Search Results for: direct stochastic optical reconstruction microscopy

The CCR Microscopy Core provides NCI investigators access to state-of-the-art imaging tools and techniques, including light sheet fluorescence, high-resolution confocal, multi-photon, and super-resolution microscopy. The mission of the CCR Microscopy Core Facility is to support Read More...

LCMB Microscopy Core offers live cell imaging technologies as well as super-resolution, fluorescence lifetime and confocal imaging systems for immunofluorescence. Our confocal instruments are a Leica SP8 laser scanning confocal microscope and a Nikon spinning Read More...

Electron Microscopy Laboratory (EML) The EML offers investigators access to unique expertise and EM technologies that allow our partners to explore new avenues of research to enhance the knowledge of biological systems. To assist our Read More...

The EML offers investigators access to unique expertise and EM technologies that allow CCR Investigators to explore new avenues of research in order to enhance the knowledge of biological systems. To assist our customers, we Read More...

The LCBG Microscopy Core offers imaging technologies and training. The Core has established instrumentation for for 2D and 3D imaging of both fixed and living specimens.

CCR VOLUME Electron Microscopy (CVEM) aims to develop new techniques in volume electron microscopy (vEM) and, in collaboration with CCR Investigators, apply these techniques to research cell biological questions well-suited for study by high-resolution 3D Read More...

01/28/2025 - This talk will cover how our group uses the resources of the FRCE cluster to process cryo-electron microscopy data collected in-house. This session is geared towards beginner users. This session will be recorded, and Read More...

02/02/2021 - Register In this training, the attendees will learn how advanced pathway and network biology algorithms from the Computational Biology Methods for Drug Discovery (CBDD) toolkit can be applied to a broad range of OMICs Read More...

As a multi-user facility, the different instruments provide a wide range of imaging modes for EIB scientists, from standard immunohistochemistry, through brightfield and wide-field epifluorescence imaging, to highly complex live cell confocal microscopy and super-resolution Read More...

.row { display: flex; justify-content: space-around; align-items: flex-start; margin: 20px; } .column { text-align: center; padding: 10px; width: 30%; } .column img { display: block; margin: 0 auto; width: 150px; height: 150px; } .column strong { display: block; margin-top: 10px; } Background: Intravital microscopy (IVM) Read More...

The identification of cell types in single cell genomics data (cell type annotation) can provide new insights into cellular identities, heterogeneity, and functional roles. Cell type annotation is challenging Read More...

05/06/2021 - Presenter : Adam J Gayoso, Streets and Yosef Groups at UC Berkeley Abstract : Probabilistic models have demonstrated state-of-the-art performance for many single-cell omics data analysis tasks, including dimensionality reduction, clustering, differential expression, annotation, removal of Read More...

The total number of detected transcripts expressed in a cell is dependent on the amount of mRNA in a cell. Cells naturally vary in the total amount of mRNA expressed. However, the chemistry of the Read More...

Before jumping into submitting scripts in job files, let's first focus on how to run R from the command line. The primary way to run R from the command line is to call Rscript . Read More...

Used for data transfers and file management on a large scale. 48 core system with 1.5 TB of main memory direct internet connection Helix should be used when you are transferring >100 GB using scp gzipping a Read More...

03/23/2023 - This afternoon workshop will give attendees an understanding of how single cell technologies are used to study cancer. To start us off, Mike Kelly , head of the Single Cell Analysis Facility (SCAF), will give Read More...

04/10/2019 - BTEP Wednesday, April 10, 2019 9:00 am  |  Eastern Daylight Time (New York, GMT-04:00)  |  2 hrs Meeting number (access code): 738 427 711 Meeting password: zPJpWP$6     10x Genomics: Whole Exome and Whole Genome Analysis How 10x Genomics linked Read More...

12/05/2018 - THIS EVENT HAS BEEN CANCELLED 10x Genomics: Whole Exome and Whole Genome Analysis How 10x Genomics linked reads works SNVs, copy number variations, structural variants and phasing of the variants from linked read data Read More...

