Search Results for: breast cancer tma

The Biopharmaceutical Development Program (BDP) provides resources for the development of investigational biological agents. The BDP supports feasibility through development and Phase I/II cGMP manufacturing plus regulatory documentation. The BDP was established in 1993. We Read More...

The Clinical Image Processing Service (CIPS) offers timely and accurate advanced image processing of diagnostic radiology images for clinical care, research, and training. CIPS’ functions include clinical services and scientific researches. Established Technologies CIPS can Read More...

Our Mission The Office of Science and Technology Resources (OSTR) catalyzes the advancement of cancer research through making innovative technologies and scientific resources accessible to scientists at the Center for Cancer Research (CCR). OSTR develops Read More...

The COP evaluates novel therapies in pet dogs with cancer to improve outcomes for human patients and established the Comparative Oncology Trial Consortium (COTC), a collaborative effort of NCI and extramural comparative oncology centers at 24 Read More...

[embed]https://youtu.be/yTl1Q0D7aZ0[/embed] 10x Genomics' supports multiple cancer research areas from single nucleotide and structural variant detection to single cell whole transcriptome gene expression analysis of thousands of individual Read More...

NCI established the Nanotechnology Characterization Laboratory (NCL) to support the extramural research community to accelerate the progress of nanomedicine by providing preclinical characterization and safety testing of nanoparticles. It is a collaborative effort between NCI, Read More...

Discover expert help with analysis, processing applications, and licensed software packages.

The NCI Cloud Resources are components of the NCI Cancer Research Data Commons (CRDC) that bring data and computational power together to enable cancer research and discovery. These cloud-based platforms eliminate the need for researchers Read More...

We are a bioinformatics team within the Center for Biomedical Informatics and Information Technology’s (CBIIT’s) Cancer Informatics Branch (CIB)—soon to be referred to as the Informatics and Data Science (IDS) Program. Headed Read More...

Proteomic Data Common (PDC) represents the NCI’s largest public repository of proteogenomic comprehensive tumor datasets, essentially a Proteogenomic Cancer Atlas. It was developed to advance our understanding of how proteins help shape the risk, Read More...

Many established and emerging technologies are available to CCR scientists.  This technology-rich environment makes the CCR a unique place to conduct scientific research.  Through the OSTR, the CCR continues to find Read More...

The Office of Collaborative Biostatistics, Office of the Clinical Director, is the statistical and data management component of CCR. The Section provides statistical leadership and data management consultation for CCR’s major clinical activities and Read More...

The Blood Processing Core monitors viral load in patients with HIV and performs sequential studies using samples obtained from patients with cancer, AIDS, chronic granulomatous disease, or other diseases associated with immunologic dysfunction. The core Read More...

October 6, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

NCI maintains a low temperature repository of implantable in vivo-derived tumors and in vitro-established tumor cell lines from various species, which are available to qualified investigators as a service to the cancer research community. The Read More...

September 8, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

The BRB Preclinical Biologics Repository is a central repository that supplies reagents to the broad research community. This NCI-sponsored repository is managed by NCI's Biological Resources Branch (BRB) in the Development Therapeutics Program (DTP) of Read More...

Radiation Oncology Branch is part of CCR. Bioinformatics core is a collaborative resource to support ROB branch and provide service to ROB investigators from NCI and other Institutes access to new technologies, bioinformatics, statistical analysis Read More...

The goals of the Bioinformatics Training and Education Program within NCI/CCR are: To make researchers aware of the bioinformatics resources available to them, To provide training and guidance on these resources regularly and at Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx NIH NeuroBioBank (NBB) The NBB provides researchers with access to human post-mortem brain tissue Read More...

The CCR Microscopy Core provides NCI investigators access to state-of-the-art imaging tools and techniques, including light sheet fluorescence, high-resolution confocal, multi-photon, and super-resolution microscopy. The mission of the CCR Microscopy Core Facility is to support Read More...

CREx News & Updates June 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Visit here to learn about services from Read More...

The Antibody Characterization Laboratory (ACL) is the laboratory responsible for the development of well-characterized monoclonal antibody reagents. The NCI’s Office of Cancer Clinical Proteomics Research funds ACL as a resource to the entire cancer Read More...

The Mass Cytometry Core (MCC) provides access to cutting-edge platforms and expert technical support for high-dimensional single-cell analysis and spatial proteomic profiling. A central expertise of the core is Imaging Mass Cytometry (IMC), which allows Read More...

The Crystallization Facility provides an automated environment for setting up crystallization experiments in a high-throughput format, storing the resulting plates under controlled conditions, and monitoring the status of prepared droplets remotely. The Facility is in Read More...

CCR Office of Science and Technology Resources (OSTR) The Center for Cancer Research (CCR) Office of Science and Technology Resources (OSTR) explores and evaluates the latest technologic advancements and then makes them available to all Read More...

The Antibody Engineering Program (AEP) is located at the Laboratory of Molecular Biology, which is part of the Center for Cancer Research (CCR), an intramural program at the National Cancer Institute (NCI). AEP focuses on Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx Program Manager The CREx Team is happy to announce Deepika Velampati as the new CREx Program Read More...

Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.

Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Intramural Core Resources NHGRI Flow Cytometry Core The Core performs high quality single cell analysis through the Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New CREx User Survey The CREx Team is carrying out a CREx User Survey. We would greatly appreciate Read More...

The National Cancer Institute (NCI) is developing a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), patient-derived organoids (PDOrg), and in vitro patient-derived tumor cell cultures (PDCs) and cancer-associated fibroblasts (CAFs). These Read More...

The NCI Genomic Data Commons (GDC) was established by the NCI Center for Cancer Genomics (CCG) to support the receipt, harmonization, distribution, and analysis of genomic and clinical data from cancer research programs. The GDC Read More...

