Search Results for: computational chemistry

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“Metabolomics Research in the Intramural Research Program via the Trans-NIH Metabolomics Core and NIEHS Metabolomics Core Facility” Alan K. Jarmusch, Ph.D., Director, Metabolomics Core Facility Core, NIEHS. “Shared Chemistries of Disease: Hypothesis-driven metabolomic and Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Spotlight The NIH Lab Managers Working Group have developed a new NIH-wide database of cold Read More...

The research conducted within the Synthetic Biologics Core (SBC) Facility has a dual role: Generate chemical biology tools and drug candidates for molecular targets identified by NCI research groups, Develop novel effective methods and tools Read More...

The Cancer and Inflammation Program – Microbiome and Genetics Core (CIP-MGC) grew out of the former CIP Genetics Core to meet the increasing need for sequencing and analysis of commensal microbiota within CIP and NCI. The Read More...

The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The Read More...

September 8, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

The Department of Laboratory Medicine provides state-of-the-art laboratory testing in support of Clinical Center patient care and will serve as a center of excellence in research and training in laboratory medicine, particularly in areas which Read More...

The FNLCR Molecular Histopathology Laboratory (MHL) provides comprehensive veterinary pathology support for animal health monitoring, biomarker discovery and validation, drug development, genomics, and proteomics on a cost recovered basis. The MHL is organized into multiple Read More...

October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

The Center for Inherited Disease Research (CIDR)'s  mission is to support the genetics community by providing high-quality, cutting-edge genomics services and technologies in order to expand our understanding of disease and catalyze discoveries that Read More...

DTP maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. The Repository collection is a uniquely diverse set of more than 200,000 compounds that have been Read More...

The CCR Molecular Modeling Core, under the direction of Dr. Stewart Durell, was established to provide a convenient way for experimentalists to take advantage of molecular modeling and computational biology. In the framework of consultations, Read More...

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and Read More...

Cores & Facilities From centralized laboratories to collaborative resources and technologies available to CCR Investigators. NCI Cores Centralized laboratories providing broad access to cutting-edge technologies and specialized expertise. Browse NCI Cores Collaborative Resources are technologies and Read More...

The NCI Cloud Resources are components of the NCI Cancer Research Data Commons (CRDC) that bring data and computational power together to enable cancer research and discovery. These cloud-based platforms eliminate the need for researchers Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx Program Manager The CREx Team is happy to announce Deepika Velampati as the new CREx Program Read More...

The Mass Spectrometry Unit of the Collaborative Protein Technology Resource uses mass spectrometry for the study of proteins. We perform collaborative experiments with CCR researchers in areas such as: interactomes, quantitative global proteome analyses, and Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural Core Resources NHGRI Flow Cytometry Core The Core performs high quality single cell analysis through the Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. We would greatly appreciate Read More...

The OSTR offers cutting-edge technology platforms to the CCR scientific community through centralized facilities. The videos accessed through this page are designed to introduce the various scientific methodologies OSTR makes available through the cores on Read More...

What is Xenium? Xenium is a high-resolution, imaging-based in situ spatial profiling technology from 10x Genomics that allows for simultaneous expression analysis of RNA targets (currently in range of 100’s) within the same tissue section. Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Interested in imaging large scale biological samples?  Volume electron microscopy allows for Read More...

The NIH Center for Human Immunology, Inflammation, and Autoimmunity (CHI) is a trans-NIH resource whose mission is to provide a collaborative hub of advanced translational immunology for NIH clinical and pre-clinical studies. This uniquely structured Read More...

CREx News & Updates August 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NCATS Functional Genomics Laboratory (FGL) FGL is designed to help NIH Investigators use the latest Read More...

The Biophysics Core’s mission is to provide support in the study of macromolecular interactions, dynamics, and stability by offering consultations, training, professional collaborations, and instrument access. General Services Multi-technique molecular interaction studies, Kinetic and Read More...

