The CCR Animal Resource Program (ARP) plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. Coordinates the use of animal holding spaces within the NCI animal facilities, NIH central animal facilities, and shared animal facilities., Oversees the use of all centrally funded animal resources., Assists with cost-effective options for animal technical support, off-site animal contracts., Coordinates/negotiates animal-related interagency agreem… [learn more]

The Biological Products Core provides the AIDS research community with high-quality purified preparations of various strains of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV), economically prepared by leveraging the economy of scale. Materials provided include chemically inactivated virus prepared by treatment with Aldrithiol-2. This chemical inactivation method was developed by AIDS and Cancer Virus Program personnel and eliminates infectivity while preserving functional surface proteins, including envelope glycoproteins. This property makes them attractive prepara… [learn more]

The Biological Products Core provides the AIDS research community with high-quality purified preparations of various strains of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV), economically prepared by leveraging the economy of scale. Materials provided include chemically inactivated virus prepared by treatment with Aldrithiol-2. This chemical inactivation method was developed by AIDS and Cancer Virus Program personnel and eliminates infectivity while preserving functional surface proteins, including envelope glycoproteins. This property makes them attractive prepara… [learn more]

The CCR Building 41 Flow Cytometry Core is a full-service facility within the Center for Cancer Research that supports over 150 users representing 26 laboratories. The Core Facility provides instrument and software training, technical expertise, assay development, and experimental design for all users. The Core also offers sample preparation protocols and reagent recommendations, including fluorochrome panel setups for each flow cytometer and reagent cross-reactivity among species. The Core Manager provides assistance with data analysis and figure preparation for flow cytometry data presentat… [learn more]

The EML offers investigators access to unique expertise and EM technologies that allow CCR Investigators to explore new avenues of research in order to enhance the knowledge of biological systems. To assist our customers, we provide complete specimen preparation service which includes shipment of fixative, processing, embedding, sectioning, and imaging of samples. If desired, investigators can also discuss the design of custom protocols tailored to their specific needs. EML is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Establis… [learn more]

The CCR Genomics Core is located in Building 41 on the NIH Bethesda campus. The primary goal of the Core is to provide investigators from CCR/NCI and other NIH Institutes access to genomic technologies and Next-Generation Sequencing (NGS) with rapid turnaround on smaller-scale projects or projects that are not ready for production. The Core is unique in granting user-accessible instrumentation. Additional resources include training, consultation services, bioinformatics support, and secure data delivery/management. We also provide DNA and RNA quality control (QC) services. The facility operate… [learn more]

OMAL focuses its research and development activities to quantitatively understand the molecular basis of three-dimensional (3D) cell organization, motility, invasion, and differentiation using fixed samples and live, 3D tissue culture models (i.e., translational models). OMAL is a CCR-dedicated facility. Prospective users and collaborators should first consult the following website before contacting OMAL staff: OMAL Website. OMAL is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Established Optical Microscopy Technologies Bri… [learn more]

Protein and Metabolite Characterization Core offers various technologies to CCR investigators to characterize proteins and metabolites. The core develops and applies state-of-the-art analytical technologies, primarily mass spectrometry, and liquid chromatography, to advance the understanding of cellular function at the protein, proteomics, metabolite, and metabolomic levels. It engages in both short and long-term collaborations based on the need of each project. It is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Expertise and Tec… [learn more]

Protein and Metabolite Characterization Core offers various technologies to CCR investigators to characterize proteins and metabolites. The core develops and applies state-of-the-art analytical technologies, primarily mass spectrometry, and liquid chromatography, to advance the understanding of cellular function at the protein, proteomics, metabolite, and metabolomic levels. It engages in both short and long-term collaborations based on the need of each project. It is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Expertise and Tec… [learn more]

The rapid advancement of single-cell technology has provided new powerful tools to answer many biological questions, such as identifying new or rare cell populations and characterizing the complexities of tumor heterogeneity. Realizing the great potential of single-cell technology in cancer research, the CCR has established the Single Cell Analysis Facility (SCAF) located on the Bethesda main campus. The SCAF works closely with CCR Sequencing Facility to also extend support to CCR Investigators located in Frederick, and works with other associated support groups at CCR, including CCR Genomics … [learn more]