Discover expert help with analysis, processing applications, and licensed software packages.

CREx News & Updates January 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NCI ANTIBODY CHARACTERIZATION LABORATORY (ACL) The ACL specializes in rigorously validating antibodies for signaling and Read More...

Discover expert help with analysis, processing applications, and licensed software packages.

Our mission is to help both scientists and non-scientists at the Frederick National Laboratory communicate more effectively. We aim to provide our customers with maximum convenience and unique value. Established Technologies Scientific Illustration SPGM illustrators Read More...

Discover expert help with analysis, processing applications, and licensed software packages.

The Molecular Targets Program (MTP) is an organizational entity within the Center for Cancer Research (CCR) at NCI. The MTP provides the focus and infrastructure to enable CCR tenured and tenure-track Principal Investigators to initiate Read More...

Discover expert help with analysis, processing applications, and licensed software packages.

CREx News & Updates August 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...

DTP maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. The Repository collection is a uniquely diverse set of more than 200,000 compounds that have been Read More...

The Genomics and Pharmacology Facility is part of the NCI's Center for Cancer Research (CCR), within the Developmental Therapeutics Branch. Its mission is to manage and assess molecular interaction data obtained through multiple platforms, increase Read More...

Employing spatial biology techniques enables acquisition of transcript and protein data from intact tissue sections, and in turn, spatial distribution information and cellular interaction patterns are revealed.

The Frederick Sequencing and Genomics Core (FSGC) was established through the integration and consolidation of the former Sequencing Facility (SF) and the Genomics Technology Laboratory (GTL). The new FSGC eliminates redundancy and provides cutting edge Read More...

The function of the SAIP is to collaborate with NCI investigators in the development of mouse models, new molecular imaging probes for early detection and therapy, monitor tumors in vivo, and perform drug efficacy studies Read More...

The NMR Facility for Biological Research operates six NMR spectrometers with proton resonance frequencies from 850 to 500 MHz. Three of the highest field spectrometers (850, 700, 600) are equipped with higher sensitivity cryoprobes optimized for high-resolution multi-dimensional and relaxation Read More...

The rapid advancement of single-cell technology has provided new powerful tools to answer many biological questions, such as identifying new or rare cell populations and characterizing the complexities of tumor heterogeneity. Realizing the great potential Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Advance your research with the NIH Mouse Imaging Facility (MIF) The NIH Mouse Imaging Read More...

The Antibody Engineering Program (AEP) is part of the Center for Cancer Research (CCR) at the National Cancer Institute (NCI). The program focuses on generating therapeutic antibodies by phage display technology, including human antibodies and Read More...

NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of protein, macromolecular complexes, membrane receptors, cellular organelles, and Read More...

The Laboratory Animal Sciences Program (LASP) of the Frederick National Laboratory operates a Gnotobiotics Facility (GF) to support research focused on the role of microbiota in cancer inflammation, pathogenesis, and treatment response. The GF can Read More...

The Pharmacogenetics Core is responsible for correlating outcome observations (toxicity, efficacy, survival, PK/PD) with genetic variants (germline or somatic) to identify key genetic determinants and biomarkers that predict response to specific treatments. We also Read More...

The Medicinal Chemistry Accelerator (MCA) is a collaborative CCR resource that supports investigators in developing small molecule inhibitors for anticancer drug candidates. While CCR and NCATS have infrastructure to identify initial “hits” through high-throughput screening, Read More...

The CCR Molecular Modeling Core, under the direction of Dr. Stewart Durell, was established to provide a convenient way for experimentalists to take advantage of molecular modeling and computational biology. In the framework of consultations, Read More...

Molecular Cytogenetics Core Facility facilitates the assessment of structural and numerical genomic changes in pre-cancer and cancer research models. This core provides comprehensive support for the cytogenetic analysis of cells from human and research animal Read More...

The Behavioral Health Core (BHC) is comprised of the two separate but interrelated components: Psychosocial Support and Research Program, and, Health Psychology and Neurobehavioral Research Program., These teams provide specialized expertise, such as patient-reported and Read More...

CREx News & Updates October 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGLIGHTS Learn more about services from the CPTR Read More...

The Center of Cellular Engineering (CCE) is a comprehensive facility that develops and manufactures a wide range of cell and gene therapies for early phase clinical trials. The CCE is currently manufacturing chimeric antigen receptor ( Read More...

CREx News & Updates July 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...

The CCR Building 41 Flow Cytometry Core is a full-service facility within the Center for Cancer Research that supports over 150 users representing 26 laboratories. The Core Facility provides instrument and software training, technical expertise, assay development, and Read More...

Mouse models of human cancer have had a profound impact on our current understanding of the mechanisms of tumorigenesis and the pathways regulated by cancer-related genes. These models hold the promise of serving as critical Read More...

The CCR Animal Resource Program (ARP) plans, develops, and coordinates laboratory animal resources for CCR’s research programs. We also provide training, imaging, and technology development in support of moving basic discoveries to the clinic. Read More...

The NCI Research Flow Facility provides cell sorting and benchtop flow cytometry services to NCI investigators. Services are program-specific and are not available to all NCI or NIH investigators. Please inquire as to availability. Established Read More...

Our operational objectives are to provide state-of-the-art OMICS technologies in support of the Genetics Branch (GB) investigators and collaborators. Research Services Wet Lab Single cell isolation from fresh, frozen, and FFPE tissue, DNA/RNA extractions Read More...

Bruker AVANCE 400 and 500 MHz NMR instruments. Helium Cryoprobe technology on the 500 MHz machine for added sensitivity, especially for Carbon-13 spectra. Access to a second 500 MHz instrument with Prodigy Liquid Nitrogen-cooled cryoprobe. User Accounts can be Read More...

