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Search Results for: ELYRA Super Resolution Microscope

Total Results Found: 118

The CCR Microscopy Core
Bethesda, MARYLAND

Core Facility

The CCR Microscopy Core provides NCI investigators access to state-of-the-art imaging tools and techniques, including light sheet fluorescence, high-resolution confocal, multi-photon, and super-resolution microscopy. The mission of the CCR Microscopy Core Facility is to support Read More...

Instrumentation

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Confocal

ZEISS Elyra 7 with Lattice SIM² Type: Wide-field structured illumination microscope Capabilities: Super resolution 2D and 3D imaging of live or fixed cells Apotome SIM: 170 nm lateral, 450 nm axial Apotome SIM2: 140 nm lateral, 300 nm axial Lattice Read More...

Mapping Cancer Genetics at Single Cell Resolution

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Bioinformatics

08/28/2020 - Speaker: Dr. Luke Gilbert is an Assistant Professor in the Department of Urology, the Helen Diller Family Comprehensive Cancer Center and the Innovative Genomics Institute at the University of California, San Francisco. Dr. Gilbert Read More...

EIB Confocal Microscopy Facility
Bethesda, MD

Collaborative

As a multi-user facility, the different instruments provide a wide range of imaging modes for EIB scientists, from standard immunohistochemistry, through brightfield and wide-field epifluorescence imaging, to highly complex live cell confocal microscopy and super-resolution Read More...

CCR Optical Microscopy and Analysis Lab (OMAL)
Frederick, MD

Core Facility

OMAL focuses its research and development activities to quantitatively understand the molecular basis of three-dimensional (3D) cell organization, motility, invasion, and differentiation using fixed samples and live, 3D tissue culture models (i.e., translational models). Read More...

R Introductory Series: Coordinate systems

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Bioinformatics

ggplot2 uses a default coordinate system (the Cartesian coordinate system). This isn't super important until we want to do something like make a map (See coord_quickmap() ) or create a pie chart (See coord_ Read More...

R Introductory Series 2023: Coordinate systems

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Bioinformatics

ggplot2 uses a default coordinate system (the Cartesian coordinate system). This isn't super important until we want to do something like make a map (See coord_quickmap() ) or create a pie chart (See coord_ Read More...

ACD Spatial Genomics Seminar

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Bioinformatics

02/27/2020 - In this symposium, distinguished scientists will share recent successes in their research to visualize RNA targets at the single molecule level with single cell resolution and morphological context. Here are some of the exciting Read More...

March 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural CryoEM (NICE) Consortium NICE provides NCI, NIAID, NIEHS, NICHD, NIDCR, NEI, and NIA investigators with Read More...

April 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Extramural Common Fund Resources Metabolomics Workbench Developed by the NIH Metabolomics Common Fund's National Metabolomics Data Repository ( Read More...

NIH Intramural CryoEM Consortium (NICE)
Bethesda, MD

Trans NIH Facility

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and Read More...

Data Visualization in ggplot

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Bioinformatics

09/17/2024 - This hour and half online training will explore the topics of perception and cognition, and how these apply to data visualization. This class will also teach you how to visualize your data using ggplot2. Read More...

Microbiome Analysis with QIIME2: Denoising

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Bioinformatics

The field has moved to denoising sequences rather than OTU clustering. In a denoising approach, the exact biological sequence is inferred and noise is removed from the dataset via error correction. This is generally done Read More...

BTEP Lessons: Why ggplot2?

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Bioinformatics

Widespread popularity. Used to create informative plots quickly. Used to create high resolution plots. Used to customize many package specific plots. Over 100 related extensions Outside of base R plotting, one of the most popular packages Read More...

BTEP Lessons: Why ggplot2?

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Bioinformatics

Widespread popularity. Used to create informative plots quickly. Used to create high resolution plots. Used to customize many package specific plots. Over 100 related extensions ::: {.notes} Outside of base R plotting, one of the most popular Read More...

NCI Center for Structural Biology: Crystallization Facility
Frederick, MD

Collaborative

The Crystallization Facility provides an automated environment for setting up crystallization experiments in a high-throughput format, storing the resulting plates under controlled conditions, and monitoring the status of prepared droplets remotely. The Facility is in Read More...