10/26/2018 - 10x Genomics: Whole Exome and Whole Genome Analysis How 10x Genomics linked reads works SNVs, copy number variations, structural variants and phasing of the variants from linked read data Walk through of 10x Genomics Read More...

10/02/2012 - Microarray Technology and Preprocessing Quality Control Normalization Using MAS5 and RMA Filtering Batch Effect Correction Basic Statistical Tests for Differentially Expressed Genes T-test ANOVA SAM Calculating False Discovery Rate Principal Components Analysis and Clustering Read More...

Rstudio is the ideal Desktop client for those interested in getting started with R. RStudio is an integrated development environment (IDE) for R. It includes a console, syntax-highlighting editor that supports direct code execution, as Read More...

Volume electron microscopy: A powerful, nanoscale-resolution, 3D imaging approach now available to the cell biologist Kedar Narayan, Ph.D., Senior Scientist & Group Leader, CCR Volume Electron Microscopy, Cancer Research Technology Program (CRTP), Frederick National Laboratory, Read More...

Our Team Tatiana S. Karpova Ph.D.Core Headkarpovat@nih.govBuilding 41, Room C615240-760-6637 David A. Ball Ph.D.Core Biologistballa@nih.govBuilding 41, Room B114D240-760-6577 Mohamadreza Fazel, Ph.D.Core Biologistmohamadreza. Read More...

Long read sequencing was recently named 2022’s method of the year by Nature Methods . Long read sequencing technologies, those that generate sequence reads with lengths of 10s of kilobases or longer have several advantages over Read More...

There are a number of core facilities available to NCI researchers. See more information from the Office of Science and Technology Resources. We most commonly see data from the following cores: CCR Sequencing Facility (CCR-SF) Read More...

05/29/2025 - Prostate cancer exhibits significant intratumoral heterogeneity, driving a spectrum of phenotypes ranging from indolent disease to aggressive metastasis, challenging risk stratification and treatment. A key feature of this heterogeneity is clonal diversity, encompassing both Read More...

11/13/2024 - In this webinar, Dana-Farber Cancer Institute’s Dr. Renato Umeton will explore the transformative journey of applying artificial intelligence (AI) solutions at scale, and in full compliance, bridging the gap between Big Read More...

10/17/2024 - Please join us on Thursday for our third talk in the Biowulf 25th Anniversary Seminar Series: Explorations in use of Synthetic Images for Biomedical ML/AI Research This talk will be videocast at: https:// Read More...

According to Wikipedia, a path is "a string of characters used to uniquely identify a location in a directory structure." Therefore, a file path simply tells us where a file or files are Read More...

10/03/2023 - Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Significant advances in the field now allow high-parameter data collection (60+ targets); however, considerable expertise and capital are needed to validate Read More...

To complement this course, we have created a Biostars module on Biowulf. The following programs have been included in that module: Apps/Dependencies: bbtools bcftools bedtools bio bioawk blastn bowtie2 bwa cd-hit csvkit csvtk cutadapt Read More...

Biostars Software Description To complement this course, we have created a Biostars module on Biowulf. The following programs have been included in that module: Apps/Dependencies: bbtools bcftools bedtools bio bioawk blastn bowtie2 bwa cd-hit Read More...

For multi-threaded jobs, you will need to set --cpus-per-task . You can do this at the command line or from within your script. Example at the command line: $ sbatch --cpus-per-task=# yourscript.sh In your script: #!/bin/ Read More...

Biowulf computational nodes use a Unix-like (Linux) operating system (distributions RHEL8/Rocky8). Unix is a proprietary operating system like Windows or MacOS (Unix based). There are many Unix and Unix-like operating systems, including open source Read More...

Unix is a proprietary operating system like Windows or MacOS (Unix based). There are many Unix and Unix-like operating systems, including open source Linux and its multiple distributions. Biowulf computational nodes use a Unix-like (Linux) Read More...