The research conducted within the Synthetic Biologics Core (SBC) Facility has a dual role: Generate chemical biology tools and drug candidates for molecular targets identified by NCI research groups, Develop novel effective methods and tools Read More...

CREx News & Updates September 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGLIGHTS Learn more about services from the CCR Read More...

The CCR Genomics Core is located in Building 41 on the NIH Bethesda campus. The primary goal of the Core is to provide investigators from CCR/NCI and other NIH Institutes access to genomic technologies and Read More...

CREx News & Updates November 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the NINDS Quantitative Magnetic Resonance Imaging Core. NINDS Read More...

Thousands of molecular targets have been measured in the NCI panel of 60 human tumor cell lines. Measurements include protein levels, RNA measurements, mutation status, and enzyme activity levels. You can choose to search for a Read More...

CREx News & Updates February 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight ORS Division of Veterinary Resources (DVR) DVR is the central NIH lab animal support program Read More...

LCMB Microscopy Core offers live cell imaging technologies as well as super-resolution, fluorescence lifetime and confocal imaging systems for immunofluorescence. Our confocal instruments are a Leica SP8 laser scanning confocal microscope and a Nikon spinning Read More...

The CPP is directly responsible for the pharmacokinetic (PK) analysis of numerous Phase I and II clinical trials conducted within the NCI. In addition, the CPP provides direct PK support for many studies performed elsewhere Read More...

The Animal Diagnostic Laboratory (ADL) provides a full range of diagnostic capabilities, including microbiological cultures on various culture medium, microscopic screening for parasites such as mites and pinworms, molecular detection of pathogens, serological evaluation of Read More...

The Chemical Synthesis Group is a component of the Chemical Biology Laboratory. This facility provides synthetic chemistry resources and expertise to the NCI Intramural community.The facility’s capabilities include: Providing expertise, consultation, and experience Read More...

CREx News & Updates March 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight NIA Nonhuman Primate Core The NIA Nonhuman Primate Core supports multi-disciplinary translational aging projects for Read More...

The Electron Microscopy Core (EMC), formerly known as Electron Microscopy Lab (EML),  offers investigators access to unique expertise and EM technologies that allow CCR Investigators to explore new avenues of research in order to enhance Read More...

CREx News & Updates December 2021 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Site Spotlight FACILITY HIGLIGHTS Learn more about services from the STRIDES Initiative. VIEW STRIDES INITIATIVE NIH Cores Read More...

The Center for Inherited Disease Research (CIDR)'s  mission is to support the genetics community by providing high-quality, cutting-edge genomics services and technologies in order to expand our understanding of disease and catalyze discoveries that Read More...

CLIA-Certified Technologies Offered: Fragment Analysis for Micro-satellite Instability Detection, Pharmacoscan Array for Pharmacogenomics, Mutation Detection for PCR and Sanger Sequencing, DNA extraction from whole blood, saliva, FFPE tissues, buccal swabs, nails, hair, PBMCs, buffy coats, Read More...

The Molecular Pathology Unit is intended to spearhead opportunities for bridging basic and clinical research efforts by more precisely optimizing the development, characterization, and utilization of models of human disease. The initiative approach includes both Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New Resources on CREx Interested in imaging large scale biological samples?  Volume electron microscopy allows for Read More...

NCI LASP Genome Modification Core (GMC) is a CCR-dedicated facility that provides advice, training, and reagents to NCI scientists seeking to utilize CRISPR and other nucleases to generate genome modifications in primary cells, cell lines, Read More...

Clinical Support Laboratory – Flow Cytometry Section is a laboratory specializing in providing immunophenotyping support of NCI intramural clinical trials, though assessments may also be performed using cells from Non-human primates and other species. The CSL Read More...

The Clinical Flow Cytometry Laboratory provides extensive support for NCI clinical protocols by providing diagnostic testing for leukemia and lymphoma in patients either on NCI clinical protocols or undergoing testing to determine eligibility for NCI Read More...

The Metabolic Clinical Research Unit (MCRU) opened in 2007 as a key component of the Strategic Plan for NIH Obesity Research . The NIDDK worked closely with the Clinical Center to design the Unit, which houses state-of-the-art Read More...

Mass Spectrometry Section of the Collaborative Protein Technology Resource (Bldg. 37) Core Capabilities: Identification of proteins in complexes, organelles, subcellular fractions, or fluids. Global relative protein quantitation. Quantitation by isotopic labeling of cells in culture (SILAC) Read More...

The NCI Clinical Research Correlatives Core provides non-CLIA-certified spectral flow cytometric assays to support clinical trials conducted in the CCR. The core specializes in immunophenotyping and immune monitoring assays. Established Technologies Spectral flow cytometry (Cytek), Read More...

The Spatial Imaging Technology Resource (formerly the Nanoscale Protein Analysis Section of the Collaborative Protein Technology Resource or CPTR) provides expertise and service in state-of-the-art protein analysis technologies to advance CCR research in basic discovery Read More...

In order to meet increasing demands from both NIH intramural and extramural communities for access to a small angle X-ray scattering (SAXS) resource, the Center for Cancer Research (CCR) under the leadership of Drs. Jeffrey Read More...

The primary objective of the Protein Technology Core (PTC) is to establish an experimental screening pipeline for single-domain antibodies termed nanobodies. Nanobodies are antibody fragments consisting of a single monomeric variable antibody domain. The PTC, Read More...

DTP’s Natural Products Repository is the world’s largest storehouse of natural products. It houses close to >200,000 extracts from samples of more than 70,000 plants and >20,000 marine organisms collected from more than 29 countries, plus extracts Read More...