The rapid advancement of single-cell technology has provided new powerful tools to answer many biological questions, such as identifying new or rare cell populations and characterizing the complexities of tumor heterogeneity. Realizing the great potential of single-cell technology in cancer research, the CCR has established the Single Cell Analysis Facility (SCAF) located on the Bethesda main campus. The SCAF works closely with CCR Sequencing Facility to also extend support to CCR Investigators located in Frederick, and works with other associated support groups at CCR, including CCR Genomics … [learn more]

The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The BR operates as an open, shared-use facility; in general, BR users learn to operate the instruments and conduct their own experiments. Biophysics Resource staff members train all first-time users and are also available to consult with investigators on experimental design/analysis or collaborate with them on more complex studies. Some of … [learn more]

The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell-based assays, in vivo imaging studies, and translational research leading to better disease diagnosis and therapy. It comprises a core synthesis facility dedicated to the preparation of imaging probes, including radiolabeling for PET and SPECT applications, and a research component dedicated to the discovery of new imaging approaches and compositions. Established Technologies PROTA… [learn more]

The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell-based assays, in vivo imaging studies, and translational research leading to better disease diagnosis and therapy. It comprises a core synthesis facility dedicated to the preparation of imaging probes, including radiolabeling for PET and SPECT applications, and a research component dedicated to the discovery of new imaging approaches and compositions. Established Technologies PROTA… [learn more]

CLIA-Certified Technologies Offered: Fragment Analysis for Micro-satellite Instability Detection, Pharmacoscan Array for Pharmacogenomics, Mutation Detection for PCR and Sanger Sequencing, DNA extraction from whole blood, saliva, FFPE tissues, buccal swabs, nails, hair, PBMCs, buffy coats, plasma, tissue slides, cell lines, frozen tissues, and platelet-depleted whole blood, Droplet Digital PCR (ddPCR), Mass Spectrometry, Additional Capabilities Include: Quantitative PCR (qPCR), Next-Generation Sequencing (NGS), Automated Staining (RNAscope), Gene… [learn more]

The Pharmacogenetics Core is responsible for correlating outcome observations (toxicity, efficacy, survival, PK/PD) with genetic variants (germline or somatic) to identify key genetic determinants and biomarkers that predict response to specific treatments. We also evaluate the impact of genetic variants on drug metabolism, transport, and molecular targets that influence drug resistance or contribute to inter-individual variation in therapeutic outcomes. [learn more]

The PPS encompasses all scientific analyses related to pharmacology, once the specimen has been collected and stored. There is a multi-step process to evaluate how the drug is being handled by the body after administration. The first step is to measure the drug concentrations longitudinally. This step is performed by the CPP’s Bioanalytical Unit: Bioanalytical Unit The Bioanalytical Section of the CPP is responsible for the measurement of drug concentrations in samples, either clinical or nonclinical. Our facility is staffed by a PhD Staff Scientist/Deputy Head of the CPP, a PhD la… [learn more]

The Clinical Support Laboratory offers processing, tracking, and testing of a broad range of clinical samples. Support can begin at the early stages of clinical trial development to aid in developing a comprehensive strategy for sample collection, processing, and testing with a special emphasis on immunologic testing. The lab collaborates with partners to develop customized assays or transfer existing assay technology with assay validation, data analysis and interpretation of results. Processing specializes in PBMC isolation and controlled rate freezing, ELISA based biomarker testing, and … [learn more]

Clinical Support Laboratory – Cellular Immunology offers a spectrum of bioassays to assess cellular responses to antigens and mitogens including ELISPOT, cytotoxicity assays, and proliferation assays. Established Technologies Elispot Assays, Dual or Triple Color Fluorospot Assays, Murine Immunoassays, Cytotoxic T cell assays (Chromium Release Assays), Antigen and mitogen-induced cell proliferation, Mixed Lymphocyte Reactions, Antibody-Dependent Cell-Mediated Cytotoxicity, Cell Metabolic Analysis via Seahorse, In vitro Stimulation/Cytoki… [learn more]

The Frederick Sequencing and Genomics Core (FSGC) was established through the integration and consolidation of the former Sequencing Facility and the Genomics Technology Laboratory. The new FSGC eliminates redundancy and provides cutting edge sequencing technologies and assay development capabilities to the NCI. NGS services are made available to NIAID Division of Intramural Research (DIR) through a negotiated MOU.  This core is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory.Next-generation Sequencing Production Group (previously Sequ… [learn more]

