The Center for Inherited Disease Research (CIDR)'s  mission is to support the genetics community by providing high-quality, cutting-edge genomics services and technologies in order to expand our understanding of disease and catalyze discoveries that translate to patient care.  All NIH CIDR Program studies are supported by data sharing assistance. GWAS and sequencing studies are additionally provided both data cleaning services. GWAS studies include imputation services.Established TechnologiesSNP Genotyping, Using Illumina Infinium chemistries and Affymetrix Axiom chemistry, investigators hav… [learn more]

The Department of Bioethics offers consultation, collaboration, and education to intramural researchers and extramural program officers. The members of the Department are available to:Consult with investigators on ethical questions or concerns related to the design and/or conduct of research, Analyze emerging issues in bioethics, Collaborate on research assessing a wide range of issues in bioethics, Conduct and collaborate on empirical research to relevant to important issues in research ethics or bioethics more generally, Provide education and training on bioethics, OfferingsConsultation on r… [learn more]

The Mouse Metabolic Phenotyping Center (MMPC)Live Program provides standardized, high quality, unique, and hard to find phenotyping services for mouse models of diabetes, obesity, and related metabolic disorders. Emerging as the next iteration of the MMPC Program (2001–2021), MMPCLive is an outwardly-facing consortium of service cores that offer investigators reduced-cost consultation and metabolic, physiologic, and behavioral phenotyping tests on live mice. Four MMPCLive Centers located at universities around the country perform complex and often unique procedures in vivo on a fee-for-servi… [learn more]

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA screens, informatics/pathway analysis and rigorous follow-up. Genome-wide siRNA screens for human and mice are available. Also routinely included in screens are miRNA mimic and inhibitor libraries. Resources Screening Libraries Ambion Silencer Select Human Genome-Wide siRNA library targeting ~22,000 genes with three ind… [learn more]

The facilities at AIM are available for use by the entire NIH intramural research community. While we welcome users with any size imaging project, AIM specializes in large, yearlong (or longer), collaborative research efforts with NIH labs – providing sample preparation, microscope operation and development, and data processing/analysis as needed. We take care of the imaging and processing so that you can focus on the biology. Established Technologies Microscope Description Spatial Resolu… [learn more]

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement, and analysis. BEPS is centrally located on the main NIH campus and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms. Established Technologies Electron Microscopy The Electron Microscopy Unit provides instrumentation, training, and services for: immuno electron microscopy, electron tomography, and specimen preparation, including cryo-techniques… [learn more]

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement, and analysis. BEPS is centrally located on the main NIH campus and provides expertise that spans technologies ranging in scale from near-atomic resolution to intact organisms. Established Technologies Electron Microscopy The Electron Microscopy Unit provides instrumentation, training, and services for: immuno electron microscopy, electron tomography, and specimen preparation, including cryo-techniques… [learn more]

The NIH Biowulf Cluster provides researchers with a world-class system to assist in solving complex biomedical problems as diverse as gene variation in worldwide human populations, deep learning to model protein structures, and PET brain scan processing to identify plaques associated with Alzheimer’s disease. The Biowulf cluster requires an HPC account and a justification describing the computational requirements of the proposed research project. Customer Benefits The Biowulf cluster comprises over 105,000 cores communicating over dedicated high-speed networks and utilizing shared file se… [learn more]

The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured program provides centralized and efficient management of projects in full collaboration with NIH investigators to better understand human immune function and pathophysiology. Our team works closely to plan and optimize experimental workflows tailored to each investigator’s specific research goals; execute highly sophisticated technological proce… [learn more]

The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured program provides centralized and efficient management of projects in full collaboration with NIH investigators to better understand human immune function and pathophysiology. Our team works closely to plan and optimize experimental workflows tailored to each investigator’s specific research goals; execute highly sophisticated technological proce… [learn more]

The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured program provides centralized and efficient management of projects in full collaboration with NIH investigators to better understand human immune function and pathophysiology. Our team works closely to plan and optimize experimental workflows tailored to each investigator’s specific research goals; execute highly sophisticated technological proce… [learn more]

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies CIPS can process most modern imaging modalities such as MR, CT, PET and Ultrasound in anatomical regions from the hand to the heart. The CIPS lab currently offers services in seven exam categories: IP Dynamic Enhancement Dynamic Enhancement MRI (DEMRI) is a type of MRI study in which intravenous contrast is administered to a p… [learn more]

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies CIPS can process most modern imaging modalities such as MR, CT, PET and Ultrasound in anatomical regions from the hand to the heart. The CIPS lab currently offers services in seven exam categories: IP Dynamic Enhancement Dynamic Enhancement MRI (DEMRI) is a type of MRI study in which intravenous contrast is administered to a p… [learn more]

The Department of Laboratory Medicine provides state-of-the-art laboratory testing in support of Clinical Center patient care and will serve as a center of excellence in research and training in laboratory medicine, particularly in areas which utilize the unique strengths of the National Institutes of Health. Goals We are committed to the following goals:, Respectful, compassionate, and high-quality patient care, High standards of clinical laboratory practice and efficiency, Optimal support of clinical research protocols, Excellence in applied and medical re… [learn more]

