinformatics
11/14/2012 - This is a repeat class for those who couldn't make it into the class on October 9th Learn the basics of microarray gene expression analysis using Partek Genomics Suite and Partek Pathway. As Read More...
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Bioinformatics
10/09/2012 - Learn the basics of microarray gene expression analysis using Partek Genomics Suite and Partek Pathway. As we walk though hands-on analysis of a cancer dataset, you will learn the principles of experimental design, batch Read More...
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Bioinformatics
If we click on the blue bar next to the chart button, we will be taken to a gene view of the disease terms.
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Bioinformatics
Normalization of gene expression estimates obtained from the quantification step is important as this will remove technical or non-biological variants in the data such as: Differences in sequencing depth between samples (ie. not all samples Read More...
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Bioinformatics
Gene expression table can be generated from the read alignment. Options for generating an expression table. Because there a GTF annotation file is avaialable, this exercise will use the Quantify to annotation model (Partek E/ Read More...
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Bioinformatics
import pandas import seaborn import matplotlib.pyplot as plt counts1=pandas.read_csv("./hbr_uhr_top_deg_normalized_counts.csv", index_col=[0]) seaborn.clustermap(counts1,z_score=0,cmap="viridis", figsize=(5,5)) plt. Read More...
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Bioinformatics
{{Sdet}}{{Ssum}}Gene expression by microarray{{Esum}} CLC Genomics Workbench What file types can I start my analysis with? Affymetrix Gene Chip (CHP, NetAFFx, CEL) Illumina BeadChip TSV CSV Partek Flow What file types can Read More...
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Bioinformatics
ls (list) pwd (print working directory) touch (creates an empty file) nano (basic editor for creating small text files) using the "rm" command to remove files. Be careful! mkdir (make a directory) and Read More...
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Bioinformatics
ls (list) pwd (print working directory) touch (creates an empty file) nano (basic editor for creating small text files) using the "rm" command to remove files. Be careful! mkdir (make a directory) and Read More...
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Bioinformatics
ls (list) pwd (print working directory) touch (creates an empty file) nano (basic editor for creating small text files) using the rm command to remove files. Be careful! mkdir (make a directory) and rmdir (remove Read More...
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Bioinformatics
ls (list) pwd (print working directory) touch (creates an empty file) nano (basic editor for creating small text files) using the rm command to remove files. Be careful! mkdir (make a directory) and rmdir (remove Read More...
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Bioinformatics
This page contains content directly from the Biostar Handbook by Istvan Albert. Always remember to activate your bioinformatics environment. conda activate bioinfo What is a sequence pattern? A sequence pattern is a sequence of bases Read More...
Frederick, Maryland
Core Facility
CLIA-Certified Technologies Offered: Fragment Analysis for Micro-satellite Instability Detection, Pharmacoscan Array for Pharmacogenomics, Mutation Detection for PCR and Sanger Sequencing, DNA extraction from whole blood, saliva, FFPE tissues, buccal swabs, nails, hair, PBMCs, buffy coats, Read More...
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Bioinformatics
09/11/2024 - Qlucore Omics Explorer is a point-and-click package available to NCI CCR scientists that enables visualization-based analysis of multi-omics data including RNA-seq, scRNA-seq, proteomics, metabolomics, as well as enabling the use of machine learning classification Read More...
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Bioinformatics
From the paper where this data was obtained, the following (incomplete) list of gene markers was obtained: Mmp3: preadipocytes Mki67: proliferating cells Fabp4: differentiating beige adipocytes and differentiated beige adipocytes Scd1: differentiated beige adipocytes Ucp1: Read More...
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Bioinformatics
Let's now create a gene expression heatmap for results generated using the classification based approach. We have our results.csv and design.csv file in our salmon directory so we just need to do Read More...
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Bioinformatics
“Gene set enrichment analysis” refers to the process of discovering the common characteristics potentially present in a list of genes. When these characteristics are GO terms, the process is called “functional enrichment.” Warning Overall GO Read More...
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Bioinformatics
01/27/2021 - Please plan to attend the Earl Stadtman Investigator Program search seminar by: Qian Zhu, Ph.D. Dana Farber Cancer Institute/Boston Children's Hospital Dr. Zhu's research interests include: single-cell genomics; spatial transcriptomics; Read More...
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Bioinformatics
11/17/2020 - Register The goal of this meeting is to critically address the wealth of new data generated by bulk and single-cell molecular, imaging and computational approaches that are increasingly revealing how the genome folds to Read More...