CCR VOLUME Electron Microscopy Core (CVEMC),  formerly known as volume Electron Microscopy (vEM), aims to develop new techniques in volume electron microscopy (vEM) and, in collaboration with CCR Investigators, apply these techniques to research cell Read More...

Proteomic Data Common (PDC) represents the NCI’s largest public repository of proteogenomic comprehensive tumor datasets, essentially a Proteogenomic Cancer Atlas. It was developed to advance our understanding of how proteins help shape the risk, Read More...

CREx News & Updates August 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...

The CCR Genomics Core is located in Building 41 on the NIH Bethesda campus. The primary goal of the Core is to provide investigators from CCR/NCI and other NIH Institutes access to genomic technologies and Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Derive Greater Insights and Accelerate your Research Using Bioinformatic Tools! CREx is an NIH Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Advance your research with the NIH Mouse Imaging Facility (MIF) The NIH Mouse Imaging Read More...

CREx News & Updates September 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGLIGHTS Learn more about services from the CCR Read More...

The NCI Genomic Data Commons (GDC) was established by the NCI Center for Cancer Genomics (CCG) to support the receipt, harmonization, distribution, and analysis of genomic and clinical data from cancer research programs. The GDC Read More...

CREx News & Updates November 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the NINDS Quantitative Magnetic Resonance Imaging Core. NINDS Read More...

In order to meet increasing demands from both NIH intramural and extramural communities for access to a small angle X-ray scattering (SAXS) resource, the Center for Cancer Research (CCR) under the leadership of Drs. Jeffrey Read More...

11/26/2024 - This talk will introduce quantum chemistry and how it is useful for the modeling of therapeutic and diagnostic agents. This session is geared towards beginners. This session will be recorded, and materials will be Read More...

09/30/2022 - The goal of this webinar series is to enhance understanding within the NCI and the research community of opportunities for targeting fusion oncoproteins through emerging chemoproteomic methods. This presentation will focus on computational tools Read More...

02/12/2026 - The NLM Division of Intramural Research (DIR) is pleased to welcome Tiarnán Keenan, MD, PhD, Stadtman Tenure-Track Investigator and Director of the Medical Retina Fellowship Program at the National Eye Institute Read More...

The Advanced Biomedical Computational Science (ABCS) group focuses on applications of bioinformatics, computational and data science, and artificial intelligence to support NCI researchers. ABCS provides: • Subject matter expertise in genomics, proteomics, and imaging. • Machine learning/ Read More...

The Advanced Biomedical Computational Science (ABCS) group focuses on applications of bioinformatics, computational and data science, and artificial intelligence to support NCI researchers. ABCS provides: Subject matter expertise in genomics, proteomics, and imaging. Machine learning/ Read More...

In this session of the BTEP Coding Club, Titli Sarkar, PhD, Computational Scientist within the Advanced Biomedical Computational Science's Computational Chemistry and Protein Modeling Group (ABCS-CCPM), introduced scikit-learn, a free and open-source Python library Read More...

In this session of the BTEP Coding Club, Titli Sarkar, PhD, Computational Scientist within the Advanced Biomedical Computational Science's Computational Chemistry and Protein Modeling Group (ABCS-CCPM), discussed the art of choosing the best machine Read More...

05/22/2025 - It took over $3 billion and 13 years to sequence the first human genome. Today, we can sequence a genome in a single day for less than $1,000.  That incredible technological advancement has led to the generation Read More...

04/09/2025 - Game Changers in Computational Drug Discovery

03/26/2025 - Developing artificial intelligence (AI) schemes to assist the clinician towards enabling precision medicine approaches requires development of objective markers that are predictive of disease response to treatment or prognostic of longer-term patient survival. The Read More...

12/04/2024 - Galaxy is a web-based computational workbench for analyzing and visualizing biomedical datasets that is used by thousands of scientists daily.   Galaxy enables accessible, reproducible, and scalable biomedical data science by any scientist Read More...