Electron Microscopy

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Electron Microscopy Laboratory (EML) The EML offers investigators access to unique expertise and EM technologies that allow our partners to explore new avenues of research to enhance the knowledge of biological systems. To assist our Read More...

NICE-NIH Intramural CryoEM Consortium

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[tabby title="Home"] About NICE-NIH Intramural CryoEM Consortium  NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of Read More...

NCI High-Throughput Imaging Facility (HiTIF)
Bethesda, MD

Collaborative

The NCI High-Throughput Imaging Facility (HiTIF) works in a collaborative fashion with NCI/NIH Investigators by providing them with the necessary expertise, instrumentation, and software to develop and execute advanced High-Throughput Imaging (HTI) assays. These Read More...

Spatial Biology

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Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.

Spatial Biology

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Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.

CCR Spatial Imaging Technology Resource (SpITR)
Bethesda, MD

Collaborative

The Spatial Imaging Technology Resource (formerly the Nanoscale Protein Analysis Section of the Collaborative Protein Technology Resource or CPTR) provides expertise and service in state-of-the-art protein analysis technologies to advance CCR research in basic discovery Read More...

Software & Techniques

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Confocal

Software Image Acquisition Commercial imaging systems of LRBGE Optical Microscopy Core are controlled by acquisition software specifically designed for the appropriate microscope, such as ZEN (Zeiss confocal microscopes), Nikon Elements (Nikon), Imspector (Abberior). Custom-built HILO Read More...

Instrumentation

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Confocal

WIDE-FIELD MICROSCOPY Nikon Ti 2000 wide-field microscope Capabilities: This microscope is suited for live cell imaging (4D) and fixed cells (3D) imaging. This microscope produces high quality wide-field images that may be improved by Read More...

Data Visualization in ggplot: Customizations

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Bioinformatics

07/25/2024 - This hour and half in-person training will explore the topics of perception and cognition, and how these apply to data visualization. There will also be a discussion on “pre-attentive” properties Read More...

Data Visualization in ggplot

Web Page

Bioinformatics

07/24/2024 - This hour and half in-person training will explore the topics of perception and cognition, and how these apply to data visualization. There will also be a discussion on “pre-attentive” properties Read More...

Next-Generation Clustered Heat Maps

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Bioinformatics

06/20/2024 - Clustered heat maps are widely used for visualizing patterns in molecular profiling data. But traditional, static heat maps have significant limitations when applied to large datasets (1000s of elements per axis). Presented in this Read More...

Microbiome Analysis with QIIME2: Phylogeny

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Bioinformatics

In addition to clasifying our organisms, we also want to reconstruct their phylogenetic relationships by generating a phylogenetic tree. We often assume that phylogenetic closeness can elucidate commonalities in phenotypic properties / functions, so it is Read More...

Data Visualization with R: Saving a non-ggplot

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Bioinformatics

Recall that we can use the ggsave command to save a ggplot. However, heatmaps generated using the pheatmap package are not ggplots, therefore we need to turn to either the image export feature (Figure 7) in Read More...

Data Visualization with R: Saving a non-ggplot

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Bioinformatics

Recall that we can use the ggsave command to save a ggplot. However, heatmaps generated using the pheatmap package are not ggplots, therefore we need to turn to either the image export feature (Figure 7) in Read More...

Data Visualization with R: R Course FAQs

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Bioinformatics

Where can I find examples of different types of plots? The R Graph Gallery is a fantastic resource for R data visualization. The gallery can be used to explore different plot types and the code Read More...

Data Visualization with R: R Course FAQs

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Bioinformatics

R Course FAQs Where can I find examples of different types of plots? The R Graph Gallery is a fantastic resource for R data visualization. The gallery can be used to explore different plot types Read More...

Illumina seminar: DNA Methylation NGS and Microarrays

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Bioinformatics

06/29/2022 - The CCR Genomics, Sequencing and Single Cell Analysis Core Facilities are pleased to host a virtual technology seminar with Illumina. Presentation overview : For decades cancer methylation studies have provided insights into tumorigenic pathways and Read More...