Clinical Support Laboratory – Cellular Immunology offers a spectrum of bioassays to assess cellular responses to antigens and mitogens including ELISPOT, cytotoxicity assays, and proliferation assays. Established Technologies Elispot Assays, Dual or Triple Color Fluorospot Assays, Read More...

September 8, 2022 crex.nih.gov CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Science & Technology Seminars and Training Events Upcoming Seminars and Educational Opportunities The following Read More...

CCR VOLUME Electron Microscopy Core (CVEMC),  formerly known as volume Electron Microscopy (vEM), aims to develop new techniques in volume electron microscopy (vEM) and, in collaboration with CCR Investigators, apply these techniques to research cell Read More...

The Advanced Biomedical Computational Sciences (ABCS) group provides technology development, scientific consultation, collaboration and training, research, software development, and high-performance computing support. ABCS encompasses specialized groups focusing on machine learning applied to the interpretation of 2 Read More...

The Central Repository provides the research community at the NCI with various cryogenic services, including low-temperature storage from +4° C to -196° C, controlled-rate freezing, computerized inventory and distribution of samples. The Central Repository is operated Read More...

NCI LASP Animal Research Technology Support (ARTS) provides customized technical support for basic and translational animal-based research to the scientific community. We offer a wide array of services ranging from expert colony management to the Read More...

The centrally funded Statistics team within the Advanced Biomedical Computational Science group at the Frederick National Lab provides statistical consultation and data analysis support for NCI laboratories. We have broad-range expertise in biomedically relevant areas Read More...

.row { display: flex; justify-content: space-around; align-items: flex-start; margin: 20px; } .column { text-align: center; padding: 10px; width: 30%; } .column img { display: block; margin: 0 auto; width: 150px; height: 150px; } .column strong { display: block; margin-top: 10px; } Background: Intravital microscopy (IVM) Read More...

The Mass Spectrometry Unit of the Collaborative Protein Technology Resource uses mass spectrometry for the study of proteins. We perform collaborative experiments with CCR researchers in areas such as: interactomes, quantitative global proteome analyses, and Read More...

Cores & Facilities From centralized laboratories to collaborative resources and technologies available to CCR Investigators. NCI Cores Centralized laboratories providing broad access to cutting-edge technologies and specialized expertise. Browse NCI Cores Collaborative Resources are technologies and Read More...

The Biophysics Resource (BR) was established in January 2001. Our mission is to provide CCR investigators with access to both the latest instrumentation and expertise in characterizing the biophysical aspects of systems under structural investigation. The Read More...

As a multi-user facility, the different instruments provide a wide range of imaging modes for EIB scientists, from standard immunohistochemistry, through brightfield and wide-field epifluorescence imaging, to highly complex live cell confocal microscopy and super-resolution Read More...

The CCR-Frederick Flow Cytometry Core Facility provides research support to the Frederick-CCR community, including cytometry analysis and sorting services, instrument maintenance, new user training, and technical consultation. Typical Assays Performed by Core Instruments Immunophenotyping of Read More...

The PET Department, CC, functions as a core facility that supports basic, translational, and clinical research using PET. It is a vertically integrated facility, with resources to produce positron-emitting radionuclides, manufacture PET radiopharmaceuticals in a Read More...

The Clinical Support Laboratory offers processing, tracking, and testing of a broad range of clinical samples. Support can begin at the early stages of clinical trial development to aid in developing a comprehensive strategy for Read More...

The PPS encompasses all scientific analyses related to pharmacology, once the specimen has been collected and stored. There is a multi-step process to evaluate how the drug is being handled by the body after administration. Read More...

What is Visium FFPE v2 with CytAssist? Visium FFPE v2 is sequencing-based spatial profiling technology developed by 10x Genomics. This assay can take mouse or human tissue sections on normal glass slides as input and Read More...

CREx News & Updates July 2021   Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Collaborative Research Exchange (CREx) News Site Spotlight FACILITY HIGHLIGHTS Learn more about services from the NHLBI Read More...

The core provides access to several different state-of-the-art 3D microscopes as well as computers to visualize and process image data. The facility houses equipment for 2D or 3D imaging of fixed and living specimens. High Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Resources Derive Greater Insights and Accelerate your Research Using Bioinformatic Tools! CREx is an NIH Read More...

The Optical Microscopy Analysis Core (OMAC), formerly known as the Optical Microscopy Analysis Lab (OMAL),  focuses its research and development activities to quantitatively understand the molecular basis of three-dimensional (3D) cell organization, motility, invasion, and Read More...

The NCI High-Throughput Imaging Facility (HiTIF) works in a collaborative fashion with NCI/NIH Investigators by providing them with the necessary expertise, instrumentation, and software to develop and execute advanced High-Throughput Imaging (HTI) assays. These Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More NIH Research Festival The NIH Research Festival highlights the groundbreaking science and the vibrant NIH community driving our Read More...

The CCR Collaborative Bioinformatics Resource (CCBR) is a centrally funded resource group which provides a mechanism for CCR researchers to obtain many different types of bioinformatics assistance to further their research goals. The group has Read More...

CREx Monthly Newsletter Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More New NIH Resource Spotlight The NIH Lab Managers Working Group have developed a new NIH-wide database of cold Read More...

The Division of Veterinary Resources Animal Surgery has supported large animal research and clinical care for more than 40 years. DVR surgeons provide outstanding and highly specialized large animal (rabbits, ungulates, etc.) research support in a Read More...

CREx News & Updates April 2022 Learn about the NIH Collaborative Research Exchange (CREx), Core Facilities, Webinars, & More Click below to learn how easy it is to navigate the CREx platform. These short videos will Read More...