Regarding computational requirements, rule of thumb is to keep it at 8 samples or less when running on a laptop. You may be able to stretch it to 10 samples, but any more than that strains the Read More...

03/26/2024 - In this session, we will discuss the potential of GPUs, and when and why to use GPUs on the Frederick Research Computing Environment (FRCE). We will explore the possibilities of GPU-accelerated AI applications and Read More...

11/07/2024 - In the era of renewed space exploration, understanding female health risks during spaceflight is essential. This talk focuses on leveraging NIAID's ImmPort and NASA's GeneLab data using computational and systems biology to Read More...

10/24/2024 - NIH Text Mining and Natural Language Processing SIG is pleased to welcome you to this special event featuring two extraordinary speakers focused on the applications of Deep Learning in Computational Biology.  & Read More...

04/11/2024 - Informaticians aim to bring the right information to the forefront at the right time to improve decision-making. Dr. Greene's  lab develops computational methods that integrate distinct large-scale datasets to extract the rich and Read More...

07/08/2025 - Join Dr . Eytan Ruppin (pre enter) and Timothy haw (moderator) a they pre ent on four approache for predicting how patient re pond to checkpoint immunotherapy. Approach #1: Predicting patient re pon e to the Read More...

07/07/2025 - Dr. Theodore Alexandrov lead a multidi ciplinary team of cienti t and oftware engineer dedicated to developing cutting-edge technologie for patial and ingle-cell metabolomic (http ://ateam.uc d.edu). They have developed META PACE, Read More...

08/29/2024 - Dr. Mardis is an internationally recognized expert in cancer genomics, with ongoing interests in the integrated characterization of cancer genomes, defining DNA-based somatic and germline interactions and RNA-based pathways, and immune microenvironments that lead Read More...

Our Team Tatiana S. Karpova Ph.D.Core Headkarpovat@nih.govBuilding 41, Room C615240-760-6637 David A. Ball Ph.D.Core Biologistballa@nih.govBuilding 41, Room B114D240-760-6577 Mohamadreza Fazel, Ph.D.Core Biologistmohamadreza. Read More...

The computational chemistry and protein modeling team in the Advanced Biomedical Computational Science (ABCS) group provides novel solutions in structural modeling and computational chemistry. Computational scientists in the group collaborate with NCI researchers by using Read More...

02/11/2022 - The seminar is open to the public and registration is required each month. Dr. Hunter Mosely plans to discuss the richness of open data resources in biology and how they can support machine learning Read More...

01/07/2021 - Presenter: Gary Patti, Ph.D. Departments of Chemistry, Genetics, and Medicine Washington University in St. Louis It is well established that the metabolism of cancer cells is reprogrammed to support the demands of rapid Read More...

06/16/2020 - The capability to unambiguously and comprehensively identify thousands of metabolites and other chemicals in clinical samples, including the microbiome, will revolutionize the search for environmental, dietary, and metabolic determinants of health and disease. By Read More...

09/12/2024 - Dr. Nussinov will highlight some scientific questions bordering on physics and biology, where fundamental physics and chemistry can help biology. They span the behavior of a bird, protein activation, signaling in cancer, and neurodevelopmental Read More...

2024 Coutinho, L. L., Femino, E. L., Gonzalez, A. L., Moffat, R. L., Heinz, W. F., Cheng, R. Y. S., Lockett, S. J., Rangel, M. C., Ridnour, L. A. & Wink, D. A. NOS2 and Read More...

01/28/2026 - Learn about Data Science from Dr. Mark Jensen, Director of Data Science, Center for Operations and Technical Support (CTOS), Bioinformatics and Computational Science (BACS), Leidos Biomedical Research, Inc.

12/16/2025 - Abstract: Spatial transcriptomics (ST) is evolving rapidly as a pivotal technology in studying the biology of tumors and their associated tumor microenvironments (TME). However, where/how it can impact research remain unclear. In this Read More...