The Brain Image Library: A Resource for Sharing Microscopy Data

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Bioinformatics

11/19/2021 - High-resolution, whole-brain microscopy provides unprecedented new insights into the brain’s structural organization, molecular diversity and connectivity. The Brain Image Library (BIL) provides infrastructure that facilitates the sharing of this valuable data, enabling investigators Read More...

Dissecting glioma biology by single-cell genomics

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Bioinformatics

06/16/2021 - Please mark your calendar for the next Neuro-Oncology Branch Visiting Scholar Lecture Series: CNS Malignancies: From Basic Biology to Clinical Applications . We are pleased to have Prof. Mario L. Suva,  join us via WebEx Read More...

Human Immune Monitoring Comes of Age

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Bioinformatics

09/10/2020 - Speaker: Shai Shen-Orr, Ph.D., Associate Professor, Israel Institute of Technology Registration Recent technological advances allow us to probe the immune system at high resolution and explore its variation between individuals. Yet the question Read More...

Introduction to Galaxy-P multi-omics

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Bioinformatics

06/28/2020 - The overarching goal of our work is to implement data analysis and informatics tools for integration of biological mass spectrometry data (proteomics and metabolomics) with genomic / transcriptomic information to advance cancer research. We are Read More...

QIAGEN Ingenuity Pathway Analysis (QIAGEN IPA)

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QIAGEN  Ingenuity Pathway Analysis (IPA) works with differential expression data (NGS, microarray, proteomics, and others) or genetic variant data to extract various biological insights. QIAGEN Ingenuity Pathway Analysis (IPA) High Impact Features and Functionality in Read More...

Xenium Spatial Profiling Technology

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What is Xenium? Xenium is a high-resolution, imaging-based in situ spatial profiling technology from 10x Genomics that allows for simultaneous expression analysis of RNA targets (currently in range of 100’s) within the same tissue section. Read More...

CCR Volume Electron Microscopy (CVEM)
Frederick, MD

Collaborative

CCR VOLUME Electron Microscopy (CVEM) aims to develop new techniques in volume electron microscopy (vEM) and, in collaboration with CCR Investigators, apply these techniques to research cell biological questions well-suited for study by high-resolution 3D Read More...

NIBIB Biomedical Engineering and Physical Science (BEPS)
Bethesda, MD

Trans NIH Facility

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement, and analysis. BEPS is centrally located on the main NIH campus Read More...

Center for Structural Biology: Biophysics Resource
Frederick, MD

Core Facility

The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The Read More...

January 2023 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx NIH NeuroBioBank (NBB) The NBB provides researchers with access to human post-mortem brain tissue Read More...

NCI Genetics Branch: OMICS Technology Facility
Bethesda, MD

Collaborative

Our operational objectives are to provide state-of-the-art OMICS technologies in support of the Genetics Branch (GB) investigators and collaborators. Research Services Wet Lab Single cell isolation from fresh, frozen, and FFPE tissue, DNA/RNA extractions Read More...

April 2023 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Interested in imaging large scale biological samples?  Volume electron microscopy allows for Read More...

May 2023 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Technology Event Biophysical Methods for Protein Interactions Monday, May 15 – Friday, May 19, 2023 This workshop will review the strategies of Read More...

NCATS Functional Genomics Laboratory
Rockville, MD

Core Facility

Trans NIH Facility

The Functional Genomics Laboratory (formerly, the RNAi Screening Facility) of the National Center for Advancing Translational Sciences (NCATS) assist investigators with all stages of project planning and execution, beginning with assay development through genome-wide siRNA Read More...

July 2023 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Cores on CREx NIBIB BEPS Micro Analytical Immunochemistry Unit The Micro Analytical Immunochemistry Unit employs a variety Read More...

July 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. We would greatly appreciate Read More...

NIH Mouse Imaging Facility (MIF)
Bethesda, MD

Trans NIH Facility

The Mouse Imaging Facility (MIF) is a shared, trans-NIH intramural resource for animal imaging studies. MIF provides access to state-of-the-art radiological imaging methods optimized for mice, rats, other animals, and tissue samples. MIF provides intellectual, Read More...