The Flow Cytometry Core (LGI) offers established technologies to support studies using flow cytometry and cell sorting. Established Technologies Applications that run on FACS Caliburs include: Immunophenotyping (up to 4-color), Intracellular markers, including cytokines and Read More...

The Biophysics Core’s mission is to provide support in the study of macromolecular interactions, dynamics, and stability by offering consultations, training, professional collaborations, and instrument access. General Services Multi-technique molecular interaction studies, Kinetic and Read More...

Protein and Metabolite Characterization Core (PMCC), formerly known as the Protein Characterization Lab (PCL),  offers various technologies to CCR investigators to characterize proteins and metabolites. The core develops and applies state-of-the-art analytical technologies, primarily mass Read More...

The Chemistry and Synthesis Center (CSC) of the National Heart, Lung, and Blood Institute (NHLBI) provides IRP scientists with targeted imaging probes and chemical tools that help accelerate cell-based assays, in vivo imaging studies, and Read More...

[tabby title="Home"] About NICE-NIH Intramural CryoEM Consortium  NIH Intramural CryoEM Consortium (NICE) serves intramural investigators in all NIH IC’s. NICE provides access to state-of-the-art Titan Krios cryo-electron microscopes for atomic-resolution structure determination of Read More...

The OSTR offers cutting-edge technology platforms to the CCR scientific community through centralized facilities. The videos accessed through this page are designed to introduce the various scientific methodologies OSTR makes available through the cores on Read More...

03/25/2025 - Agreement Across 10 Artificial Intelligence Models in Assessing HER2 in Breast Cancer Whole Slide Images: Findings from the Friends of Cancer Research Digital PATH Project For more information, please contact Aniruddha Ganguly, Ph.D.

07/14/2022 - The efforts of our laboratory are split evenly between experimental and computational biology.  We develop new experimental methods to sequence single cells and isolate rare subpopulations and develop new analytical approaches to detect variants Read More...

05/07/2025 - Join Dr. Eytan Ruppin, NCI investigator in the Center for Cancer Research, as he discusses Path2Space, a new and unpublished deep learning approach that predicts spatial gene expression directly from histopathology slides. Spatial Read More...

10/20/2025 - AI-Driven Spatial Transcriptomics Unlocks Large-Scale Breast Cancer Biomarker Discovery from Histopathology

07/14/2022 - Nicholas Navin, Ph.D. Professor, Department of Genetics, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center Grady F. Saunders, Ph.D. Distinguished Professorship for Molecular Biology, Department of Genetics, Read More...

04/20/2021 - Register Here Description: Dr. Nicholas Navin is an Associate Professor at MD Anderson Cancer Center, with a joint appointment in the Department of Bioinformatics. He is a faculty member at The University of Texas Read More...

04/07/2022 - Join Dr. Maryellen L. Giger at the April NCI Imaging and Informatics Community Webinar for a discussion on the development, validation,  database  needs, and ultimate future implementation of artificial intelligence (AI) in the clinical Read More...

04/28/2021 - Register/Join This month’s Cancer Genomics Cloud (CGC) webinar welcomes two bioinformaticians, Dr. Vesna Pajic and Nevena Vukojicic, to show attendees how CGC features can be used to perform multi-omics analysis. Dr. Pajic Read More...

01/22/2025 - Join us for a one-hour talk investigating tumor signatures in the BRCA dataset by utilizing the CCBR Single-Cell RNA-seq Workflow on NIDAP. This talk will take you through an analysis of a publicly available Read More...

12/06/2021 - Researchers have identified potential biomarkers, representing both biological and social factors, that can impact cancer incidence and care outcomes. Those biomarkers are being gleaned from a wide variety of data in the  Cancer Research Read More...

03/17/2021 - Register/Join The focus of this webinar will be on two aspects of integrative analysis and translational research in the field of estrogen receptor-positive (ER+) breast cancer research. Namely, Dr. Meenakshi Anurag will discuss Read More...

01/27/2026 - The SeqSPACE Planning Committee is pleased to announce the second webinar of our two-part webinar series highlighting the work of four junior investigators selected through our recent call for abstracts. Part 2 will feature presentations Read More...

06/15/2022 - During this seminar, Washington University in St. Louis’ Dr. Obi L. Griffith will present  CIViC : an  open access , open source, community-driven web resource for clinical interpretation of variants in cancer. The goal of this Read More...

11/16/2020 - Register Cancer heterogeneity is one of the major challenges that hampers the ability to cure the disease. Tumors differ in their genetic profiles and the cellular interactions in the microenvironment, and each tumor may Read More...

11/19/2019 - Methods for Characterizing the Activity of Mutational Processes in Cancer The cancer sequencing efforts of the past decade have revealed signatures of the mutational processes shaping cancer genomes. These mutational signatures provide a window Read More...

01/28/2026 - Navigating Risk in Sharing Cancer Data: Sharing cancer data accelerates scientific discovery and promotes innovation across disciplines, which brings complex ethical, legal, and procedural challenges. This panel will share practical experiences; current Read More...

06/16/2025 - In 2017, Dr. Rol joined the World Health Organization' International Agency for Re earch on Cancer (IARC-WHO), motivated to improve equal acce to high-quality healthcare for everyone. Currently, he lead an IARC team dedicated to Read More...

05/27/2025 - Agentic AI is a class of artificial intelligence that acts autonomously to make decisions and take actions to achieve specific goals. During this event, the participants will discuss the emerging role of AI agents Read More...

08/10/2022 - For our next CDSL webinar we will have two fellows’ talks from Dr. Zisha Zhong and Arati Rajeevan . Zisha’s talk details: Title:  Multi-task Feature Learning to train Interpretable Encoders on Histopathology Images Digital Read More...