12/02/2025 - If you are looking for computational tools for your cancer research, join us for this upcoming training session on Galaxy, an open-source and browser-based computational platform. Dr. Jeremy Goecks, an NCI grantee and Assistant Read More...

07/09/2025 - From image analy i to federated learning and multimodal modeling, generative AI can be u ed to tudy ob ervational ucce ion acro cale and data type . At DCEG' Data cience and Engineering Re Read More...

03/27/2025 - Please note: Registration is required to get the Meeting Link for this event. Please pre-register. Aviv Regev is head of Genentech Research and Early Development. Formerly, Regev was Chair of the Faculty and Core Read More...

Bioinformatics support to CCR investigators is provided by: CCR Collaborative Bioinformatics Resource (CCBR) The CCR Collaborative Bioinformatics Resource (CCBR) is a resource group which provides a mechanism for CCR researchers to obtain many different types Read More...

The total number of detected transcripts expressed in a cell is dependent on the amount of mRNA in a cell. Cells naturally vary in the total amount of mRNA expressed. However, the chemistry of the Read More...

Who can you contact with questions? NCI CCR Single Cell Analysis Facility (SCAF) provides single cell support to NCI-CCR Researchers. NCI CCR Bioinformatics Training and Education Program (BTEP) provides bioinformatics training support. Contact BTEP via Read More...

Additional Resources BTEP scRNA-Seq FAQs Training modules available on Github Orchestrating Single Cell Analysis with Bioconductor Single Cell Best Practices 2023 BTEP Single Cell Annotation Seminar Series Event recordings are located in the BTEP Video Archive . Read More...

05/28/2024 - Frederick Research Computing Environment (FRCE) and Computational Sciences Series In this session, we will explore how machine learning can be used to analyze whole slide pathological images (WSIs). We will showcase how to utilize Read More...

05/15/2024 - To register to attend, you must log in to your SITC Cancer Immunotherapy CONNECT account. Don’t have an account?  Create a free one . Join Dr. Karchin of the Johns Read More...

04/23/2024 - Crunching of large data requires large resources. Exploration of holobiont metagenomes is considered a “big data” project and here I’ll be describing how I used the FRCE Read More...

03/29/2024 - This event is sponsored by an organization outside of the NIH; it is listed here due to the nature of the presented topics and their appeal to the NCI community. Description: Recent developments in Read More...

No summary available.

Gianluca Pegoraro, PhD gianluca.pegoraro@nih.gov Facility Head 240-760-6696 Bldg. 41, Room B909 Dr. Pegoraro received his Ph.D. in Molecular Genetics from the International School of Superior Studies in Trieste, Italy in 2004. After Read More...

2024 Date: Tuesday, October 15, 2024 Time and Location: 11 am EST, ZOOM (INVITATION BY LMIG LIST SERVER) Speaker: Dr. Diego Presman (U Buenos Aires) Title: “Insights on Glucocorticoid Receptor Activity Through Live Cell Imaging” Summary: Eucaryotic transcription factors ( Read More...

03/19/2026 - In this talk, Dr. Carey will describe how Bioconductor approaches new challenges in supporting open method development and reproducible analyses in genomic data science. He will discuss aspects of the project that bear on Read More...

02/12/2026 - Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Dr. Baker’s goal is to design a new generation of proteins that Read More...

01/14/2026 - During this event, Dr. Emilie Roncali, an associate professor at UC Davis, is tackling an intersection of two critical data science concepts in cancer research: theranostics and digital twins. Dr. Roncali will give you Read More...

12/11/2025 - If you’re interested in learning how machine learning can help you tap into the rich data within electronic health records, join us to learn more about the “Memorial Sloan Read More...

10/09/2025 - This one-hour online training introduces attendees to modeling and simulation of biological systems using MATLAB’s SimBiology and BioPipeline Designer toolboxes. SimBiology is a versatile toolbox for modeling, simulating, and analyzing dynamic Read More...