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Bioinformatics
11/16/2020 - Register The goal of this meeting is to critically address the wealth of new data generated by bulk and single-cell molecular, imaging and computational approaches that are increasingly revealing how the genome folds to Read More...
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Bioinformatics
02/20/2020 - Learn how to easily analyze your gene expression data yourself - using Qlucore Omics Explorer NCI/CCR:To get access to Qlucore, put a request into NCI at Your Service under Get Help https:// Read More...
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Bioinformatics
07/17/2019 - Learn how to get started on using QIAGEN’s Ingenuity Pathway Analysis (IPA) to quickly identify biological relationships, mechanisms, pathways, functions and diseases most relevant to experimental datasets. IPA is cited in >16,000 Read More...
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Bioinformatics
04/23/2013 - Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically significant, concordant differences between two biological states (e.g. phenotypes). The GSEA software Read More...
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Bioinformatics
10/02/2012 - Microarray Technology and Preprocessing Quality Control Normalization Using MAS5 and RMA Filtering Batch Effect Correction Basic Statistical Tests for Differentially Expressed Genes T-test ANOVA SAM Calculating False Discovery Rate Principal Components Analysis and Clustering Read More...
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Bioinformatics
03/24/2025 - AI Club is a weekly meeting that explores various topics relating to AI and deep learning in biomedical sciences, typically in a seminar, workshop, or journal club format. AI Club is intended to be Read More...
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Bioinformatics
Learn to align the sequencing reads to reference Familiarize ourselves with the content of alignment output files (SAM) Learn to use SAMTOOLS to work with alignment output
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Bioinformatics
11/21/2023 - Dear Colleagues, This presentation will provide an overview of OpenCRAVAT. Annotation and interpretation of cancer variants is critical to the design of personalized molecular therapies, and Read More...
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Bioinformatics
10/18/2023 - This October session of the BTEP Coding club will feature a tutorial on how to access data from GEO as well as how to submit data to GEO.
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Bioinformatics
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Bioinformatics
Discuss what this is Where can we find descriptors geneontology.org organism specific databases What is KEGG?
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Bioinformatics
Functional enrichment and pathway analysis have broad and varying definitions. For our purposes, there are three general approaches: 1. Over-Representation Analysis (ORA), 2. Functional Class Scoring (FCS), and 3. Pathway Topology (PT) ( Khatri et al. 2012 ). Examining genes in Read More...
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October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...
Frederick, MD
Collaborative
The Biopharmaceutical Development Program (BDP) provides resources for the development of investigational biological agents. The BDP supports feasibility through development and Phase I/II cGMP manufacturing plus regulatory documentation.The BDP was established in 1993. We Read More...
Frederick, MD
Core Facility
Repositories
The Mouse Modeling Core assists NIH investigators by generating and preserving genetically-engineered mouse strains. Services include scientific consultation, gene-targeting in mouse embryonic stem cells, micro-injection of nucleic acids, proteins, or ES cells into mouse embryos, Read More...
Frederick, MD
Collaborative
The primary objective of the Protein Technology Core (PTC) is to establish an experimental screening pipeline for single-domain antibodies termed nanobodies. Nanobodies are antibody fragments consisting of a single monomeric variable antibody domain. The PTC, Read More...
Bethesda, MD
Core Facility
Trans NIH Facility
The NHLBI Transgenic Core’s main mission is to keep up with the latest advancements in genome engineering technologies and to provide state-of-the-art services to assist NIH scientists in generating genetically engineered animal models. In Read More...
Frederick, MD
Core Facility
The Genomics Technology Laboratory is an integrated, high-throughput molecular biology laboratory focusing on the development of genetics and genomics technologies, data analysis, and information management tools, in support of CCR Investigators. The laboratory develops integrated Read More...
Bethesda, Maryland
Collaborative
Radiation Oncology Branch is part of CCR. Bioinformatics core is a collaborative resource to support ROB branch and provide service to ROB investigators from NCI and other Institutes access to new technologies, bioinformatics, statistical analysis Read More...
Bethesda, MD
Trans NIH Facility
The NIH Biowulf Cluster provides researchers with a world-class system to assist in solving complex biomedical problems as diverse as gene variation in worldwide human populations, deep learning to model protein structures, and PET brain Read More...