The LCBG Microscopy Core offers imaging technologies and training. The Core has established instrumentation for for 2D and 3D imaging of both fixed and living specimens. [learn more]

LCMB Microscopy Core offers live cell imaging technologies as well as super-resolution, fluorescence lifetime and confocal imaging systems for immunofluorescence. Our confocal instruments are a Leica SP8 laser scanning confocal microscope and a Nikon spinning disk confocal microscope. We also house a Total Internal Reflection Fluorescence (TIRF) microscope with capability to perform super-resolved Single Molecule Localization Microscopy and incuabtion chamber equipped epi-fluorescence imaging systems for long-term live-cell imaging experiments. Established Technologies Live cell imagin… [learn more]

The Flow Cytometry Core (LGI) offers established technologies to support studies using flow cytometry and cell sorting. Established Technologies Applications that run on FACS Caliburs include: Immunophenotyping (up to 4-color), Intracellular markers, including cytokines and phosphoproteins, Cell cycle analysis using propidium iodide for mammalian cells and cytox green for yeast, Cell cycle-associated BRDU labeling of S-phase cells and phosphohistone H3 labeling of mitotic cells, Apoptosis by annexin V binding, TUNEL, caspase, or FLICA, Detection o… [learn more]

The core provides access to several different state-of-the-art 3D microscopes as well as computers to visualize and process image data. The facility houses equipment for 2D or 3D imaging of fixed and living specimens. High resolution images can be obtained by confocal microscopy or deconvolution, and super-resolution techniques SIM, STORM, MINFLUX. Single Molecule tracking is supported on MINFLUX, and custom HILO-illumination microscopes. Established Technologies Facility personnel are available for consultation about the design of imaging experiments and/or the analysis of image data. Speci… [learn more]

The Advanced Biomedical Computational Sciences (ABCS) group provides technology development, scientific consultation, collaboration and training, research, software development, and high-performance computing support. ABCS encompasses specialized groups focusing on machine learning applied to the interpretation of 2D and 3D biomedical images, clinical and genomics integration, computational chemistry, bioinformatic analysis of omics data, and other applications of computational and data science. In addition, ABCS offers access to databases and software resources for bioinformatics, image analy… [learn more]

The CCR-Frederick Flow Cytometry Core Facility provides research support to the Frederick-CCR community, including cytometry analysis and sorting services, instrument maintenance, new user training, and technical consultation. Typical Assays Performed by Core Instruments Immunophenotyping of mouse and human cells, Apoptosis assays, including Annexin V, TUNEL, caspase activation, or mitochondrial membrane potential, Cell cycle (DNA content) analysis, Cell health and proliferation monitoring, Sterile Cell sorting (physical separation) for bulk collection or deposition in … [learn more]

The CPP is directly responsible for the pharmacokinetic (PK) analysis of numerous Phase I and II clinical trials conducted within the NCI. In addition, the CPP provides direct PK support for many studies performed elsewhere in the extramural community. The program provides bioanalytical support (LC-MS) and pharmacokinetic-pharmacodynamic (PK/PD) modeling and simulation of investigational agents or combination therapies to predict exposure-response in future trials (Pharmacometrics Core). The CPP can also assist with determining protein binding, drug-drug interactions, concentration-effect anal… [learn more]

The Blood Processing Core monitors viral load in patients with HIV and performs sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease, or other diseases associated with immunologic dysfunction. The core collects clinical specimens from inpatient units and clinics within the National Institutes of Health Clinical Center. We then oversee the processing and cryopreservation of human serum, plasma, peripheral blood mononuclear cells, and other specimens. Our technicians are also trained and qualified to execute preclinical animal protocols and ro… [learn more]

Clinical Support Laboratory – Flow Cytometry Section is a laboratory specializing in providing immunophenotyping support of NCI intramural clinical trials, though assessments may also be performed using cells from Non-human primates and other species. The CSL Flow cytometry core is operated by Leidos Biomedical Research Inc. on behalf of NCI as part of the Frederick National Laboratory. Established Technologies Immunophenotyping (up to 15-color), Specialized immunophenotyping for clinical trial research – ICS and tetramer staining also available.  Frequently customized panels are… [learn more]