04/07/2021 - Register/Join Researchers continue to face major challenges when comparing diverse single-cell RNA sequencing (scRNA-seq) data sets, because these data often are generated by different technologies from a variety of laboratories. In this webinar, Read More...

The data used are located in /data/classes/BTEP/hcc1395_b4b on Biowulf. This data was obtained from rnabio.org and essentially a transcriptomic profiling study comparing between tumor and normal HCC1395 breast cancer Read More...

01/16/2026 - Part of the Childhood Cancer Data Initiative (CCDI) Webinar Series During this webinar, experts from the USC Norris Comprehensive Cancer Center (NCCC) and Children's Hospital Los Angeles (CHLA) will present: An overview of Read More...

12/11/2025 - If you’re interested in learning how machine learning can help you tap into the rich data within electronic health records, join us to learn more about the “Memorial Sloan Read More...

12/02/2025 - The SeqSPACE Planning Committee is pleased to announce a two-part webinar series highlighting the work of four junior investigators selected through our recent call for abstracts. Part 1 will feature presentations by Dr. Jing Dong Read More...

12/02/2025 - If you are looking for computational tools for your cancer research, join us for this upcoming training session on Galaxy, an open-source and browser-based computational platform. Dr. Jeremy Goecks, an NCI grantee and Assistant Read More...

09/29/2025 - Plea e u e thi link to acce overview, regi tration, and other information: http ://event .cancer.gov/nci/od -data-jamboree Childhood cancer i a rare di ea e with ~15,000 ca e diagno ed Read More...

09/23/2025 - Dr. Church's clinical and research work focus on bringing molecular testing to the clinical care of children with cancer. Through institutional projects (the Profile study, GAIN consortium study) she has profiled thousands of Read More...

07/21/2025 - Profe or Angela Brook i a leader in the development and application of high-throughput genomic and computational approache to inve tigate gene regulation. Her re earch focu e on characterizing mutation impacting RNA expre Read More...

06/17/2025 - In thi webinar, Dr . Weng and Abdennur will be pre enting on the integrative analy i and vi ualization platform for cancer regulatory genomic .

05/20/2025 - In this talk, Dr. Hwang will discuss three examples of applying single-cell and spatial oncology approaches to the study of pancreatic cancer. First, he will explain how they utilized single-nucleus RNA-sequencing to uncover an Read More...

05/05/2025 - Insights from Scaled-up Cancer Tissue Proteomics

05/01/2025 - Integrating Mouse Models and Bioinformatics to Decode Cancer Progression

10/03/2023 - Presented as part of the Sequencing Strategies for Population and Cancer Epidemiology Studies (SeqSPACE) Webinar Series Dr. Kushal Dey is an Assistant Member and Josie Robertson Investigator in the Department of Computational and Systems Read More...

To help us apply what we learned during the lesson, we are going to use DAVID to obtain some functional annotation information on upregulated genes in the HCC1395 dataset. Recall that the HCC1395 dataset is Read More...

12/01/2021 - Speaker: James Lacey, Ph.D., M.P.H. Dr. James Lacey is a City of Hope professor and director of the Division of Health Analytics within the Department of Computational and Quantitative Medicine. His Read More...

05/19/2021 - Register Kinase inhibitors have been intensively studied and used effectively for cancer treatment for decades. Yet, despite our progress in understanding kinases in oncology, more needs to be known to better predict how and Read More...

05/19/2021 - Register/Join Kinase inhibitors have been intensively studied and used effectively for cancer treatment for decades. Yet, despite our progress in understanding kinases in oncology, more needs to be known to better predict how Read More...

03/24/2026 - Overview This 3-day, virtual workshop will explore how foundation models —a powerful class of advanced  AI models  —can transform cancer research and clinical care. We will Read More...

01/16/2026 - Speakers: James Amatruda, M.D., Ph.D. David Buckley, Ph.D. Jennifer Cotter, M.D. Alexander Markowitz, Ph.D. Moderator: Warren Kibbe, Ph.D., FACMI During this webinar, experts from the USC Norris Comprehensive Read More...

09/15/2025 - Since 2016, NCI and the U.S. Department of Energy (DOE) have engaged in a strategic, interagency collaboration to simultaneously accelerate advances in precision oncology and scientific computing, including the use of artificial intelligence. The Read More...

06/25/2025 - Join tony Brook Univer ity&r quo; Dr. Joel altz a he di cu e : the role of pathology artificial intelligence (AI) in the creation of pathology imaging biomarker , including tumor infiltrating lymphocyte Read More...

06/11/2025 - Join Dr. Dougla Flora, executive medical director of Oncology ervice at t. Elizabeth Healthcare, to explore how artificial intelligence (AI) i revolutionizing cancer care through oncology. Thi event will cover: &nb p; key Read More...

05/29/2025 - Prostate cancer exhibits significant intratumoral heterogeneity, driving a spectrum of phenotypes ranging from indolent disease to aggressive metastasis, challenging risk stratification and treatment. A key feature of this heterogeneity is clonal diversity, encompassing both Read More...

07/09/2025 - This session of the BTEP Coding Club will demonstrate the use of R programming to perform decision tree analysis, survival tree analysis, and random forest. This event complements a Statistics for Lunch event, " Read More...

05/06/2024 - Have you been looking for ways to use artificial intelligence (AI) in clinical practice but not sure where to start? Attend this webinar for tips from Dr. Anant Madabhushi on applying AI in precision Read More...

We are using the datasets below in the Qiagen IPA course. Human Brain Reference (HBR) and Univeral Human Reference (UHR) dataset Using this for the one hour lecture (from 1 - 2 pm) Find more information about Read More...