Radiology and Imaging Sciences provides imaging services for National Institutes of Health (NIH) Clinical Center patients participating in research protocols conducted by the various NIH institutes. Services include X-rays, fluoroscopy, ultrasound, magnetic resonance imaging (MRI) scans, computed tomography (CT) scans, and interventional radiology (special procedures). Radiology also conducts research studies of clinical imaging procedures and offers training in biomedical imaging research.Established Technologies Radiology Body Imaging (conventional … [learn more]

The Metabolic Clinical Research Unit (MCRU) opened in 2007 as a key component of the Strategic Plan for NIH Obesity Research . The NIDDK worked closely with the Clinical Center to design the Unit, which houses state-of-the-art facilities and equipment for a wide range of metabolic clinical research studies. The MCRU brings together experts in a wide range of fields including metabolism, endocrinology, nutrition, cardiovascular biology, gastroenterology, hepatology, genetics, and behavioral sciences. It supports protocols designed by researchers from across all NIH institutes investigating the … [learn more]

The Neurorehabilitation and Biomechanics Research Section (also referred to as the NAB LAB) is a multidisciplinary group of highly qualified scientists, clinical and technical staff, and trainees with diverse backgrounds including medical, physical therapy, neuroscience and biomedical engineering expertise. Clinical Services Clinical services include comprehensive physical and functional assessments by Certified Adult and Pediatric Physical Medicine and Rehabilitation Medicine physicians and our team of physical therapists. Based on this initial assessment additional evaluations may be rec… [learn more]

The NIH Clinical Center Pharmacy Department provides pharmaceutical care to inpatients and outpatients on NIH intramural research protocols at the NIH Clinical Center. The Clinical Center facility encompasses 200 inpatient beds, 93 day-hospital stations, and 15 clinics. Clinical Center pharmacy staff provide sophisticated research support to health care providers as well as clinical investigators. Pharmacists conduct and participate in research programs that enhance knowledge regarding investigational drugs and new uses of commercially available agents. The Pharmacy Department's Investigation… [learn more]

The PET Department, CC, functions as a core facility that supports basic, translational, and clinical research using PET. It is a vertically integrated facility, with resources to produce positron-emitting radionuclides, manufacture PET radiopharmaceuticals in a cGMP facility, and use them to image CC patients. Our staff includes cyclotron engineers, radiochemists, physicians, physicists, radiopharmacists, imaging technologists, and regulatory/quality assurance experts. Services provided include research PET/CT and PET/MR scans in humans under IRB-approved clinical research protocols and ship… [learn more]

The Center of Cellular Engineering (CCE) is a comprehensive facility that develops and manufactures a wide range of cell and gene therapies for early phase clinical trials. The CCE is currently manufacturing chimeric antigen receptor (CAR) T-cells, T-cell receptor (TCR)-engineered T-cells, cancer vaccines, induced pluripotent stem cells (iPSC), retinal pigmented epithelial cells derived from autologous iPSC and genetically modified hematopoietic stems cells. In the past the CCE has manufactured dendritic cells, NK cells, virus specific T-cells and mesenchymal stromal cells. The CCE also proces… [learn more]

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and infectious pathogens, using single particle or cryo-tomography approaches. Fine detailed 3D maps computed by electron micrographs spark numerous biological insights in cancer research, infectious disease research, vaccine design, cell development, and human physiological and functional studies. Mi… [learn more]

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to bring genomic sequence to biology and medicine. We accomplish this by meeting with each NIH investigator to discuss the details of their project to determine which method(s) would work best. The most common types of sequencing projects include whole exome sequencing, RNA sequencing, custom capture sequencing, CHiP-seq, and whole genome sequencing. However, we are always interested in … [learn more]

The NIH Metabolomics Consortium (NIH-MC) is a shared research resource that performs metabolomics analysis (and related small molecule research) for investigators at all Institutes and Centers across the NIH Intramural Research Program. The NIH-MC is administered at NIEHS with participating laboratories at NIEHS, NIA, and NIAID. The NIH-MC was established in 2023 and continues to grow in the offerings provided, expertise, and participatory labs. Established Technologies Metabolomics measures the small molecules – endogenous and exogenous – that underpin biological changes in response to … [learn more]

The Mouse Imaging Facility (MIF) is a shared, trans-NIH intramural resource for animal imaging studies. MIF provides access to state-of-the-art radiological imaging methods optimized for mice, rats, other animals, and tissue samples. MIF provides intellectual, technical, and material support for investigators using the MIF imaging facilities. The MIF is supported by all institutes at the NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, the MIF resides within NINDS and is physically located in the NIH MRI Research Center (NMRC) … [learn more]

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, NMRF resides within NINDS. The NMR Center Steering Committee provides the direct oversight for NMRF activities. Service Offerings Provide intellectual, technical and material support for investigators using its imaging and computer resources. , MRI using a state-of-the-art 7.0 T human MRI system and other resource… [learn more]