05/25/2023 - Dr. Katherine Janeway is a pediatric hematologist-oncologist and investigator at the Dana-Farber Cancer Institute with a research focus of pediatric sarcomas. With her presentation "Count Me In: Partnering with Patients to Define the Read More...

According to Wikipedia, a path is "a string of characters used to uniquely identify a location in a directory structure." Therefore, a file path simply tells us where a file or files are Read More...

11/09/2022 - Since its release in September 2005, the Gene Set Enrichment Analysis (GSEA) software and its companion gene set collections, the Molecular Signatures Database (MSigDB) have served as key resources for interpreting the biological significance of Read More...

09/12/2022 - We welcome members of the NIH to join us for a seminar event, covering multiplexed, direct digital gene expression profiling applications utilizing NanoString nCounter expression profiling technology as well as spatial biology discoveries generated Read More...

08/24/2022 - Meeting Link: https://cbiit.webex.com/cbiit/j.php?MTID=m875b987cd37fafd4c24a84b7296aadb0 This webinar will demonstrate new features for creating publication ready RNA-Seq Graphs using the easy Point-and-Click Read More...

04/20/2022 - During this seminar, Dr. Clemens Grassberger will highlight: current computational and mathematical approaches for modeling the impact of radiotherapy on the immune system, and how to design the next generation of combination trials. The Read More...

11/16/2021 - Presenter: Rahul Satija, PhD, is a Core Faculty Member at the New York Genome Center (NYGC), with a joint appointment as Associate Professor at the Center for Genomics and Systems Biology at New York Read More...

04/13/2021 - Workshop Registration Dear NIH colleagues, You are invited to participate in the Machine Learning in Genomics: Tools, Resources, Clinical Applications, and Ethics Workshop , held virtually on Tuesday, April 13 – Wednesday, April 14, 2021. Information about the agenda, Read More...

04/12/2021 - Tumor heterogeneity and plasticity provide a driving force for tumor progression and metastasis as well as treatment response. Tumor heterogeneity can be explained by the same mechanisms that govern the developmental programs of an Read More...

04/05/2021 - Dear colleagues, We'll be hosting a special guest lecture by Prof. John Moult from UMD. Abstract: Computing the three-dimensional structure of a protein molecule from its amino acid sequence is a long-standing grand Read More...

01/12/2021 - Please plan to attend the Earl Stadtman Investigator Program search seminar by: Mikhail Kolmogorov, Ph.D. University of California, San Diego Dr. Kolmogorov's research focus is bioinformatics. Particularly, he is interested in algorithms Read More...

05/09/2018 - Driven by the decreasing costs and increasing performance of next-generation sequencing (NGS) technologies, the amount of publicly available genomic data has grown exponentially in recent years.  While most of the analyses of these data Read More...

12/13/2016 - Driven by the decreasing costs and increasing performance of next-generation sequencing (NGS) technologies, the amount of publicly available genomic data has grown exponentially in recent years.  While most of the analyses of these data Read More...

According to Wikipedia, a path is "a string of characters used to uniquely identify a location in a directory structure." Therefore, a file path simply tells us where a file or files are Read More...

Used for data transfers and file management on a large scale. 48 core system with 1.5 TB of main memory direct internet connection Helix should be used when you are transferring >100 GB using scp gzipping Read More...

Used for data transfers and file management on a large scale. 48 core system with 1.5 TB of main memory direct internet connection Helix should be used when you are transferring >100 GB using scp gzipping Read More...

In lesson 1, you learned about the NIH HPC cluster, Biowulf. Biowulf nodes use a Unix-like (Linux) operating system (distributions RHEL8/Rocky8), which requires knowledge and use of the command line interface (shell) to direct computational Read More...

We see a similar organization of information for other annotation categories. For instance, DAVID pulls information on biomolecular processes, functions, and pathways from several sources such as UniProt, GO, KEGG, Reactome, and Wikipathways. For Gene Read More...

Unix is a proprietary operating system like Windows or MacOS (Unix based). There are many Unix and Unix-like operating systems, including open source Linux and its multiple distributions. Biowulf nodes use a Unix-like (Linux) operating Read More...