The Genomics and Pharmacology Facility is part of the NCI's Center for Cancer Research (CCR), within the Developmental Therapeutics Branch. Its mission is to manage and assess molecular interaction data obtained through multiple platforms, increase the understanding of the effect of those interactions on the chemosensitivity of cancer, and create tools that will facilitate that process. Translation of that information will be directed towards the recognition of diagnostic and therapeutic cancer biomarkers and directed cancer therapy. Established Technologies The Miner Suite of Bioi… [learn more]

The Cancer and Inflammation Program – Microbiome and Genetics Core (CIP-MGC) grew out of the former CIP Genetics Core to meet the increasing need for sequencing and analysis of commensal microbiota within CIP and NCI. The MGC team specializes in: Sample handling, purification, and 16S sequencing, Bioinformatic processing and computational analysis of sequenced reads, Support in genetics and statistical epidemiology , [learn more]

The Animal Diagnostic Laboratory (ADL) provides a full range of diagnostic capabilities, including microbiological cultures on various culture medium, microscopic screening for parasites such as mites and pinworms, molecular detection of pathogens, serological evaluation of antibodies, and necropsy. The High-Throughput Animal Genotyping Lab (HTAGL) within ADL utilizes robotic liquid handling systems to assist in the genotyping of mice using quantitative PCR or end-point PCR analysis. Technologies Molecular Testing of Biological Materials (MTBM), Molecular diagnostic for murine pathog… [learn more]

The Animal Diagnostic Laboratory (ADL) provides a full range of diagnostic capabilities, including microbiological cultures on various culture medium, microscopic screening for parasites such as mites and pinworms, molecular detection of pathogens, serological evaluation of antibodies, and necropsy. The High-Throughput Animal Genotyping Lab (HTAGL) within ADL utilizes robotic liquid handling systems to assist in the genotyping of mice using quantitative PCR or end-point PCR analysis. Technologies Molecular Testing of Biological Materials (MTBM), Molecular diagnostic for murine pathog… [learn more]

NCI LASP Animal Research Technology Support (ARTS) provides customized technical support for basic and translational animal-based research to the scientific community. We offer a wide array of services ranging from expert colony management to the performance and development of technical procedures aimed at the disease induction, characterization, and treatment of animal models. Technologies Development and implementation of specialized technical procedures for induction and characterization of tumorigenesis in preclinical animal models, Assessment of PK/PD and efficacy of investigati… [learn more]

NCI LASP Genome Modification Core (GMC) is a CCR-dedicated facility that provides advice, training, and reagents to NCI scientists seeking to utilize CRISPR and other nucleases to generate genome modifications in primary cells, cell lines, and in animal models. Established Technologies We are currently offering a variety of services to CCR investigators. Moreover, we also have accumulated many different flavors of genome editing reagents. Here is a brief summary of what we are currently offering: Consulting – If you are new to these areas of research and wish to find out more … [learn more]

NCI LASP Genome Modification Core (GMC) is a CCR-dedicated facility that provides advice, training, and reagents to NCI scientists seeking to utilize CRISPR and other nucleases to generate genome modifications in primary cells, cell lines, and in animal models. Established Technologies We are currently offering a variety of services to CCR investigators. Moreover, we also have accumulated many different flavors of genome editing reagents. Here is a brief summary of what we are currently offering: Consulting – If you are new to these areas of research and wish to find out more … [learn more]

The Laboratory Animal Sciences Program (LASP) of the Frederick National Laboratory operates a Gnotobiotics Facility (GF) to support research focused on the role of microbiota in cancer inflammation, pathogenesis, and treatment response. The GF can rederive mice into germ-free status, expand colonies of axenic and gnotobiotic mice, and maintain microbiome-defined lines of animals. The team also has extensive experience working with animal models in basic and translational research, particularly in the fields of immunology and cancer. The GF works closely with Investigators throughout all sta… [learn more]

Mouse models of human cancer have had a profound impact on our current understanding of the mechanisms of tumorigenesis and the pathways regulated by cancer-related genes. These models hold the promise of serving as critical tools in the discovery and testing of novel therapeutics to be used in the treatment and prevention of cancer. The Transgenic Mouse Model Laboratory (TMML) provides assistance to the scientific community with the generation of genetically engineered mice (GEM), offering a complete array of services aimed at the successful generation of tran… [learn more]