12/03/2021 - *** This seminar is open to the public, but registration is required. Recent genomic and imaging technologies that measure features at the resolution of single cells present exciting opportunities to characterize diverse immune cell states Read More...

05/13/2021 - Meeting Link The slides and recording of the webinar will be available within a day of the event. Heterogeneity poses a major challenge in translational research. For example, inter-tumor heterogeneity limits the biomarker discovery Read More...

07/07/2020 - In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative biomarkers that can Read More...

07/07/2020 - In systems biology, inference of functional associations among genes is compelling because the construction of functional association networks facilitates biomarker discovery. Specifically, such gene associations in human can help identify putative biomarkers that can Read More...

In this session of the BTEP Coding Club, Brian Luke, PhD, Senior Principal Computational Scientist with the Advanced Biomedical Computational Science (ABCS) group, demonstrated the use of R programming to perform decision tree analysis, survival Read More...

Navigate to the GDC Data Portal at https://portal.gdc.cancer.gov/ To select your cases of interest, you can navigate to "Projects" or "Cohort Builder" Let's use breast cancer Read More...

01/27/2026 - A discussion examining the opportunities, risks, and real-world considerations of using generative AI in healthcare delivery.

01/14/2026 - During this event, Dr. Emilie Roncali, an associate professor at UC Davis, is tackling an intersection of two critical data science concepts in cancer research: theranostics and digital twins. Dr. Roncali will give you Read More...

12/10/2025 - Join us as poster presenters from the ODS Symposium showcase innovative work that highlights powerful resources, inspiring examples, and the far-reaching impact of data sharing and reuse. Moderators: Ying Huang and Mousumi Read More...

07/22/2025 - Con ideration for protecting private data when training AI model i a topic of increa ing concern. During thi event, participant will di cu the u e of ynthetic data for privacy-pre erving AI.

Database for Annotation, Visualization and Integrated Discovery (DAVID) - practicing what we learned Learning objectives In this practice session, we will practice using DAVID. Practicing what we learned To help us apply what we learned Read More...

This data set is from the Griffith lab RNA sequencing tutorial and are kept at http://genomedata.org/rnaseq-tutorial/practical.tar. This dataset is derived from a study that profiled the transcriptome of HCC1395 breast Read More...

11/19/2021 - High-resolution, whole-brain microscopy provides unprecedented new insights into the brain’s structural organization, molecular diversity and connectivity. The Brain Image Library (BIL) provides infrastructure that facilitates the sharing of this valuable data, enabling investigators Read More...

05/03/2021 - Abstract: We will discuss technical advantages of a personalized and tumor-informed multiplex PCR next generation sequencing assay, called Signatera™, that enables a sensitive, specific, and dynamic detection of molecular disease burden in cell-free DNA ( Read More...

04/07/2021 - Dr. Wang will present virtually. Register now and join us via Webex. Researchers continue to face major challenges when comparing diverse single-cell RNA sequencing (scRNA-seq) data sets, because these data often are generated by Read More...

12/19/2016 - iPathwayGuide is a gene and protein expression analysis tool that uses a systems biology approach to identify significantly impacted pathways, gene ontology terms, diseases, and predicted microRNAs based on the given gene or protein Read More...

10/27/2014 - PLEASE NOTE: This 2 day workshop is  a BYOC (Bring your own Laptop Computer) class. In order to provide more flexibility with room scheduling we are experimenting with a new format that involves students brining Read More...

03/18/2014 - The Cancer Genome Atlas (TCGA) is a large-scale study that has catalogued genomic data accumulated from more than 20 different types of cancer including mutations, copy number variation, mRNA and miRNA gene expression, and DNA Read More...

Tasks to do at the Analysis Wizard: Provide an input gene list (either copy paste or upload as a text file) Specify the gene identifier type. Gene identifiers can be gene symbol, Ensembl IDs, Entrez Read More...

03/19/2026 - In this talk, Dr. Carey will describe how Bioconductor approaches new challenges in supporting open method development and reproducible analyses in genomic data science. He will discuss aspects of the project that bear on Read More...

2025 Sebastian R, Sun EG, Fedkenheuer M, Fu H, Jung S, Thakur BL, Redon CE, Pegoraro G, Tran AD, Gross JM, Mosavarpour S, Kusi NA, Ray A, Dhall A, Pongor LS, Casellas R, Aladjem MI. Mechanism Read More...

Lesson 12 Practice Objectives In this practice session, we will work with something new, which is a dataset from the Griffith lab RNA sequencing tutorial. Here, we will have a chance to practice what we have Read More...

09/01/2016 - This 2-day workshop, including a BYOD (Bring Your Own Data) exercise, will provide an introduction and hands-on training for Cytoscape, which is an open source software platform for visualizing  networks and integrating these networks Read More...

ggpubr allows us to easily incorporate additional information into our plots (e.g., mean, individual case information, etc.). Where this package really shines is its ability to easily include the results of common statistical tests. Read More...

04/06/2026 - Qlucore Omics Explorer is a desktop-based point-and-click software with built-in machine learning capabilities. It enables RNA sequencing (bulk and single cell), proteomics and metabolomics analysis. This software is available for NCI CCR scientists upon Read More...

03/02/2026 - Qlucore Omics Explorer is a desktop-based point-and-click software with built-in machine learning capabilities. It enables RNA sequencing (bulk and single cell), proteomics and metabolomics analysis. This software is available for NCI CCR scientists upon Read More...

01/29/2026 - In the final class of the Statistical Analysis of Research Data (SARD) series offered by NCI Center for Cancer Training participants will learn about: Multivariant data analysis Regression Non-parametric tools Goodness of fit tests Read More...