Rockville, MD
Repositories
Trans NIH Facility
Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status, and enzyme activity levels. You can choose to search for a Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. If you haven’t Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. We would greatly appreciate Read More...
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Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.
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The Genomics Laboratory (formerly Laboratory of Molecular Technology) is an integrated, high-throughput molecular biology laboratory focusing on the development of genetics and genomics technologies, together with associated laboratory automation systems, data analysis, and information management Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Advance your research with the NIH Mouse Imaging Facility (MIF) The NIH Mouse Imaging Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Derive Greater Insights and Accelerate your Research Using Bioinformatic Tools! CREx is an NIH Read More...
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Total end-to-end system for single-cell research [embed]https://youtu.be/vMzhSzg1rUw[/embed] The BD Rhapsody Single-Cell Analysis system empowers and streamlines your research with a complete system of tools, including reagents and analysis software, Read More...
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What is Xenium? Xenium is a high-resolution, imaging-based in situ spatial profiling technology from 10x Genomics that allows for simultaneous expression analysis of RNA targets (currently in range of 100’s) within the same tissue section. Read More...
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CREx News & Updates October 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGLIGHTS Learn more about services from the CPTR Read More...
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The CLIA Molecular Diagnostics Laboratory (CMDL) provides an array of services for groups at the NIH Clinical Center, Fort Detrick, and Hood College, among others. They support cancer- and disease-related research by making Read More...
Rockville, MD
Collaborative
We are a bioinformatics team within the Center for Biomedical Informatics and Information Technology’s (CBIIT’s) Cancer Informatics Branch (CIB)—soon to be referred to as the Informatics and Data Science (IDS) Program. Headed Read More...
Bethesda, MD
Core Facility
The CCR Genomics Core is located in Building 41 on the NIH Bethesda campus. The primary goal of the Core is to provide investigators from CCR/NCI and other NIH Institutes access to genomic technologies and Read More...
Frederick, MD
Core Facility
NCI LASP Genome Modification Core (GMC) is a CCR-dedicated facility that provides advice, training, and reagents to NCI scientists seeking to utilize CRISPR and other nucleases to generate genome modifications in primary cells, cell lines, Read More...
Bethesda, MD
Trans NIH Facility
The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured Read More...
Rockville, MD
Trans NIH Facility
NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to Read More...
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Our Mission The Office of Science and Technology Resources (OSTR) catalyzes the advancement of cancer research through making innovative technologies and scientific resources accessible to scientists at the Center for Cancer Research (CCR). OSTR develops Read More...
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OSTR offers two distinct supplemental funding mechanisms for CCR PI’s to request additional funds for technologies and research services requiring exceptional costs. Eligible expenses include services from Cores and outside vendors. A third program ( Read More...
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OSTR offers two distinct supplemental funding mechanisms for CCR PI’s to request additional funds for technologies and research services requiring exceptional costs. Eligible expenses include services from Cores and outside vendors. A third program ( Read More...
Bloomington, IN
Repositories
Trans NIH Facility
The Bloomington Drosophila Stock Center (BDSC) collects, maintains, and distributes genetically defined strains of Drosophila melanogaster for research and education. The BDSC supports a large, worldwide community of scientists using Drosophila as a model organism Read More...
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Protein Expression Laboratory The Protein Expression Laboratory develops, improves, and delivers protein-centric services. Our goal is to help client investigators achieve their research goals with the lowest possible cost in the shortest time. All PEL Read More...
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OSTR offers two distinct supplemental funding mechanisms for CCR PI’s to request additional funds for technologies and research services requiring exceptional costs. Eligible expenses include services from Cores and outside vendors. A third program ( Read More...
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CREx News & Updates July 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...
Bethesda, MD
Core Facility
Trans NIH Facility
The Center of Cellular Engineering (CCE) is a comprehensive facility that develops and manufactures a wide range of cell and gene therapies for early phase clinical trials. The CCE is currently manufacturing chimeric antigen receptor ( Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Spotlight The NIH Lab Managers Working Group have developed a new NIH-wide database of cold Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More. New Resources on CREx NIMH Human Brain Collection Core (HBCC) The HBCC obtains human brain tissue, hair, and blood Read More...
Rockville, MD
Core Facility
Trans NIH Facility
The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA Read More...
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[embed]https://youtu.be/yTl1Q0D7aZ0[/embed] 10x Genomics' supports multiple cancer research areas from single nucleotide and structural variant detection to single cell whole transcriptome gene expression analysis of thousands of individual Read More...