09/15/2025 - Since 2016, NCI and the U.S. Department of Energy (DOE) have engaged in a strategic, interagency collaboration to simultaneously accelerate advances in precision oncology and scientific computing, including the use of artificial intelligence. The Read More...

08/14/2025 - Biowulf is the NIH Unix-based high-performance computer (HPC). Unix is a command driven computer operating system. Biowulf has more computational power than the average laptop, which makes it ideal for analyzing Next Generation Sequencing ( Read More...

07/21/2025 - Profe or Angela Brook i a leader in the development and application of high-throughput genomic and computational approache to inve tigate gene regulation. Her re earch focu e on characterizing mutation impacting RNA expre Read More...

07/09/2025 - This session of the BTEP Coding Club will demonstrate the use of R programming to perform decision tree analysis, survival tree analysis, and random forest. This event complements a Statistics for Lunch event, " Read More...

06/24/2025 - Tran late gene li t into biological in ight u ing pathway enrichment tool . Thi training will provide an overview the current tatu of pathway tool , with focu on oftware available to NIH community.  Read More...

06/17/2025 - Due to the growing popularity of high-plex patial proteomic and tran criptomic technique , many analy i platform have been propo ed to make en e of the re ulting data. Nonethele , mo t platform Read More...

04/23/2025 - Dr. Ruppin's research is focused on multi-disciplinary, algorithmic, computationally driven analysis of large-scale biomedical omics and clinical data, with an emphasis on AI and machine / deep learning approaches. Overall, it centers on three Read More...

04/10/2025 - TumorDecon is a computational tool at an early stage of contributing to the intersection of bioinformatics and oncology. The goal of TumorDecon is to estimate the percentages of various immune cells from gene expression Read More...

03/26/2025 - This session of the BTEP Coding Club will showcase NIH HPC OnDemand, a new interface for on-demand access to HPC resources via a web browser. HPC OnDemand simplifies access to graphical sessions and GUI Read More...

03/25/2025 - Dr. Ben Raphael will describe computational methods developed in his lab to analyze large-scale biological data related to cancer evolution, genetic variants, and structural variation in cancer genomes. He’ll share combinatorial and statistical Read More...

General questions or comments about the BTEP program or classes should be addressed to: NCIBTEP@nih.gov Amy Stonelake, Ph.D . BTEP Program Manager and Bioinformatics Analyst amy.stonelake@nih.gov I am an experienced Read More...

03/12/2025 - Clustering is one of the fundamental unsupervised machine learning algorithms. It is often used to group quantitative proteomic or RNAseq expression data to suggest sub-types of a particular cancer. This presentation covers building a Read More...

03/11/2025 - Clustering is an unsupervised machine learning technique that groups together similar objects (samples, individuals, etc.). Determining the similarity between objects requires a distance metric. This talk provides a brief overview of distance metrics, hierarchical ( Read More...

01/28/2025 - This talk will cover how our group uses the resources of the FRCE cluster to process cryo-electron microscopy data collected in-house. This session is geared towards beginner users. This session will be recorded, and Read More...

01/15/2025 - This session of the BTEP Coding Club will demonstrate how to use the R package “survival” to conduct a survival analysis of an example dataset.  Senior Programmer and Analyst, Duncan Donohue, PhD, will cover Read More...

01/14/2025 - In this talk, we will cover the basics of survival analysis as a statistical methodology developed for censored data. Special emphasis will be on visualizing survival data, comparing survival-time distributions for subject groups, and Read More...

11/13/2024 - The National Library of Medicine (NLM) Division of Intramural Research (DIR) is pleased to welcome Manisha Desai, PhD, Section Chief of Biostatistics and Director of the Quantitative Sciences Unit at Stanford University School of Read More...

11/12/2024 - We will discuss statistical considerations in planning, executing, and interpreting experiments using animals. Topics will include interpreting minimally powered pilot studies, dealing with complex time series, and maximizing knowledge gain from limited resources. This Read More...