Unix is a proprietary operating system like Windows or MacOS (Unix based). There are many Unix and Unix-like operating systems, including open source Linux and its multiple distributions. Biowulf nodes use a Unix-like (Linux) operating Read More...

Qlucore Omics Explorer (Qlucore) is a graphical user interface (GUI) based package used for -omics data anlaysis. Qlucore Omics Explorer can analyze many types of -omics data that are in tabular format (e.g., RNA Read More...

In high-performance computing, multithreading lets a single program split itself into multiple "workers" that can run at the same time on different parts of the computer's brain (CPUs), speeding up complex tasks. Read More...

A high-performance visualization tool for interactive exploration of large, integrated genomic datasets. One favorite use is inspection of alignments to rule out alignment artifacts resulting in false-postive variant calls.The Integrative Genomics Viewer (IGV) is Read More...

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies: CIPS can Read More...

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and Read More...

The Mouse Imaging Facility (MIF) is a shared, trans-NIH intramural resource for animal imaging studies. MIF provides access to state-of-the-art radiological imaging methods optimized for mice, rats, other animals, and tissue samples. MIF provides intellectual, Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. We would greatly appreciate Read More...

The function of the SAIP is to collaborate with NCI investigators in the development of mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies Read More...

The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization, and utilization of models of human disease. The initiative approach includes both Read More...

The Center for Advanced Tissue Imaging (CAT-I) is an NIAID and NCI supported effort involving collaborative studies between experts in the Laboratory of Immune System Biology, DIR, NIAID and investigators in the DIR, NIAID and Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Cores on CREx NIBIB BEPS Micro Analytical Immunochemistry Unit The Micro Analytical Immunochemistry Unit employs a variety Read More...

The NCI High-Throughput Imaging Facility (HiTIF) works in a collaborative fashion with NCI/NIH Investigators by providing them with the necessary expertise, instrumentation, and software to develop and execute advanced High-Throughput Imaging (HTI) assays. These Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. If you haven’t Read More...

The NIH MRI Research Facility (NMRF) is a shared, intramural resource for human imaging studies. The NMRF is supported by all Institutes at NIH and reports to the Shared Resources Subcommittee (SRS) of the Scientific Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Research Festival The NIH Research Festival highlights the groundbreaking science and the vibrant NIH community driving our Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Advance your research with the NIH Mouse Imaging Facility (MIF) The NIH Mouse Imaging Read More...

Back Services: This instrument is not user accessible.  We provide both data collection and data analysis services. Location: Building 50, room 3331 Description: An analytical ultracentrifuge is equipped with absorption and interference optical systems that monitor Read More...

CREx News & Updates July 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...

October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NIH Center For Human Immunology, Inflammation, And Autoimmunity (CHI) CHI is a Read More...

Back Services: Biophysics Facility offers DSC as an open-access instrument. First-time users must complete training before gaining access to the instrument reservation calendar. Location: Building 50, room 3123 Description: The differential scanning calorimeter measures the constant pressure Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx Program Manager The CREx Team is happy to announce Deepika Velampati as the new CREx Program Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural Core Resources NHGRI Flow Cytometry Core The Core performs high quality single cell analysis through the Read More...

Many established and emerging technologies are available to CCR scientists.  This technology-rich environment makes the CCR a unique place to conduct scientific research.  Through the OSTR, the CCR continues to find Read More...

This is part II of the article highlighting nf-core pipelines and specifically addresses the use of these pipelines in the DNAnexus cloud environment. Part I of the article can be found in the October 2023 topic Read More...

nf-core is a community effort to generate a curated set of standardized, best-practice, reproducible, documented, NGS analysis pipelines. All these workflows are built using the versatile workflow manager, Nextflow , and have been released under the Read More...

10/24/2024 - Recent advances in artificial intelligence (AI) have revolutionized the use of hematoxylin and eosin (H&E)-stained tumor slides for precision oncology, enabling data-driven approaches to predict molecular characteristics and therapeutic outcomes. In Read More...