Bethesda, MD
Core Facility
The Genomics and Pharmacology Facility is part of the NCI's Center for Cancer Research (CCR), within the Developmental Therapeutics Branch. Its mission is to manage and assess molecular interaction data obtained through multiple platforms, increase Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx Program Manager The CREx Team is happy to announce Deepika Velampati as the new CREx Program Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Research Festival The NIH Research Festival highlights the groundbreaking science and the vibrant NIH community driving our Read More...
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Back Services: This instrument is not user accessible. We provide both data collection and data analysis services. Location: Building 50, room 3331 Description: An analytical ultracentrifuge is equipped with absorption and interference optical systems that monitor Read More...
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The OSTR offers cutting-edge technology platforms to the CCR scientific community through centralized facilities. The videos accessed through this page are designed to introduce the various scientific methodologies OSTR makes available through the cores on Read More...
Bethesda, MD
Trans NIH Facility
The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Interested in imaging large scale biological samples? Volume electron microscopy allows for Read More...
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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Technology Event Biophysical Methods for Protein Interactions Monday, May 15 – Friday, May 19, 2023 This workshop will review the strategies of Read More...
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CREx News & Updates July 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...
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CREx News & Updates November 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the NINDS Quantitative Magnetic Resonance Imaging Core. NINDS Read More...
Bethesda, MD
Trans NIH Facility
NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and Read More...
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CREx News & Updates June 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Visit here to learn about services from Read More...
Bethesda, MD
Collaborative
Repositories
The National Cancer Institute (NCI) is developing a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), patient-derived organoids (PDOrg), and in vitro patient-derived tumor cell cultures (PDCs) and cancer-associated fibroblasts (CAFs). These Read More...
Bethesda, MD
Core Facility
Trans NIH Facility
The PET Department, CC, functions as a core facility that supports basic, translational, and clinical research using PET. It is a vertically integrated facility, with resources to produce positron-emitting radionuclides, manufacture PET radiopharmaceuticals in a Read More...
Bethesda, MD
Core Facility
The CCR Building 41 Flow Cytometry Core is a full-service facility within the Center for Cancer Research that supports over 150 users representing 26 laboratories. The Core Facility provides instrument and software training, technical expertise, assay development, and Read More...
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CREx News & Updates January 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NCI ANTIBODY CHARACTERIZATION LABORATORY (ACL) The ACL specializes in rigorously validating antibodies for signaling and Read More...
Bethesda, MD
Repositories
Trans NIH Facility
The NCI Genomic Data Commons (GDC) was established by the NCI Center for Cancer Genomics (CCG) to support the receipt, harmonization, distribution, and analysis of genomic and clinical data from cancer research programs. The GDC Read More...
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CREx News & Updates February 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight ORS Division of Veterinary Resources (DVR) DVR is the central NIH lab animal support program Read More...
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CREx News & Updates April 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...
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CREx News & Updates March 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NIA Nonhuman Primate Core The NIA Nonhuman Primate Core supports multi-disciplinary translational aging projects for Read More...
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CREx News & Updates August 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NCATS Functional Genomics Laboratory (FGL) FGL is designed to help NIH Investigators use the latest Read More...
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CREx News & Updates December 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the STRIDES Initiative. VIEW STRIDES INITIATIVE NIH Cores Read More...
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CREx News & Updates May 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...
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Back Services: Biophysics Facility offers ITC calorimeters as open-access instruments. First-time users must complete a short training session before gaining access to the instrument reservation calendar. Training includes performing a test experiment and Read More...
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[tabby title="Home"] About NICE-NIH Intramural CryoEM Consortium NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of Read More...
Frederick, MD
Collaborative
In order to meet increasing demands from both NIH intramural and extramural communities for access to a small angle X-ray scattering (SAXS) resource, the Center for Cancer Research (CCR) under the leadership of Drs. Jeffrey Read More...
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Back Services: Biophysics Facility offers MST as an open-access instrument. First-time users must complete a short training session before gaining access to the instrument reservation calendar. Training includes the KD determination of a Read More...
Frederick, MD
Core Facility
The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at Read More...
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Back Services: We offer a limited sample processing service using standard SEC-MALS and FFF protocols. This service is intended for the occasional users of this system. Researchers who expect to use this instrument Read More...
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Back Services: We offer a limited sample processing service using standard SEC-MALS and FFF protocols. This service is intended for the occasional users of this system. Researchers who expect to use this instrument Read More...