01/27/2026 - This is the third class of the Statistical Analysis of Research Data (SARD) series offered by NCI Center for Cancer Training. Here, participants will learn about: Bivariate statistics Linear regression Regression diagnostics This class Read More...

01/27/2026 - Join the NCI Cohort Consortium for a webinar on innovative approaches to improving data interoperability across cohort studies. The session will highlight efforts to apply the Observational Medical Outcomes Partnership Common Data Model to Read More...

01/23/2026 - In the second class of Statistical Analysis of Research Data (SARD) hosted by NCI Center for Cancer Training, participants will learn about: Inferential statistics Two sample tests of means Small versus large sample consideration Read More...

01/23/2026 - This is the second class of the Statistical Analysis of Research Data (SARD) series offered by NCI Center for Cancer Training. In this class participants will learn about: Inferential statistics  Two sample Read More...

01/22/2026 - Attend this webinar to learn more about XNAT Scout—a new extension of the XNAT imaging informatics platform that’s designed to close the gap between artificial intelligence (AI) model development and clinical deployment. Read More...

01/21/2026 - This is the first class of the Statistical Analysis of Research Data (SARD) series offered by NCI Center for Cancer Training. The focus for this session is univariate data analysis and participants will learn Read More...

01/15/2026 - The “NIH Data Science Trainers Group” invites you to join us. We meet monthly (3 rd Thursday, 3-4 PM) on topics of interest within the bioinformatics and data science training community. Read More...

01/15/2026 - Gil Kanfer, PhD, of the NCI CCR High-Throughput Imaging Facility (HiTIF), in the Laboratory of Receptor Biology and Gene Expression (LRBGE) , will present the spatial biology analysis stack HiTIF is building to support Center Read More...

12/16/2025 - Abstract: Spatial transcriptomics (ST) is evolving rapidly as a pivotal technology in studying the biology of tumors and their associated tumor microenvironments (TME). However, where/how it can impact research remain unclear. In this Read More...

11/06/2025 - Qlucore Omics Explorer is a point-and-click software that enables analysis of RNA sequencing (bulk and single cell), proteomics and metabolomics data. It’s machine learning capabilities allow for cell type classification. This Read More...

10/30/2025 - Qiagen Ingenuity Pathway Analysis (IPA) is a point-and-click software that enables scientists to discern how genomic, transcriptomic, proteomic, and metabolomic changes influence molecular biology pathways and networks. This software is available to NCI investigators. Read More...

10/29/2025 - The Buenrostro lab is broadly dedicated to advancing our knowledge of gene regulation and the downstream consequences on cell fate decisions. To do this, the Buenrostro lab develops new technologies utilizing molecular biology, microscopy Read More...

10/23/2025 - Qiagen CLC Genomics Workbench is a point-and-click software that runs on a personal computer and enables bulk RNA sequencing, ChIP sequencing, long reads, and variant analysis that is available to NCI scientists. Submit a Read More...

09/23/2025 - There are many challenges associated with moving cancer AI originally developed in a research setting into a clinical setting, including into clinical trials. During this event, participants will discuss the integration of AI in Read More...

07/09/2025 - From image analy i to federated learning and multimodal modeling, generative AI can be u ed to tudy ob ervational ucce ion acro cale and data type . At DCEG' Data cience and Engineering Re Read More...

07/08/2025 - Thi pre entation de cribe the ba ic mechanic of con tructing a deci ion tree and interpreting the re ult . Deci ion tree will be u ed to determine factor a ociated with 2 Read More...

05/19/2025 - Immunotherapy has the potential to revolutionize the way we treat cancer, but a key challenge has been finding ways to tailor that therapy to the right patient at the right time. Attend this webinar, Read More...

05/14/2025 - Please note: Registration is required to get the Meeting Link for this event. Please pre-register. The Human Tumor Atlas Network (HTAN) is a National Cancer Institute (NCI)-funded initiative to construct 3-dimensional atlases of Read More...

04/23/2025 - Dr. Ruppin's research is focused on multi-disciplinary, algorithmic, computationally driven analysis of large-scale biomedical omics and clinical data, with an emphasis on AI and machine / deep learning approaches. Overall, it centers on three Read More...

Our Team Tatiana S. Karpova Ph.D.Core Headkarpovat@nih.govBuilding 41, Room C615240-760-6637 David A. Ball Ph.D.Core Biologistballa@nih.govBuilding 41, Room B114D240-760-6577 Mohamadreza Fazel, Ph.D.Core Biologistmohamadreza. Read More...

2016-2024 Publications using images obtained in OMC

04/16/2026 - The ability to measure gene expression levels for individual cells (vs. pools of cells) and with spatial resolution is crucial to address many important biological and medical questions, such as the study of stem Read More...

07/23/2025 - The QIIME platform, including QIIME 1 and QIIME 2, has been extensively applied in microbiome research, repeatedly making analyses that were once challenging or impossible into routine tasks. While QIIME began as a marker gene (e. Read More...

06/26/2025 - Join u for a webinar introducing MIRA, a Python oftware package de igned for the analy i of ingle-cell RNA- eq, ATAC- eq, and multimodal data. Di cover how MIRA help decode the ci Read More...

06/13/2025 - Dr. Fuhai Li,&nb p;A ociate Profe or at the chool of Medicine and Computer cience & Engineering, Wa hington Univer ity, will pre ent novel approache that combine large language Read More...

This archive contains past and present issues of the  BTEP BioInformatics Bulletin. The BTEP Bioinformatics Bulletin features select upcoming bioinformatics events offered across NIH and is distributed monthly via email to the Center Read More...

  Update: Please contact your IC representative to get access to the Anaconda Business license as it has transitioned from enterprise to seat-based licensing. For questions, email anaconda@nih.gov. Anaconda ( https://www.anaconda. Read More...