Mouse models of human cancer have had a profound impact on our current understanding of the mechanisms of tumorigenesis and the pathways regulated by cancer-related genes. These models hold the promise of serving as critical tools in the discovery and testing of novel therapeutics to be used in the treatment and prevention of cancer. The Transgenic Mouse Model Laboratory (TMML) provides assistance to the scientific community with the generation of genetically engineered mice (GEM), offering a complete array of services aimed at the successful generation of tran… [learn more]

The function of the SAIP is to collaborate with NCI investigators in the development of mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies utilizing in vivo imaging techniques. In addition, the SAIP collaborates with the NCI Division of Cancer Treatment and Diagnosis (DCTD) Nanotechnology Characterization Laboratory (NCL) to analyze nanoplatforms as part of the cascade assay and assist DCTD initiatives in developing standards in small animal imaging, integrate imaging into drug development, and develop partnersh… [learn more]

The function of the SAIP is to collaborate with NCI investigators in the development of mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies utilizing in vivo imaging techniques. In addition, the SAIP collaborates with the NCI Division of Cancer Treatment and Diagnosis (DCTD) Nanotechnology Characterization Laboratory (NCL) to analyze nanoplatforms as part of the cascade assay and assist DCTD initiatives in developing standards in small animal imaging, integrate imaging into drug development, and develop partnersh… [learn more]

Molecular Cytogenetics Core Facility facilitates the assessment of structural and numerical genomic changes in pre-cancer and cancer research models. This core provides comprehensive support for the cytogenetic analysis of cells from human and research animal sources. A wide range of chromosome analysis techniques are available; ranging from basic G-banded karyotyping, to 24-color Spectral Karyotyping (SKY), as well as Fluorescence in situ Hybridization (FISH) mapping of cloned DNAs. Services include: Karyotype characterization of new cell lines; human, mouse, and rat, Confirmation of … [learn more]

The research conducted within the Synthetic Biologics Core (SBC) Facility has a dual role: Generate chemical biology tools and drug candidates for molecular targets identified by NCI research groups, Develop novel effective methods and tools for more effective molecular discovery, Chemical biology tools for studying protein functions have many advantages over applications of genetic approaches for studying protein functions. However, wide use of chemical probes is hampered by the difficulties in their generation and characterization. Because the majority of cancer driver… [learn more]

The Biophysics Core’s mission is to provide support in the study of macromolecular interactions, dynamics, and stability by offering consultations, training, professional collaborations, and instrument access. General Services Multi-technique molecular interaction studies, Kinetic and thermodynamic characterization of interactions, Biophysical characterization of protein complexes and molecular assemblies, Biophysical characterization of integral membrane proteins, Characterization of exosomes, viruses and nanoparticles, Sample quality control and optimization, Stabili… [learn more]

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.Established TechnologiesCardiovascular Phenotyping, Metabolic Phenotyping, Pulmonary Phenotyping, Behavioral Phenotyping, Exercise Physiology, Echocardiography, In vivo functional vascular phenotyping, Advanced Imaging Modalities (whole body high frequency ultrasound imaging, vascular imaging), [learn more]

The NHLBI Murine Phenotyping Core carries out physiologic and behavioral testing in a diversity of mouse models for NHLBI and other NIH institutes.Established TechnologiesCardiovascular Phenotyping, Metabolic Phenotyping, Pulmonary Phenotyping, Behavioral Phenotyping, Exercise Physiology, Echocardiography, In vivo functional vascular phenotyping, Advanced Imaging Modalities (whole body high frequency ultrasound imaging, vascular imaging), [learn more]

The NHLBI Transgenic Core’s main mission is to keep up with the latest advancements in genome engineering technologies and to provide state-of-the-art services to assist NIH scientists in generating genetically engineered animal models. In the past several years, the Core has successfully used the ZFN, TALEN, and CRISPR methods to generate gene-targeted mouse lines. The revolutionary CRISPR technology has enabled the Core to simultaneously target multiple genomic loci and achieve gene knockout in difficult mouse strains, such as immunocompromised mice. Besides developing these new technologi… [learn more]