Clustering is used to group cells by similar transcriptomic profiles. Seurat uses a graph based clustering method. You can read more about it here . The first step is to compute the nearest neighbors of each Read More...

09/06/2023 - With the advancements in single cell and spatial profiling technologies and methods, some of us thought it would be helpful to re-establish a community of end users on campus. We invite those that are Read More...

This page contains content directly from the Biostar Handbook by Istvan Albert. Always remember to activate your bioinformatics environment. conda activate bioinfo What is a sequence pattern? A sequence pattern is a sequence of bases Read More...

For this tutorial, you will be using either your own Biowulf account, or a student account. If you do not have a Biowulf account, see the instructor to get the login and password for a Read More...

This page uses content directly from the Biostar Handbook by Istvan Albert. Always remember to start the bioinformatics environment when working on Biostar class material. conda activate bioinfo Let's start by creating a directory Read More...

05/19/2023 - Patient-derived cancer models (PDCM) have become an essential tool in both cancer research and preclinical studies. Each model type offers unique advantages and is better suited for specific research areas: cell lines are low Read More...

04/20/2021 - Abstract: Single-cell genome-wide profiling offers an approach to map transitional cell states during cell differentiation, disease onset, and drug response. Lineage-tracing, in which cells are labeled with hereditary markers, offers an approach to establishing Read More...

02/20/2020 - Learn how to easily analyze your gene expression data yourself - using Qlucore Omics Explorer NCI/CCR:To get access to Qlucore, put a request into NCI at Your Service under Get Help https:// Read More...

02/12/2020 - This two-day instructor-led course gives participants a broad study of networking options on Google Cloud Platform. Through presentations, demonstrations, and hands-on labs, learners explore and deploy GCP networking technologies, such as Google Virtual Private Read More...

09/26/2019 - Qlucore Omics Explorer is an interactive analysis and visualization tool that helps the user to find groups, structures, variable networks and discriminating variables. You can use your own data and analyze public data. Omics Read More...

The CCR Collaborative Bioinformatics Resource (CCBR) is a resource group which provides a mechanism for CCR researchers to obtain many different types of bioinformatics assistance to further their research goals. The group has expertise in Read More...

CREx News & Updates January 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NCI ANTIBODY CHARACTERIZATION LABORATORY (ACL) The ACL specializes in rigorously validating antibodies for signaling and Read More...

The CPP is directly responsible for the pharmacokinetic (PK) analysis of numerous Phase I and II clinical trials conducted within the NCI. In addition, the CPP provides direct PK support for many studies performed elsewhere Read More...

September 8, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight Trans-NIH Intramural Sequencing Center (NISC) NISC is a multi-disciplinary genomics facility that Read More...

The introduction of DNA sequencing instruments capable of producing millions of DNA sequence reads in a single run has profoundly altered the landscape of genetics and cancer biology. Complex questions can now be answered at Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Derive Greater Insights and Accelerate your Research Using Bioinformatic Tools! CREx is an NIH Read More...

The Biomedical Engineering and Physical Science (BEPS) shared resource supports NIH’s intramural basic and clinical scientists on applications of engineering, physics, imaging, measurement, and analysis. BEPS is centrally located on the main NIH campus Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Interested in imaging large scale biological samples?  Volume electron microscopy allows for Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Technology Event Biophysical Methods for Protein Interactions Monday, May 15 – Friday, May 19, 2023 This workshop will review the strategies of Read More...

The Division of Veterinary Resources Animal Surgery has supported large animal research and clinical care for more than 40 years. DVR surgeons provide outstanding and highly specialized large animal (rabbits, ungulates, etc.) research support in a Read More...

[tabby title="Home"] About NICE-NIH Intramural CryoEM Consortium  NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of Read More...

The Pathology Service, Division of Veterinary Resources (DVR), Office of Research Services (ORS), provides diagnostic gross and histopathologic evaluation of any species of laboratory animals used in the NIH Intramural Research Program due to morbidity, Read More...