Cancer research is a complex and data-intensive field. Cloud computing offers a powerful solution for researchers to store, analyze, and share large datasets efficiently. In this month’s topic spotlight, we will explore cloud resources Read More...

10/29/2024 - In this presentation, you will get an overview of the Cancer Digital Slide Archive (CDSA) platform. CDSA is an open source, web-based platform for storage, visualization, and management of digitized whole slide images.& Read More...

10/22/2024 - Popular structure prediction program AlphaFold3 and its competitor Chai-1 recently added capabilities to predict 3D RNA structures straight from sequence input. In this talk, we will discuss some test cases for these programs and Read More...

10/08/2024 - We will cover recently developed statistical approaches to the classification of BRCA2 variants using the functional-assay data generated by our NCI collaborators (Dr. Sharan’s lab). Our main objective is to illustrate how statistical Read More...

08/13/2024 - This session will cover the basics of linear mixed-effects modeling as a method of regression analysis for clustered data. Special emphasis will be on the ideas behind random-intercepts and random-slopes modeling, and the discussion Read More...

Clinicians and bench scientists (a.k.a., wet lab researchers) are at the forefront of scientific achievement. However, most, if not all contemporary projects involve robust scientific analysis, where the tools of exploration aren’t Read More...

07/23/2024 - In this presentation, we will demonstrate how to use enterprise data science platform to configure, run, share, and scale downstream bioinformatics and image analysis pipelines using cloud and HPC resources. This session is geared Read More...

07/19/2024 - The molecular mechanisms underlying many types of cancer involve aberrances in trans-acting factors and their binding to cis-regulatory elements to regulate gene expression. Techniques such as ChIP-seq, DNase-seq, and ATAC-seq are commonly used to Read More...

07/17/2024 - Dear Colleagues,   Please join us on Wednesday, July 17, 2024, when Dr. Olivier Gevaert from Stanford University will discuss leveraging data at different scales for personalized diagnosis, prognosis, and therapy in the fields of Read More...

07/09/2024 - Galaxy is a scientific workflow, data integration, data analysis, and publishing platform that makes computational biology accessible to research scientists that do not have computer programming experience. This workshop will cover exome sequencing data Read More...

06/11/2024 - This talk will cover the basics of statistical resampling methods such as bootstrap, Monte Carlo, and permutations for estimating parameters and testing hypotheses.  We will discuss when you might want to use Read More...

06/06/2024 - The Brooks Lab developed a computational tool called FLAIR (Full-Length Alternative Isoform Analysis of RNA) to produce confident transcript isoforms from long-read RNA-seq data with the aim of alternative isoform detection and quantification. With Read More...

06/04/2024 - Galaxy is a scientific workflow, data integration, data analysis, and publishing platform that makes computational biology accessible to research scientists that do not have computer programming experience. This training will introduce ChIP sequencing data Read More...

R is both a computational language and environment for statistical computing and graphics. It is open-source and widely used by scientists, not just bioinformaticians. Base packages of R are built into your initial installation, but Read More...

Due to limits on computational resources, you may be interested in running your analysis on an HPC. Biowulf is the NIH high performance compute cluster. It has greater than 90k processors, and can easily perform Read More...

05/23/2024 - An exciting opportunity at the intersection of the biomedical sciences and machine learning stems from the growing availability of large-scale multi-modal data (imaging-based and sequencing-based, observational and perturbational, at the single-cell level, tissue-level, and Read More...

05/14/2024 - This presentation will explain the difference between the mean and standard deviation of a set of values and the standard error of the mean. The parameters involved in comparing two normally distributed populations relative Read More...

05/07/2024 - Galaxy is a scientific workflow, data integration, data analysis, and publishing platform that makes computational biology accessible to research scientists that do not have computer programming experience. This workshop will introduce RNA-seq data analysis Read More...

05/02/2024 - To register to attend, you must log in to your SITC Cancer Immunotherapy CONNECT account. Don’t have an account?  Create a free one . Join Dr. Mullin of the Roswell Read More...