August 2024 Newsletter

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CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. If you haven’t Read More...

CCR Sequencing Facility
Frederick, MD

Core Facility

The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at Read More...

Visium Spatial Gene Expression Technology

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What is Visium FFPE v2 with CytAssist? Visium FFPE v2 is sequencing-based spatial profiling technology developed by 10x Genomics. This assay can take mouse or human tissue sections on normal glass slides as input and Read More...

July 2021

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CREx News & Updates July 2021   Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...

Mass Photometer (MP) – Refeyn OneMP

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Back Services: Biophysics Facility offers MP as an open-access instrument.  First-time users must complete a short training session before gaining access to the instrument training calendar.  Training includes mass distribution analysis of a Read More...

Fluorescence – PTI/Horiba QuantaMaster

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Back Services: Biophysics Facility offers fluorometers as open-access instruments.  First-time users must complete a short training session before gaining access to the instrument reservation calendar. Location: Building 50, room 3226 Description: Some substances reemit light after Read More...

Protein Characterization Laboratory

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Protein Characterization Laboratory (PCL) offers various technologies to CCR investigators to characterize proteins and metabolites. The laboratory develops and applies state-of-the-art analytical technologies, primarily mass spectrometry, liquid chromatography, and Surface Plasmon Resonance (SPR), to advance Read More...

Pan-Microbial Serology Facility (PMSF)
Bethesda, MD

Collaborative

The Pan-Microbial Serology Facility (PMSF) is part of the Center for Cancer Research (CCR) at the National Cancer Institute (NCI). The PMSF focuses on determining individualized pan-microbial immune profiles associated with human diseases including immunological Read More...

Multi-Angle Light Scattering (MALS)

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Back Services: We offer a limited sample processing service using standard SEC-MALS and FFF protocols.  This service is intended for the occasional users of this system.  Researchers who expect to use this instrument Read More...

Technology Video Library

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The OSTR offers cutting-edge technology platforms to the CCR scientific community through centralized facilities. The videos accessed through this page are designed to introduce the various scientific methodologies OSTR makes available through the cores on Read More...

BTEP Video Archive of Past Classes

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Bioinformatics

Listed below are the video recordings of past BTEP events (classes, seminars, workshops). Videos are hosted on various servers and may play slightly differently. Some videos may be downloaded for local viewing. Recorded Videos of Read More...

Microbiome Analysis with QIIME2: Beta Diversity

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Bioinformatics

Lesson 6 . Learning Objectives Introduce several beta diversity metrics Discover different ordination methods Learn about statistical methods that are applicable Beta diversity Beta diversity is between sample diversity. This is useful for answering the question, how Read More...

Microbiome Analysis with QIIME2: Metadata and importing

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Bioinformatics

Lesson 2: Getting Started with QIIME2 Lesson Objectives Obtain sequence data and sample metadata Import data and metadata Discuss other useful QIIME2 features including view QIIME2, provenance tracking, and the QIIME2 forum. DNAnexus DNAnexus provides a Read More...

Data Visualization with R: Lesson5

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Bioinformatics

Visualizing clusters with heatmaps Objectives Introduce the heatmap and dendrogram as tools for visualizing clusters in data. Learn how to work with the package pheatmap . Learn how to save a non-ggplot2 plot. Introduce ggplotify to Read More...

R Introductory Series 2023: ggplot2 Continued

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Bioinformatics

Objectives Review the grammar of graphics template. Learn about the statistical transformations inherent to geoms. Learn more about fine tuning figures with labels, legends, scales, and themes. Learn how to save plots with ggsave() . Review Read More...

TCGA Data Analysis Workshop (2-day)

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Bioinformatics

01/07/2016 - REGISTRATION IS FULL FOR THIS WORKSHOP (25 ATTENDEES; 6 WAITLIST) The Cancer Genome Atlas (TCGA) is a large-scale study that has cataloged genomic data accumulated for many different types of cancers, and includes mutations, copy number Read More...