October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Spotlight The NIH Lab Managers Working Group have developed a new NIH-wide database of cold Read More...

The Neurorehabilitation and Biomechanics Research Section (also referred to as the NAB LAB) is a multidisciplinary group of highly qualified scientists, clinical and technical staff, and trainees with diverse backgrounds including medical, physical therapy, neuroscience Read More...

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes. Established Technologies: Cardiovascular Phenotyping, Metabolic Phenotyping, Pulmonary Phenotyping, Behavioral Phenotyping, Exercise Physiology, Read More...

The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell-based assays, in vivo imaging studies, and Read More...

Services: Biophysics Facility offers CD as an open-access instrument.  First-time users must complete a short training session before gaining access to the instrument reservation calendar. Location: Building 50, room 3123 Description: CD spectroscopy measures the difference Read More...

Back Services: Biophysics Facility offers CD as an open-access instrument.  First-time users must complete a short training session before gaining access to the instrument reservation calendar. Location: Building 50, room 3123 Description: CD spectroscopy measures the Read More...

In support of Intramural Research Program (IRP) scientists, DOHS provides training, consulting, and resources to ensure that workers' risk to hazards and stresses in the laboratory environment is minimized. Our services include one-on-one consultation with Read More...

NISC’s role within NHGRI, and more broadly across NIH, aims to advance genome sequencing and its many applications, with a goal not simply to produce sequence data, but to produce the infrastructure required to Read More...

October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

The FNLCR Molecular Histopathology Laboratory (MHL) provides comprehensive veterinary pathology support for animal health monitoring, biomarker discovery and validation, drug development, genomics, and proteomics on a cost recovered basis. The MHL is organized into multiple Read More...

The OSTR offers cutting-edge technology platforms to the CCR scientific community through centralized facilities. The videos accessed through this page are designed to introduce the various scientific methodologies OSTR makes available through the cores on Read More...

Supplemental Technology Award Review System (STARS) Overview STARS Request Form STARS System The Supplemental Technology Award Review System (STARS) is a web-based interface for submission and review of S&S supplement requests by CCR Read More...

Learning Objectives This tutorial was designed to demonstrate common secondary analysis steps in a scRNA-Seq workflow. We will start with a merged Seurat Object with multiple data layers representing multiple samples. Throughout this tutorial we Read More...

Learning Objectives To understand: 1. the difference between R and RStudioIDE. 2. how to work within the RStudio environment including: creating an Rproject and Rscript navigating between directories using functions obtaining help how R can enhance data Read More...

Lesson 5: Working on Biowulf Lesson 4 Review Flags and command options Wildcards ( * ) Tab complete Accessing user history with the "up" and "down" arrows cat , head , and tail Working with file content (input, Read More...

Lesson 4: Submitting R Scripts via command line Learning Objectives Learn how to use R with less interaction Learn how to deploy sbatch R jobs, and learn about alternatives such as swarm . Learn about R job Read More...

Lesson 1: Introduction to Biowulf, Unix, and R Learning Objectives Learn about why you may want to use R on Biowulf. Refresh Unix and R skills. This lesson will not be hands on. Why use R Read More...

Learning Objectives Understand the components of an HPC system. How does this compare to your local desktop? Learn about Biowulf, the NIH HPC cluster. Learn about the command line interface and resources for learning. What Read More...

Introduction to R and RStudio IDE Objectives To understand: 1. the difference between R and RStudioIDE. 2. how to work within the RStudio environment including: creating an Rproject and Rscript navigating between directories using functions obtaining help 3. Read More...

05/22/2017 - Driven by the decreasing costs and increasing performance of next-generation sequencing (NGS) technologies, the amount of available genomic data has grown exponentially in recent years.  While most of the analyses of these data is Read More...

Changes to a coding project (including scripts, data, and other content) should be saved periodically, similar to clicking on the "save" button to periodically save changes when constructing a word document. This is Read More...