04/23/2024 - Dr. Stephanie Harmon obtained her Ph.D. in medical physics at the University of Wisconsin–Madison and did her postgraduate training at Leidos Biomedical Research where she worked within the Molecular Imaging Read More...

04/19/2024 - Dear Colleagues,    This webinar will introduce TumorDecon, a computational tool that's at an early stage of contributing to the intersection of bioinformatics and oncology.   TumorDecon aims to Read More...

04/16/2024 - GitHub is a powerful platform for tracking, sharing, and collaborating on software projects of all kinds. Whether you’re a bioinformatics analyst, a software engineer, or a biologist who sometimes codes, GitHub Read More...

04/12/2024 - This session will outline the All of Us Researcher Workbench registration process for NIH researchers. Access to the Researcher Workbench is free, and all registered researchers are provided $300 initial computational credits. Some analyses in Read More...

04/09/2024 - In this talk, we will cover what differentiates parametric and non-parametric statistics, tests/methods of both types for different data scenarios, when to use one vs. the other, and tradeoffs/pitfalls of each. This Read More...

Learning Objectives This tutorial was designed to demonstrate common secondary analysis steps in a scRNA-Seq workflow. We will start with a merged Seurat Object with multiple data layers representing multiple samples. Throughout this tutorial we Read More...

This page uses content directly from the Biostar Handbook by Istvan Albert. Obtain RNA-seq test data. The test data consists of two commercially available RNA samples: Universal Human Reference (UHR) and Human Brain Reference (HBR) . Read More...

09/09/2025 - This event will be in-person only, with no Webex/hybrid option.  We will record the sessions and make them available in the BTEP Video Archive. There is no registration necessary.  Read More...

05/16/2025 - This one-day in-person NIH AI Symposium will bring together researchers from a broad range of disciplines to share their AI-related research, with the goal of disseminating the newest AI research, providing an opportunity to Read More...

This archive contains past and present issues of the  BTEP BioInformatics Bulletin. The BTEP Bioinformatics Bulletin features select upcoming bioinformatics events offered across NIH and is distributed monthly via email to the Center Read More...

nf-core is a community effort to generate a curated set of standardized, best-practice, reproducible, documented, NGS analysis pipelines. All these workflows are built using the versatile workflow manager, Nextflow , and have been released under the Read More...

Recently, the NIH HPC Team has provided on demand access to HPC resources via web browser through integration of Open OnDemand , an open source project supporting "nearly 400 HPC centers around the world" . This Read More...

01/21/2025 - About the Speaker: Hari completed his PhD in Cell Biology at the University of Toronto, where he used single-molecule imaging techniques to reveal how multimolecular interactions govern early signaling events in individual immune cells. Read More...

Listed below are the video recordings of past BTEP events (classes, seminars, workshops). Videos are hosted on various servers and may play slightly differently. Some videos may be downloaded for local viewing. Recorded Videos of Read More...

09/23/2024 - Come to the Fair!  In the morning session, several different groups will speak about their training and education programs. The afternoon session will be devoted to learning about research using AI across Read More...

Congratulations, your experiments have been completed and you have a large amount of data. Now, it’s time to analyze these data. But where do you begin? How can you gain the most meaning from Read More...

Clustering is used to group cells by similar transcriptomic profiles. Seurat uses a graph based clustering method. You can read more about it here . The first step is to compute the nearest neighbors of each Read More...

This lesson provides an introduction to R in the context of single cell RNA-Seq analysis with Seurat. Learning Objectives Learn about options for analyzing your scRNA-Seq data. Learn about resources for learning R programming. Learn Read More...

05/17/2024 - The NIH Artificial Intelligence (AI) Symposium will take place on Friday, May 17th, 2024, in Masur Auditorium in Building 10 on the Bethesda NIH campus. This event is open to all NIH members - registration and Read More...