The NHLBI Transgenic Core’s main mission is to keep up with the latest advancements in genome engineering technologies and to provide state-of-the-art services to assist NIH scientists in generating genetically engineered animal models. In the past several years, the Core has successfully used the ZFN, TALEN, and CRISPR methods to generate gene-targeted mouse lines. The revolutionary CRISPR technology has enabled the Core to simultaneously target multiple genomic loci and achieve gene knockout in difficult mouse strains, such as immunocompromised mice. Besides developing these new technologi… [learn more]

The NIH Metabolomics Consortium (NIH-MC) is a shared research resource that performs metabolomics analysis (and related small molecule research) for investigators at all Institutes and Centers across the NIH Intramural Research Program. The NIH-MC is administered at NIEHS with participating laboratories at NIEHS, NIA, and NIAID. The NIH-MC was established in 2023 and continues to grow in the offerings provided, expertise, and participatory labs. Established Technologies Metabolomics measures the small molecules – endogenous and exogenous – that underpin biological changes in response to … [learn more]

The Magnetoencephalography (MEG) Core Facility specializes in MEG, a non-invasive procedure similar to electroencephalography (EEG), and aims to support research to better understand of the functioning of the brain. Established Technologies Magnetoencephalography (MEG) is a non-invasive procedure similar to electroencephalography (EEG) in terms of basic principles and analysis, however, MEG consists of sitting in a chair or lying on a bed while your head is inside a helmet shaped device which contains magnetic field sensors. These superconducting quantum interference device (SQUID) sensors … [learn more]

The Magnetoencephalography (MEG) Core Facility specializes in MEG, a non-invasive procedure similar to electroencephalography (EEG), and aims to support research to better understand of the functioning of the brain. Established Technologies Magnetoencephalography (MEG) is a non-invasive procedure similar to electroencephalography (EEG) in terms of basic principles and analysis, however, MEG consists of sitting in a chair or lying on a bed while your head is inside a helmet shaped device which contains magnetic field sensors. These superconducting quantum interference device (SQUID) sensors … [learn more]

Our mission is to help both scientists and non-scientists at the Frederick National Laboratory communicate more effectively. We aim to provide our customers with maximum convenience and unique value. Established Technologies Scientific Illustration SPGM illustrators are skilled in developing a wide variety of illustrations for journal publication or visual presentation in both video and still media. They can help you with the eye-catching visuals that journal editors and reviewers demand. Editing and Writing Services SPGM’s editorial staff reviews posters, scientific manuscripts, site… [learn more]

The centrally funded Statistics team within the Advanced Biomedical Computational Science group at the Frederick National Lab provides statistical consultation and data analysis support for NCI laboratories. We have broad-range expertise in biomedically relevant areas of applied and computational statistics, as well as related subjects. The team can help with both advanced and standard statistical analyses. These include data-sample comparisons (such as pairwise comparisons and ANOVA), linear or nonlinear regression, linear or nonlinear mixed-effects modeling, survival analysis, power and samp… [learn more]

The CCR Microscopy Core provides NCI investigators access to state-of-the-art imaging tools and techniques, including light sheet fluorescence, high-resolution confocal, multi-photon, and super-resolution microscopy. The mission of the CCR Microscopy Core Facility is to support the microscopy and digital imaging needs of investigators studying the biological structures and cellular processes involved in the cell biology of cancer by applying our diverse imaging resources, expertise, and quality customer service. The goal is to provide cutting-edge imaging technology, expert consultation and tr… [learn more]

The FNLCR Molecular Histopathology Laboratory (MHL) provides comprehensive veterinary pathology support for animal health monitoring, biomarker discovery and validation, drug development, genomics, and proteomics on a cost recovered basis. The MHL is organized into multiple process groups with cross-trained experts in animal study design, phenotyping of genetically engineered mice (GEM), immunopathology, anatomic pathology, toxicological pathology, and specimen classification/selection for tissue microarray (TMA) construction or laser capture microdissection (LCM). Established Technologies … [learn more]

The FNLCR Molecular Histopathology Laboratory (MHL) provides comprehensive veterinary pathology support for animal health monitoring, biomarker discovery and validation, drug development, genomics, and proteomics on a cost recovered basis. The MHL is organized into multiple process groups with cross-trained experts in animal study design, phenotyping of genetically engineered mice (GEM), immunopathology, anatomic pathology, toxicological pathology, and specimen classification/selection for tissue microarray (TMA) construction or laser capture microdissection (LCM). Established Technologies … [learn more]