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Directors. Administratively, NMRF resides within NINDS. The NMR Center Steering Committee provides the direct oversight for NMRF activities. Service Offerings Provide intellectual, technical and material support for investigators using its imaging and computer resources. , MRI using a state-of-the-art 7.0 T human MRI system and other resource… [learn more]

The NIH Library is a biomedical research library, whose collection and services are available at no cost to NIH staff: Electronic Resources: Over 20,000 electronic journals, 190,000 eBooks, and 50 databases. , Training classes covering topics such as data science, systematic reviews, writing and publishing, and more., ServicesNIH Library services are supported by expert librarians and information specialists at no cost to NIH staff:3D Printing (digital modeling and printing), Bibliometrics (customized reports on publication metrics), Data Management & Analysis Support (consultations, trainin… [learn more]

In support of Intramural Research Program (IRP) scientists, DOHS provides training, consulting, and resources to ensure that laboratory equipment is used and maintained properly and safely. We provide expert safety and health consulting support for a variety of safety equipment and personal protective equipment (PPE). The primary means of laboratory safety include good laboratory practices and the use of containment equipment within the laboratory. Safety equipment includes biological safety cabinets (BSCs), chemical fume hoods (CFHs), PPE, and other controls designed to remove or minimize exp… [learn more]

In support of Intramural Research Program (IRP) scientists, DOHS provides training, consulting, and resources to ensure that workers' risk to hazards and stresses in the laboratory environment is minimized. Our services include one-on-one consultation with your IC Safety and Health Specialist, ergonomic assessments, pest management, risk assessments, and safety training. Our diverse services combined with our consulting capacity and innovative tools and approach give you the support to achieve a safe and healthful working environment. Services Biological safety compliance including bio… [learn more]

The Division of Veterinary Resources’ (DVR) mission is to contribute to the advancement of NIH biomedical research programs by providing excellence in animal care, customer service, and specialized research services to support intramural research efforts. DVR’s diverse and dedicated staff emphasizes accountability to the NIH researcher’s needs in areas including humane animal and veterinary care, animal behavior and enrichment, diagnostics and health surveillance, surgery, pharmacy, procurement, nutrition, and animal transportation. Established Technologies DVR professional staff i… [learn more]

The Division of Veterinary Resources Animal Surgery has supported large animal research and clinical care for more than 40 years. DVR surgeons provide outstanding and highly specialized large animal (rabbits, ungulates, etc.) research support in a state-of-the-art surgical suite. Specialty support includes surgical expertise, surgical and technical support, animal model development, and investigator training. We seek to support the unique needs and requirements of each investigator using animals in either basic or translational research. Established Technologies Facilities and Equipmen… [learn more]

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, mortality, or unexpected findings. In addition, mouse phenotyping and transmission electron microscopy services are available. Established Technologies The Pathology Service offers a Mouse Phenotyping Service with comprehensive pathologic analysis for genetically engineered mice. The Service provides standardized gross and histopathologic a… [learn more]

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, mortality, or unexpected findings. In addition, mouse phenotyping and transmission electron microscopy services are available. Established Technologies The Pathology Service offers a Mouse Phenotyping Service with comprehensive pathologic analysis for genetically engineered mice. The Service provides standardized gross and histopathologic a… [learn more]

The National Institutes of Health (NIH) Office of Research Services (ORS) Division of Radiation Safety (DRS) Radioactive Materials Control and Analysis Branch supports radioactive materials packaging/shipping. Established Technologies In accordance with Department of Transportation (DOT) requirements, all shipments of radioactive material including biological specimens must be packaged by an individual trained in DOT Hazmat requirements before they are offered for transport on public roads. DRS maintains a roster of DOT-trained individuals who can perform this packaging service and arrang… [learn more]

MAB provides visual communication solutions across all media to the entire NIH community. Our Medical Illustration section provides a complete range of biomedical visualization services, including manuscript/textbook figures, infographics, 3D modeling, animation, technical diagrams, and journal covers. MAB also offers a complete range of graphic design and production services. We are always here to help you with your scientific poster design and printing needs, including printing on cloth. List of Services Graphic Design Branding, Campaigns, Environmental graphics, E… [learn more]

The NIH Tetramer Core Facility (TCF) provides custom synthesis and distribution of soluble major histocompatibility complex (MHC)-peptide tetramer reagents that can be used to detect antigen-specific T cells. Approved investigators pay all shipping and handling costs for requested reagents and provide purified peptides for syntheses. [learn more]

The Science and Technology Research Infrastructure for Discovery, Experimentation, and Sustainability (STRIDES) Initiative The STRIDES Initiative aims to help NIH and its institutes, centers, and offices (ICOs) accelerate biomedical research by reducing barriers in utilizing commercial cloud services. This initiative aims to harness the power of the cloud to accelerate biomedical discovery. NIH and NIH-funded researchers can take advantage of STRIDES benefits. These key benefits include: Professional services—Access to professional service consultations and technical support from the S… [learn more]